Health
Chinese Study Links Gut Bacterium to Higher Risk of Preterm Birth
A new study from China has identified a possible link between gut health and preterm birth, suggesting that the presence of a common bacterium in pregnant women could increase the risk of early delivery.
The research, published this week in the journal Cell Host & Microbe, focused on Clostridium innocuum (C. innocuum), a gut bacterium found to produce an enzyme capable of breaking down estradiol, a hormone essential for maintaining pregnancy. Women carrying the bacterium in their gut microbiome were found to face a higher likelihood of giving birth before 37 weeks of pregnancy.
“Preterm birth is a leading cause of death in newborns and children under five,” said An Pan, an epidemiology professor at Huazhong University of Science and Technology and one of the study’s authors. “This study suggests that for pregnant women or those preparing to conceive, monitoring the gut microbiome may help prevent potential adverse outcomes.”
Preterm birth and its risks
According to the World Health Organization (WHO), preterm birth remains a major global health issue, accounting for around 900,000 deaths in children under five in 2019 alone. Babies born before 37 weeks often face breathing difficulties, developmental delays, and higher risks of long-term disabilities, particularly if born before 32 weeks.
While known risk factors include infections, diabetes, multiple pregnancies, and genetic influences, many preterm births have no clear cause. The Chinese study suggests that gut bacteria may represent a previously overlooked factor.
How the study was conducted
Researchers analyzed data from two large cohorts of more than 5,000 women in early and mid-pregnancy across China. Stool and blood samples were collected to study microbial composition, genetic variation, and hormone metabolism.
The team identified 11 microbial groups linked to preterm birth, with C. innocuum showing the strongest association. Laboratory analysis revealed that the bacterium produces an enzyme that depletes estradiol levels, potentially disrupting pathways critical to sustaining pregnancy.
“Estradiol regulates processes that support pregnancy and trigger childbirth,” explained Zelei Miao, a co-author from Westlake University. “We propose that dysregulated estradiol levels caused by C. innocuum could explain the link between the gut microbiome and preterm birth.”
Broader implications and caveats
The findings could pave the way for new approaches to monitoring pregnancy health, potentially using microbiome testing to flag higher-risk cases. However, researchers cautioned that their study was limited to Chinese cohorts, where preterm birth rates are relatively low. Since the gut microbiome is influenced by diet, environment, and genetics, further studies are needed in more diverse populations to confirm the results.
Despite these limitations, experts say the research highlights the gut microbiome as a potentially modifiable factor in reducing preterm births worldwide—a condition that remains one of the most pressing challenges in maternal and child health.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
AI Models Show Ability to Mimic Human Emotions, Offering New Pathways for Mental Health Research
Health
AI Saves Clinicians Weeks of Work but Health Systems Struggle to Keep Up, Philips Report Finds
-
Entertainment2 years agoMeta Acquires Tilda Swinton VR Doc ‘Impulse: Playing With Reality’
-
Sports2 years agoChina’s Historic Olympic Victory Sparks National Pride Amid Controversy
-
Business2 years agoSaudi Arabia’s Model for Sustainable Aviation Practices
-
Business2 years agoRecent Developments in Small Business Taxes
-
Home Improvement2 years agoEffective Drain Cleaning: A Key to a Healthy Plumbing System
-
Politics2 years agoWho was Ebrahim Raisi and his status in Iranian Politics?
-
Sports2 years agoKeely Hodgkinson Wins Britain’s First Athletics Gold at Paris Olympics in 800m
-
Business2 years agoCarrectly: Revolutionizing Car Care in Chicago
