Health
New Review Finds No Clear Evidence That Ketamine Eases Chronic Pain
A major scientific review has cast doubt on the use of ketamine as a treatment for chronic pain, warning that current evidence is too weak to support its effectiveness.
Once known largely as a party drug, ketamine has in recent years been repurposed in wellness and medical circles, with clinics across Europe offering it as a potential remedy for depression and long-lasting pain. The anaesthetic has a long history in hospitals, where it is used to sedate patients during surgery and as an emergency painkiller. But despite the growing interest, researchers say its benefits for chronic conditions remain unproven.
The review, conducted by Cochrane, an independent nonprofit research organisation, analysed data from 67 clinical trials involving more than 2,300 participants. The trials tested five drugs that target the N-methyl-D-aspartate (NMDA) receptor, which influences how pain signals are processed in the brain. Alongside ketamine, the review included memantine, dextromethorphan, amantadine, and magnesium.
According to the findings, none of the drugs showed clear or consistent benefits for treating chronic pain conditions such as diabetic nerve pain, fibromyalgia, post-shingles pain, or complex regional pain syndrome.
“We want to be clear – we’re not saying ketamine is ineffective, but there’s a lot of uncertainty,” said Michael Ferraro, one of the study’s authors and a researcher at the University of New South Wales. “The data could point to a benefit or no effect at all. Right now, we just don’t know.”
The analysis also highlighted the risks of ketamine, especially when administered intravenously. Reported side effects included delusions, paranoia, delirium, nausea, and vomiting, which were described as “distressing for many patients.”
Importantly, the review did not examine ketamine’s role in treating depression or its potential as a replacement for opioid painkillers. Researchers warned, however, against extending ketamine’s established short-term use in emergency settings to long-term management of chronic conditions.
“We’ve seen the harm that can come from taking medicines developed for acute pain and applying them to chronic pain – opioids are a prime example,” said James McAuley, a professor at UNSW and co-author of the study. “Now we’re seeing a similar pattern with ketamine. We need to be careful not to rush into widespread use without strong evidence.”
The findings arrive amid a surge of interest in new pain treatments, as doctors and patients seek alternatives to opioids. But for now, the researchers conclude, there is little reliable data to support ketamine as a solution for chronic pain – and more rigorous studies are urgently needed.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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