Health
Fake Records, Vaccine Gaps and Mismanagement Hamper Global Polio Eradication Push
Despite decades of effort and billions in funding, polio continues to defy eradication in parts of Afghanistan and Pakistan — the last two countries where the disease remains endemic. A recent investigation has revealed that deep-seated issues, including falsified immunisation data, reliance on an imperfect oral vaccine, and strategic missteps, have allowed the virus to persist.
The findings, published by the Associated Press, draw on internal documents and interviews with health workers and former World Health Organization (WHO) staff. They paint a troubling picture of systemic flaws within the Global Polio Eradication Initiative, one of the most ambitious public health campaigns in history.
While the campaign has vaccinated more than 3 billion children and prevented an estimated 20 million paralysis cases worldwide, its failures in South Asia raise concerns. In both Afghanistan and Pakistan, internal WHO reports dating back to 2017 document repeated warnings about vaccine mishandling, falsified records, and untrained staff. One report from Kandahar, for example, described vaccinators working “in a hurried manner” with “no plan for monitoring” and entire villages being skipped for years.
In Pakistan, front-line workers like Sughra Ayaz say logistical challenges and community resistance are rampant. “In many places, our work is not done with honesty,” Ayaz told AP, noting that some supervisors instruct workers to falsely mark children as vaccinated to meet targets. Families in poor regions often demand basic necessities over immunisations, while others cling to conspiracy theories about vaccine-induced sterilisation.
At the heart of the controversy is the oral polio vaccine (OPV), a cornerstone of the global campaign. While inexpensive and easy to administer, the OPV contains live, weakened virus strains. In rare cases, these can mutate and cause vaccine-derived outbreaks, particularly in communities with low vaccination coverage. Since 2021, several hundred such cases have been recorded annually, with 98 already reported this year.
Public health experts widely agree that a switch to the injectable inactivated polio vaccine (IPV) is essential. Unlike the oral version, IPV carries no risk of mutation. However, it is more expensive and requires trained healthcare workers — a major hurdle in remote and unstable areas.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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