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Common Antibiotic May Reduce Schizophrenia Risk in Teenagers, Study Suggests

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A widely used antibiotic could play a surprising role in lowering the risk of schizophrenia among young people, according to new research published in the American Journal of Psychiatry.

The study found that teenagers who were prescribed doxycycline, a common antibiotic used to treat infections and acne, were 30 to 35 percent less likely to develop schizophrenia in adulthood than those treated with other antibiotics. Researchers described the findings as “tentative but exciting,” emphasising that while the results are promising, more research is needed to confirm them.

Schizophrenia affects around 23 million people globally and typically develops in early adulthood. The condition is characterised by hallucinations, delusional thinking, and cognitive difficulties, which can significantly disrupt daily life. While medication and therapy can help manage symptoms, there is currently no cure.

The Finnish study examined health records from more than 56,000 adolescents who had received mental health treatment. Of these, about 16,000 were prescribed doxycycline. The results showed a notable difference in schizophrenia diagnoses later in life, suggesting that the antibiotic might offer some level of protection.

Although the study was observational and cannot prove that doxycycline directly prevents schizophrenia, researchers believe the link may be tied to how the drug reduces inflammation in the brain. Doxycycline is known to have anti-inflammatory properties, and inflammation has been increasingly linked to psychiatric disorders.

The team also pointed to another possible mechanism: synaptic pruning. This is a natural process in which the brain eliminates unnecessary neurons and synapses during adolescence. When pruning occurs abnormally, it has been associated with schizophrenia. The researchers suggest doxycycline may influence this process in a beneficial way.

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“This is an important signal to further investigate the protective effect of doxycycline and other anti-inflammatory treatments in adolescent psychiatry patients,” said Ian Kelleher, the study’s lead author and a professor of child and adolescent psychiatry at the University of Edinburgh. He added that the approach “could potentially reduce the risk of developing severe mental illness in adulthood.”

However, experts not involved in the study urged caution. Dominic Oliver, a psychiatry researcher at the University of Oxford, noted that “many other treatments have shown early promise and have ultimately shown not to be effective in large-scale trials.”

Dr Katharina Schmack, a psychosis researcher at The Francis Crick Institute in London, said that while the findings were statistically significant, “the absolute numbers are modest.” She explained that after doxycycline treatment, instead of five out of 100 people developing schizophrenia, the figure would drop to about two or three.

Both experts agreed that the research opens a valuable avenue for further investigation into how inflammation and brain development affect schizophrenia risk. As Schmack put it, “Uncovering clinical associations in studies like this is important because this can direct further biological investigations.”

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Study Finds AI Systems Can Repeat Fake Medical Claims When Framed Credibly

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“Large language models accept fake medical claims if presented as realistic in medical notes and social media discussions, a study has found.”

As more people turn to the internet to research symptoms, compare treatments and share personal health experiences, artificial intelligence tools are increasingly being used to answer medical questions. A new study warns that many of these systems remain vulnerable to medical misinformation, particularly when false claims are presented in authoritative or realistic language.

The findings, published in The Lancet Digital Health, show that leading artificial intelligence systems can mistakenly repeat incorrect medical information when it appears in formats that resemble professional healthcare documents or trusted online discussions. Researchers analysed how large language models respond when faced with false medical statements written in a credible tone.

The study examined responses from 20 widely used language models, including systems developed by OpenAI, Meta, Google, Microsoft, Alibaba and Mistral AI, as well as several models specifically fine-tuned for medical use. In total, researchers assessed more than one million prompts designed to test whether AI would accept or reject fabricated health information.

Fake statements were inserted into real hospital discharge notes, drawn from common health myths shared on Reddit, or embedded in simulated clinical scenarios written to resemble authentic healthcare guidance. Across all models tested, incorrect information was accepted around 32 percent of the time. Performance varied significantly, with smaller or less advanced models accepting false claims in more than 60 percent of cases, while more advanced systems, including ChatGPT-4o, did so in roughly 10 percent of responses.

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The researchers also found that medical fine-tuned models performed worse than general-purpose systems, raising concerns about tools designed specifically for healthcare use.

“Our findings show that current AI systems can treat confident medical language as true by default, even when it’s clearly wrong,” said Eyal Klang of the Icahn School of Medicine at Mount Sinai, one of the study’s senior authors. He added that how a claim is written often matters more to the model than whether it is accurate.

Some of the accepted misinformation could pose real risks to patients. Several models endorsed claims such as Tylenol causing autism during pregnancy, rectal garlic boosting immunity, mammograms causing cancer, and tomatoes thinning blood as effectively as prescription medication. In another case, a discharge note incorrectly advised patients with oesophageal bleeding to drink cold milk, which some models repeated without flagging safety concerns.

The study also tested how AI systems responded to flawed arguments known as fallacies. While many fallacies prompted scepticism, models were more likely to accept false claims framed as expert opinions or warnings of catastrophic outcomes.

Researchers say future work should focus on measuring how often AI systems pass on falsehoods before they are used in clinical settings. Mahmud Omar, the study’s first author, said the dataset could help developers and hospitals stress-test AI tools and track improvements over time.

The authors said stronger safeguards will be essential as AI becomes more deeply embedded in healthcare decision-making.

