Health
Top Medical Breakthroughs of 2025 Offer Hope for Patients Worldwide
This year has seen a series of major medical advancements that could transform health care for millions around the globe. Euronews Health reviewed leading medical journals to highlight some of the most promising developments, from gene editing to organ transplantation and novel vaccine technologies.
In February, scientists performed the world’s first personalised CRISPR gene-editing therapy on a baby with a rare and often fatal genetic disorder. The procedure involved directly editing faulty genes in the infant’s liver. While the child will require lifelong monitoring, the treatment has significantly reduced his dependence on medications and improved his quality of life. By November, the baby’s mother reported that he had begun walking and reaching other developmental milestones. Researchers hailed the procedure as a major breakthrough, suggesting that CRISPR could benefit other patients with genetic disorders in the future.
Messenger RNA, or mRNA, vaccines also continued to make headlines in 2025. Building on the success of COVID-19 vaccines, researchers tested mRNA technology against influenza, HIV, genetic diseases, and cancer. Early trials showed that HIV vaccines using mRNA could stimulate neutralising antibodies, which help the immune system defend cells against viral infection. While larger trials are needed, scientists say these developments demonstrate the broad potential of mRNA technology to tackle multiple diseases.
In the field of organ transplantation, xenotransplantation — the transfer of organs between species — achieved notable progress. In a milestone procedure, a genetically modified pig liver was transplanted into a 71-year-old man who could not receive a human liver due to liver disease and cancer. The patient survived for 171 days, showing that pig organs can perform critical functions in humans. Scientists believe that such transplants may one day reduce the shortage of donor organs, complementing ongoing experiments with pig kidneys, lungs, and hearts.
A breakthrough in dementia research also emerged in the United Kingdom, where scientists used living human brain tissue to study Alzheimer’s disease in real time. By exposing healthy brain cells to amyloid beta, a toxic protein linked to the disease, researchers observed how cell connections deteriorate at early stages. This approach could accelerate the development of treatments for dementia, which currently has no cure.
Finally, weight loss drugs used to treat obesity and diabetes showed potential benefits for other conditions, including addiction and certain psychotic disorders. Studies suggest these drugs may improve blood flow, reduce inflammation, and affect the brain’s reward system. However, pharmaceutical companies caution that they are not universal solutions. In November, Novo Nordisk reported that semaglutide, the active ingredient in Ozempic and Wegovy, had no effect on cognition in patients with dementia or mild cognitive impairment.
These five medical advances highlight the rapid pace of scientific progress in 2025, offering hope for patients and families facing a range of serious health challenges.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
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