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Genes Behind Impulsive Behaviour Linked to Mental Health, Obesity and Chronic Disease, Study Finds

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Genes associated with impulsive decision-making may also increase the risk of mental health disorders, obesity and several chronic conditions, according to a major new study that examines how deeply impulsivity is rooted in human biology.

The research, published in Molecular Psychiatry, suggests that tendencies such as seeking quick rewards are not only inherited but tied to a broad set of physical and psychological health outcomes over a person’s lifetime. The findings come from one of the largest genetic analyses of impulsivity to date.

“Impulsive decision-making is something we all experience, but its biological roots have been surprisingly difficult to pin down,” said Sandra Sanchez-Roige, an associate professor of psychiatry at the University of California San Diego and one of the study’s authors.

The team analysed genome-wide data from nearly 135,000 individuals who participated in 23andMe’s genetic testing programme. They focused on a behaviour known as delay discounting — the preference for smaller, immediate rewards over larger, future ones. Scientists have long linked this trait to impulsivity, but the scale of the dataset allowed researchers to identify 73 psychiatric, cognitive and physical health traits connected to it.

Those traits include indicators of substance use, depression, executive function, chronic pain, cardiovascular health, obesity, immune system complications and insomnia. The study reports that the connections involve “both overlapping and trait-specific biological processes,” with several genes linked to dopamine activity, brain structure and metabolic pathways that shape neural development.

To assess how these genetic patterns translate into long-term health impacts, the researchers built genetic risk scores for impulsive behaviour and studied medical records from more than 66,000 people. They found associations with 212 medical conditions, including type 2 diabetes, chronic pain and heart disease.

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Sanchez-Roige said the results show that delay discounting is “measurable, highly heritable and relevant to many aspects of health,” spanning brain development, cognition and physical wellbeing.

The study raises new questions about the degree to which the identified genes directly contribute to health conditions or whether their influence is shaped by environmental factors. The authors said future research should examine whether addressing social or educational factors linked to impulsivity could reduce associated health risks.

“By continuing to investigate this fundamental decision-making process, we may uncover new ways to prevent or treat a wide range of conditions,” Sanchez-Roige said.

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One-Week Social Media Break Linked to Lower Depression and Anxiety in Young Adults, Study Finds

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A week-long break from social media may help ease depression, anxiety and insomnia among young adults, according to new research that adds to growing concerns about the mental health impact of excessive screen time.

The study, published in JAMA Network Open, tracked 373 participants aged between 18 and 24 as they spent two weeks actively using Facebook, Instagram, Snapchat, TikTok and X. Researchers monitored their usage patterns, then asked them to report their mental wellbeing before, during and after the test period.

After the two-week monitoring phase, almost 80 per cent of participants agreed to take a voluntary one-week detox from social media. Among those who did so, one in four reported reduced symptoms of depression. Sixteen per cent said their anxiety symptoms had eased, while 15 per cent noted improvements in insomnia. The detox appeared most beneficial for those who entered the study with moderate or high levels of depression, anxiety or sleep difficulties.

The researchers noted that the break did not reduce loneliness, a finding they attributed to the sudden loss of regular interactions, such as comments, messages and likes, that young people typically receive on these platforms.

Josep Maria Suelves, a researcher at the Open University of Catalonia, said the findings highlight a wider issue. While social media can support communication and community, he said “frequent and prolonged use of these tools can interfere with healthy behaviours,” including sleep, exercise and meaningful social contact. This, he noted, raises risks linked to sedentary habits, insufficient rest and exposure to negative social pressures that can worsen depression or addiction.

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Although participants were asked to restrict their screen time, they did not eliminate it completely. They still spent around 30 minutes per day on their phones during the detox, compared to nearly two hours beforehand. Instagram and Snapchat were the platforms most likely to draw users back during the break, while Facebook, TikTok and X saw fewer logins.

The authors said the results are promising but stressed the need for broader studies to identify how long a social media detox should last to deliver consistent mental health benefits. They also said the study’s demographics — mostly women, university students and highly educated participants — limit how widely the findings can be applied.

José Perales, a psychology professor at the University of Granada, said the voluntary nature of the detox phase was another limitation. Allowing participants to choose whether or not to take a break could skew results, he said, since those who opted in may have been more motivated or more aware of their symptoms.

Perales cautioned that the study’s relevance is “very modest” and may join “the long list of inconclusive and easily overinterpreted studies” in the debate over social media’s impact on young people’s wellbeing.

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Health Experts Warn of Rising Cannabis Addiction as Stronger Strains Drive Higher Risks

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As concerns grow about the increasing strength and availability of cannabis across Europe and the United States, health specialists are urging the public to recognise the early signs of addiction. The warning comes amid rising cases of cannabis use disorder, a condition now affecting a significant share of users.

“If pot interferes with your daily life, health, or relationships, those are red flags,” said Dr Smita Das, an addiction psychiatrist at Stanford University. She noted that a persistent myth continues to mislead users: the belief that marijuana is not addictive. According to her, this misconception has spread even as evidence shows a steady rise in dependency.

