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UK Scientists Celebrate Breakthrough Births Using Three-Person IVF to Prevent Genetic Disorders

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In a significant scientific milestone, eight babies have been born in the United Kingdom using a pioneering fertility technique that combines DNA from three people. The innovation is designed to prevent the transmission of rare, potentially fatal mitochondrial diseases — and represents a major step forward in reproductive medicine.

The births were made possible by a 2016 change in UK law allowing the use of mitochondrial replacement therapy (MRT), a method still banned in countries like the United States but permitted in places such as Australia. Researchers from Newcastle University and Monash University, reporting in the New England Journal of Medicine, said the babies were born following IVF procedures involving 22 women. One additional pregnancy is ongoing.

“This marks an important milestone,” said Dr. Zev Williams, director of the Columbia University Fertility Centre in the U.S. “Expanding the range of reproductive options empowers more couples to pursue safe and healthy pregnancies.”

Mitochondrial disorders are caused by mutations in the small amount of DNA found in the mitochondria — the energy-producing structures in cells inherited only from the mother. These mutations can lead to severe conditions including seizures, muscle weakness, organ failure, and in some cases, death during infancy.

To prevent this, MRT replaces faulty mitochondria with healthy ones from a donor egg. The mother’s nucleus — which contains the vast majority of her genetic material — is transferred into a donor egg that has had its own nucleus removed. The result is an embryo with DNA from three individuals: the mother, the father, and a third donor, though the donor DNA accounts for less than 1% of the child’s total genetic material.

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Experts caution that the procedure is only suitable for women at high risk of passing on mitochondrial diseases, particularly when traditional embryo screening methods are insufficient. One of the eight babies showed slightly elevated levels of abnormal mitochondria, but not enough to pose a health risk, researchers said.

Dr. Andy Greenfield of the University of Oxford called the research “a triumph of scientific innovation,” while stem cell specialist Robin Lovell-Badge emphasized that the small amount of donor DNA is far less than what would be found in procedures like bone marrow transplants.

To date, 35 families in the UK have received approval to use the technique, which is tightly regulated. However, concerns remain over the long-term effects of heritable genetic modifications, a key reason the U.S. has yet to permit clinical research on MRT.

For families affected by mitochondrial disease, the breakthrough brings renewed hope. Liz Curtis, who lost her daughter Lily to a mitochondrial disorder in 2006, called the development “super exciting.” Curtis now leads the Lily Foundation, which supports research into the disease, including the work at Newcastle.

“It’s hope for families that previously had none,” she said.

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Europe Faces Persistent Doctor Shortages Despite Rising Graduate Numbers

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Doctor shortages continue to challenge healthcare systems across Europe, driven by an ageing workforce and a declining interest among graduates in general practice.

Every year, thousands of students complete their medical studies in Europe, yet the region still struggles to meet demand for healthcare professionals. In 2023, over 66,000 doctors graduated in the European Union, equivalent to roughly 15 graduates per 100,000 inhabitants, according to Eurostat. Numbers vary widely between countries, with Türkiye producing 13,720 graduates, Germany 10,186, and Italy 9,795. At the other end of the spectrum, only 31 doctors completed their studies in Montenegro, 52 in Iceland, and 144 in Estonia.

A significant share of graduates in countries such as Bulgaria, Romania, and Latvia are foreign nationals, many of whom leave the country after completing their studies. This has turned some nations into training hubs for doctors while widening regional disparities. Romania, however, has managed to reduce doctor migration over the past decade. According to the World Health Organization (WHO), the number of doctors leaving Romania fell from 1,500 in 2012 to 461 in 2021, thanks to improved pay, training, and working conditions.

“Health worker migration is a reality in our interconnected and globalised world, and we have the solutions to ensure it works for all parties. Countries can learn from each other’s experiences,” said Natasha Azzopardi-Muscat of WHO Europe. She added that failing to manage workforce movement fairly risks worsening health inequities and leaving fragile healthcare systems unable to cope.

Despite more graduates entering the system, shortages remain acute, particularly among general practitioners (GPs). While the overall number of doctors has grown in most countries, only about one in five in the EU work as GPs. Tiago Villanueva, a family physician and president of the European Union of General Practitioners/Family Physicians, told Euronews Health that graduates increasingly choose specialised fields, such as dermatology or ophthalmology, for better work-life balance and quality of life. He added that the solution lies in making general practice more visible and appealing, rather than simply increasing the number of medical graduates.