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Moderate Caffeine Intake Linked to Lower Dementia Risk, Study Finds

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“Moderate daily consumption of caffeine is associated with a lower risk of dementia and slower cognitive decline, according to a new study.”

Drinking coffee or tea on a regular basis may help support healthy brain ageing, researchers reported, adding to growing evidence that lifestyle and dietary factors can influence cognitive health later in life. The findings suggest that moderate caffeine intake could play a modest role in reducing the risk of dementia and preserving cognitive function over time.

The study, published in JAMA, found that consuming two to three cups of caffeinated coffee or one to two cups of tea per day was associated with up to an 18% lower risk of developing dementia. The strongest benefits were seen among participants with moderate caffeine intake, though higher levels of consumption did not appear to cause harm and showed similar protective effects.

“When searching for possible dementia prevention tools, we thought something as prevalent as coffee may be a promising dietary intervention,” said senior author Daniel Wang, an associate scientist at the Mass General Brigham Department of Medicine and an assistant professor at Harvard Medical School.

Researchers analysed data from more than 130,000 participants who underwent repeated dietary, cognitive and dementia assessments. The participants were followed for as long as 43 years, allowing the team to assess long-term patterns of coffee and tea consumption and their potential impact on cognitive health. During the follow-up period, 11,033 participants developed dementia.

The analysis showed that both men and women with the highest caffeine intake had an 18% lower risk of dementia compared with those who consumed little or no caffeine. Coffee drinkers also reported fewer symptoms of subjective cognitive decline, defined as self-perceived memory loss or confusion, with rates of 7.8% compared with 9.5% among those who drank less coffee.

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Scientists believe that coffee and tea may offer neuroprotective benefits due to bioactive compounds such as caffeine and polyphenols. These substances are thought to reduce inflammation and cellular damage, while supporting blood vessel health in the brain. Previous studies have also linked caffeine consumption to improved insulin sensitivity and better vascular function, both of which are associated with cognitive health.

The authors cautioned that the research was observational and cannot prove a direct cause-and-effect relationship. The study also did not differentiate between types of coffee or tea, or account for variations in preparation methods, including roast levels, origins or brewing techniques.

The researchers noted that early prevention remains crucial, as current dementia treatments provide limited benefit once symptoms develop. Dementia typically progresses from subjective cognitive decline to mild cognitive impairment before advancing to clinical dementia.

While the findings are encouraging, the authors stressed that caffeine consumption is only one of several factors that may help protect cognitive function with age. “Our study suggests that caffeinated coffee or tea consumption can be one piece of that puzzle,” Wang said.

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Growing Research Links Tattoos to Possible Cancer Risks, Experts Say

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Tattoos are more popular than ever, but a growing body of research suggests a connection between permanent ink and certain types of cancer. How concerned should the public be?

From tribal sleeves to lower-back butterflies, humans have been inking their skin for thousands of years. For most, the main concern has been the fear of future regrets. However, recent studies suggest that tattoos could carry more serious long-term health risks.

The popularity of tattoos has risen sharply in recent years. Research published in the European Journal of Public Health estimates that between 13 and 21 percent of people in Western Europe now have at least one tattoo. Despite this prevalence, relatively little is known about the potential long-term effects of permanent ink.

Previous studies have shown that tattoo pigments can accumulate in the lymph nodes, sometimes causing inflammation and, in rare cases, lymphoma—a type of blood cancer. A 2025 study by the University of Southern Denmark (SDU) expanded on this, reporting that individuals with tattoos may face higher risks of skin cancer and lymphoma. Using a cohort of randomly selected twins, the researchers found that tattooed participants had nearly four times the risk of skin cancer compared with their non-tattooed siblings.

The study also suggested that tattoo size could affect risk, with designs larger than the palm associated with higher hazard rates.

“We have evidence that there is an association [between the amount of ink and risk] for lymphoma and for skin cancer,” said Signe Bedsted Clemmensen, co-author of the study and assistant professor of biostatistics at SDU. “For lymphoma, the hazard rate is 2.7 times higher, so this is quite a lot. And for skin cancers, before it was 1.6 and now it’s 2.4. This indicates that the more ink you have, the higher the risk, the higher the hazard rate.”

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Clemmensen emphasized that these findings remain preliminary, with many variables—including ink types, tattoo placement, and genetic and environmental factors—still under investigation. “The bottom line is, more research is needed,” she said. “But also, the next step I think is studying the biological mechanisms [of getting tattooed] and trying to understand what happens there.”

Experts also note other risks unrelated to cancer. Tattoo inks consist of pigments combined with a carrier fluid to deposit color into the dermis. Some inks, often imported, can contain trace amounts of heavy metals such as nickel, chromium, cobalt, and lead, which can trigger allergic reactions or immune sensitivity. In 2022, the European Union restricted more than 4,000 hazardous substances in tattoo inks under its REACH regulations.

While tattoos are generally considered safe when applied hygienically, the long-term health consequences remain uncertain. “It’s up to each of us how we choose to live our lives, right? But as a researcher, it’s also my job to inform people of these risks,” Clemmensen said. “Or, when it comes to tattooing, right now it’s more about informing people about how little we know.”

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