Cannabis is now the most widely used illegal drug in Europe, according to the European Union Drugs Agency (EUDA). Data from the US Centers for Disease Control and Prevention indicates that about three in ten users develop cannabis use disorder. Dr Das stresses that addiction is a documented medical condition. “Cannabis is definitely something that someone can develop an addiction to,” she said.

A major factor behind the rise is the growing potency of modern cannabis products. In the 1960s, most marijuana contained under 5 per cent THC, the psychoactive component. EUDA figures show that today’s cannabis flowers contain an average of 11 per cent THC, while concentrates reach about 23 per cent. Experts say stronger products increase the likelihood of dependency, especially among frequent users.

Cannabis use disorder is diagnosed using criteria from the Diagnostic and Statistical Manual of Mental Disorders. These criteria include needing larger amounts of the drug to achieve the same effect, experiencing withdrawal symptoms, and spending excessive time using or seeking cannabis. “When we break it down into these criteria that have to do with the impacts of their use, it’s a lot more relatable,” Dr Das said.

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The severity of the condition varies. Meeting two criteria in the past year signals a mild form, while six or more indicate a severe case. International data shows that around 0.5 per cent of EU residents aged 15 to 64 had the disorder in 2019. Experts emphasise that addiction affects individuals differently. The same amount of cannabis may disrupt one person’s daily life significantly while leaving another largely unaffected.

Treatment options are available. Motivational interviewing, a goal-oriented counselling method, and cognitive behavioural therapy (CBT) are among the most effective approaches. Peer support groups, including Marijuana Anonymous, also play an important role.

Online communities are expanding as well. Dave Bushnell, a retired digital executive creative director, founded a Reddit group 14 years ago for people grappling with cannabis dependency. The forum now counts 350,000 members. “This is potheads taking care of potheads,” he said, describing the value of peer support.

Doctors encourage anyone struggling with marijuana use to seek help early. As Dr Das noted, “Just because something’s legal doesn’t mean that it’s safe.”

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New Global Reviews Confirm HPV Vaccine Strongly Reduces Cervical Cancer Risk With No Serious Side Effects

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Studies show girls vaccinated by age 16 face dramatically lower cervical cancer risk with no major side effects. Two major international reviews have reaffirmed that the human papillomavirus (HPV) vaccine is highly effective in preventing cervical cancer, offering one of the clearest assessments to date of its long-term benefits and safety. The impact of the slowdown in major global economies will be “smaller” on the UAE’s growth and exports due to its relatively less exposure to those markets compared to other markets across the region, the World Bank said.

The Cochrane reviews, released this week, analysed data from clinical trials and real-world research involving more than 132 million people worldwide. The findings show that girls aged 16 or younger who received the HPV vaccine were 80 per cent less likely to develop cervical cancer compared to unvaccinated peers. The jab also significantly reduced precancerous cervical changes, with the strongest protection observed when individuals received the vaccine before any exposure to the virus.

“We now have clear and consistent evidence from around the world that HPV vaccination prevents cervical cancer,” said Nicholas Henschke, one of the review authors and head of Cochrane Response.

HPV is a widespread family of viruses, most of which are harmless, but several strains are known to cause cancers of the cervix, anus, penis, vulva, vagina, mouth and throat. According to the World Health Organization, cervical cancer remains one of the most common cancers in women, with about 660,000 new cases and an estimated 350,000 deaths recorded globally in 2022.

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While vaccines such as Cervarix and Gardasil have long been recognised as major medical advances, they have also been at the centre of controversy. In recent years, Merck & Co., the manufacturer of Gardasil, has faced lawsuits alleging health complications linked to the vaccine. A US judge dismissed the claims earlier this year, calling them speculative and unsupported by evidence.

Cochrane’s review assessed both minor and serious side effects reported in vaccine recipients. The researchers found that common reactions—such as temporary soreness in the arm—were mild and short-lived. After comparing safety reports with real-world follow-up data, the team found no evidence that HPV vaccination increases the risk of severe medical problems. Serious health issues were recorded at similar rates in both vaccinated and unvaccinated groups.

“An important finding was that the commonly reported side effects of the vaccine, often discussed on social media, were found to hold no evidence of a real link to vaccination,” Henschke said.

The results support ongoing global guidance to vaccinate both girls and boys ideally before they turn 16, when protection is strongest. Dr Jo Morrison, a gynaecological oncologist and co-author of the review, said vaccinating boys helps strengthen community-wide protection and is expected to reduce cancers affecting men later in life.

While most existing studies come from high-income countries, researchers say more data from lower-income regions is needed, especially in areas with the highest cervical cancer rates. Scientists expect clearer evidence in the years ahead as long-term monitoring continues.

“It will take decades to fully understand the impact of vaccination,” Morrison added, noting that the early findings already point to a significant reduction in future cancer cases.

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