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Europe’s doctor shortages are unevenly distributed. Austria has the highest ratio of practising doctors at 551 per 100,000 inhabitants, followed by Italy and Cyprus at 535, while Finland has the lowest at 288 per 100,000.

Ageing of the healthcare workforce adds further pressure. In 2023, nearly one-third of doctors in EU countries were over 55, according to OECD data. Countries with large shares of older doctors will need to train sufficient numbers of new professionals while encouraging those nearing retirement to continue working where possible.

With a projected shortage of 950,000 health workers by 2030, Europe faces a critical challenge in balancing rising graduate numbers with the need to retain talent and fill vital roles in general practice and other essential specialties.

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Universal School Meals Could Reduce Global Undernourishment by Nearly a Quarter, Study Finds

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Providing every child with a healthy, sustainable school meal could significantly cut global hunger, prevent diet-related deaths, and reduce the environmental impact of diets, according to new research by University College London (UCL).

Scientists estimate that extending school meal coverage from the current level of about one in five children to all children worldwide by 2030 could reduce the overall prevalence of undernourishment by around 24 percent. The modelling study suggests such an approach could also prevent more than one million deaths each year from diet-related diseases and cut the number of people lacking essential vitamins by roughly 120 million.

“Our modelling shows that healthy and sustainable school meals can generate substantial health and environmental gains in every region of the world,” said Marco Springmann, the corresponding author of the study and modelling lead for the Research Consortium at UCL’s Institute for Global Health. “The evidence is clear: investing in school meals is both effective and economically sound.”

The study compared current school meal coverage with a scenario in which all children receive at least one meal a day. Researchers examined the potential effects on nutrition, long-term health, greenhouse gas emissions, land and water use, and calculated the cost savings from improved health outcomes and reduced environmental damage.

Results show that environmental benefits depend on meal composition. School meals aligned with healthy and sustainable dietary recommendations—emphasizing vegetables and limiting meat and dairy—combined with reduced food waste, could cut food-related environmental impacts by roughly half. The study also examined costs, estimating additional spending equivalent to about 0.1 percent of national income in high-income countries and up to 1 percent in low-income nations. However, reductions in healthcare costs and climate-related damages were found to largely offset these investments.

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Currently, school meal programs feed approximately 466 million children every day, representing around 70 percent of the global public food system. Experts warn that achieving universal coverage will require strong political commitment and consistent funding, especially in low-income countries, where fewer than one in ten children receive school meals.

“School meals are not just a nutrition programme – they are a powerful lever for transforming food systems,” said Silvia Pastorino, diets and planetary health lead for the Research Consortium for School Health and Nutrition and a researcher at the London School of Hygiene & Tropical Medicine. “When meals are healthy, sustainable and linked to food education, they improve children’s wellbeing today and foster long-term sustainable habits, while helping countries protect biodiversity, reduce emissions and build resilient communities.”

The research consortium is part of the School Meals Coalition, an initiative led by France and Finland, formed in 2021 after more than 100 countries pledged to provide a healthy school meal for every child by 2030. The consortium is also developing a “Planet-Friendly School Meals Toolkit” to help countries evaluate costs, health benefits, and environmental impacts of sustainable school meal programs, with first results expected in spring 2026.

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From Functional Drinks to LED Masks: The Biggest Health Trends of 2025 and What Experts Say

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As 2025 comes to a close, social media continues to shape the way people eat, drink, rest, and optimise their health, with platforms like TikTok, Instagram, and Reddit driving a mix of revived and new wellness trends. Some have gone viral for their novelty, while others raise questions about effectiveness and safety.

One of the most visible trends has been “loaded water” or “enhanced water,” which combines plain water with electrolytes, flavourings, supplements, coconut water, or fruit. Proponents claim it boosts energy, digestion, and focus. Nutrition experts caution that most people do not need daily electrolyte supplements, as the body regulates these naturally. “Excessive intake of some electrolytes, such as sodium and potassium, may be risky for people with high blood pressure or kidney disease,” dietitian Helen Tieu told Healthline. She recommends using whole fruit over syrups or powders and keeping sugar content low.

Diet trends such as the carnivore and “lion” diets, which limit consumption to meat, eggs, dairy, or in the lion diet, just beef, salt, and water, have also gained attention. Advocates claim these diets improve gut health, sleep, and skin, but experts warn of significant risks. