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UK Study Finds Common Chemicals May Harm Gut Bacteria and Human Health

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Dozens of widely used chemicals could be toxic to gut bacteria, potentially affecting human health, according to a new study by UK scientists. Researchers tested more than 1,000 chemicals in the laboratory and identified 168 that appeared to prevent healthy gut bacteria from growing, raising concerns about their impact on the gut microbiome.

The gut microbiome consists of thousands of bacterial species and other microorganisms that live in the digestive tract. Scientists have linked it to numerous health outcomes, including cancer, heart disease, type 2 diabetes, insomnia, and complications during pregnancy such as preterm birth.

In the study, researchers tested 1,076 chemical contaminants—including pesticides, herbicides, industrial chemicals, and so-called “forever chemicals” like per- and polyfluoroalkyl substances (PFAS)—on 22 species of gut bacteria. Many of the harmful chemicals, including flame retardants and plasticisers used in everyday products, were not previously known to affect living organisms, the team said.

“We were surprised that some of these chemicals had such strong effects,” said Indra Roux, a researcher at the University of Cambridge and one of the study’s authors. “Many industrial chemicals that we are regularly in contact with weren’t thought to affect living organisms at all, but they do.”

The chemicals can enter the human body through food, water, and other environmental exposures. While the precise level of real-world exposure remains unclear, the researchers noted that environmental pollutants have been linked to changes in the gut microbiome that may contribute to obesity and insulin resistance.

Laboratory tests also revealed that some bacteria altered their functions to survive chemical exposure, which in some cases led to increased resistance to antibiotics. If similar effects occur in humans, this could make infections harder to treat and worsen the growing public health problem of antimicrobial resistance (AMR).

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Traditionally, chemical safety assessments focus on the chemicals’ intended targets—such as how effectively a pesticide kills pests—without considering their potential impact on the human gut. “Safety assessments of new chemicals for human use must ensure they are also safe for our gut bacteria, which could be exposed to the chemicals through our food and water,” said Stephan Kamrad, another author from the University of Cambridge.

The study, published in Nature Microbiology, calls for more real-world data to determine whether laboratory findings translate to effects on human gut health. Meanwhile, researchers advise people to reduce exposure where possible, for example by washing fruits and vegetables thoroughly and avoiding the use of pesticides at home.

The findings add to growing evidence that everyday chemical exposures may have unintended consequences on human health, highlighting the need for more comprehensive safety testing that considers the gut microbiome.

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One-Week Social Media Break Linked to Lower Depression and Anxiety in Young Adults, Study Finds

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A week-long break from social media may help ease depression, anxiety and insomnia among young adults, according to new research that adds to growing concerns about the mental health impact of excessive screen time.

The study, published in JAMA Network Open, tracked 373 participants aged between 18 and 24 as they spent two weeks actively using Facebook, Instagram, Snapchat, TikTok and X. Researchers monitored their usage patterns, then asked them to report their mental wellbeing before, during and after the test period.

After the two-week monitoring phase, almost 80 per cent of participants agreed to take a voluntary one-week detox from social media. Among those who did so, one in four reported reduced symptoms of depression. Sixteen per cent said their anxiety symptoms had eased, while 15 per cent noted improvements in insomnia. The detox appeared most beneficial for those who entered the study with moderate or high levels of depression, anxiety or sleep difficulties.

The researchers noted that the break did not reduce loneliness, a finding they attributed to the sudden loss of regular interactions, such as comments, messages and likes, that young people typically receive on these platforms.

Josep Maria Suelves, a researcher at the Open University of Catalonia, said the findings highlight a wider issue. While social media can support communication and community, he said “frequent and prolonged use of these tools can interfere with healthy behaviours,” including sleep, exercise and meaningful social contact. This, he noted, raises risks linked to sedentary habits, insufficient rest and exposure to negative social pressures that can worsen depression or addiction.

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Although participants were asked to restrict their screen time, they did not eliminate it completely. They still spent around 30 minutes per day on their phones during the detox, compared to nearly two hours beforehand. Instagram and Snapchat were the platforms most likely to draw users back during the break, while Facebook, TikTok and X saw fewer logins.

The authors said the results are promising but stressed the need for broader studies to identify how long a social media detox should last to deliver consistent mental health benefits. They also said the study’s demographics — mostly women, university students and highly educated participants — limit how widely the findings can be applied.

José Perales, a psychology professor at the University of Granada, said the voluntary nature of the detox phase was another limitation. Allowing participants to choose whether or not to take a break could skew results, he said, since those who opted in may have been more motivated or more aware of their symptoms.

Perales cautioned that the study’s relevance is “very modest” and may join “the long list of inconclusive and easily overinterpreted studies” in the debate over social media’s impact on young people’s wellbeing.

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Genes Behind Impulsive Behaviour Linked to Mental Health, Obesity and Chronic Disease, Study Finds

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Genes associated with impulsive decision-making may also increase the risk of mental health disorders, obesity and several chronic conditions, according to a major new study that examines how deeply impulsivity is rooted in human biology.

The research, published in Molecular Psychiatry, suggests that tendencies such as seeking quick rewards are not only inherited but tied to a broad set of physical and psychological health outcomes over a person’s lifetime. The findings come from one of the largest genetic analyses of impulsivity to date.

“Impulsive decision-making is something we all experience, but its biological roots have been surprisingly difficult to pin down,” said Sandra Sanchez-Roige, an associate professor of psychiatry at the University of California San Diego and one of the study’s authors.

The team analysed genome-wide data from nearly 135,000 individuals who participated in 23andMe’s genetic testing programme. They focused on a behaviour known as delay discounting — the preference for smaller, immediate rewards over larger, future ones. Scientists have long linked this trait to impulsivity, but the scale of the dataset allowed researchers to identify 73 psychiatric, cognitive and physical health traits connected to it.

Those traits include indicators of substance use, depression, executive function, chronic pain, cardiovascular health, obesity, immune system complications and insomnia. The study reports that the connections involve “both overlapping and trait-specific biological processes,” with several genes linked to dopamine activity, brain structure and metabolic pathways that shape neural development.

To assess how these genetic patterns translate into long-term health impacts, the researchers built genetic risk scores for impulsive behaviour and studied medical records from more than 66,000 people. They found associations with 212 medical conditions, including type 2 diabetes, chronic pain and heart disease.

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Sanchez-Roige said the results show that delay discounting is “measurable, highly heritable and relevant to many aspects of health,” spanning brain development, cognition and physical wellbeing.

The study raises new questions about the degree to which the identified genes directly contribute to health conditions or whether their influence is shaped by environmental factors. The authors said future research should examine whether addressing social or educational factors linked to impulsivity could reduce associated health risks.

“By continuing to investigate this fundamental decision-making process, we may uncover new ways to prevent or treat a wide range of conditions,” Sanchez-Roige said.

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Health Experts Warn of Rising Cannabis Addiction as Stronger Strains Drive Higher Risks

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As concerns grow about the increasing strength and availability of cannabis across Europe and the United States, health specialists are urging the public to recognise the early signs of addiction. The warning comes amid rising cases of cannabis use disorder, a condition now affecting a significant share of users.

“If pot interferes with your daily life, health, or relationships, those are red flags,” said Dr Smita Das, an addiction psychiatrist at Stanford University. She noted that a persistent myth continues to mislead users: the belief that marijuana is not addictive. According to her, this misconception has spread even as evidence shows a steady rise in dependency.

Cannabis is now the most widely used illegal drug in Europe, according to the European Union Drugs Agency (EUDA). Data from the US Centers for Disease Control and Prevention indicates that about three in ten users develop cannabis use disorder. Dr Das stresses that addiction is a documented medical condition. “Cannabis is definitely something that someone can develop an addiction to,” she said.

A major factor behind the rise is the growing potency of modern cannabis products. In the 1960s, most marijuana contained under 5 per cent THC, the psychoactive component. EUDA figures show that today’s cannabis flowers contain an average of 11 per cent THC, while concentrates reach about 23 per cent. Experts say stronger products increase the likelihood of dependency, especially among frequent users.

Cannabis use disorder is diagnosed using criteria from the Diagnostic and Statistical Manual of Mental Disorders. These criteria include needing larger amounts of the drug to achieve the same effect, experiencing withdrawal symptoms, and spending excessive time using or seeking cannabis. “When we break it down into these criteria that have to do with the impacts of their use, it’s a lot more relatable,” Dr Das said.

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The severity of the condition varies. Meeting two criteria in the past year signals a mild form, while six or more indicate a severe case. International data shows that around 0.5 per cent of EU residents aged 15 to 64 had the disorder in 2019. Experts emphasise that addiction affects individuals differently. The same amount of cannabis may disrupt one person’s daily life significantly while leaving another largely unaffected.

Treatment options are available. Motivational interviewing, a goal-oriented counselling method, and cognitive behavioural therapy (CBT) are among the most effective approaches. Peer support groups, including Marijuana Anonymous, also play an important role.

Online communities are expanding as well. Dave Bushnell, a retired digital executive creative director, founded a Reddit group 14 years ago for people grappling with cannabis dependency. The forum now counts 350,000 members. “This is potheads taking care of potheads,” he said, describing the value of peer support.

Doctors encourage anyone struggling with marijuana use to seek help early. As Dr Das noted, “Just because something’s legal doesn’t mean that it’s safe.”

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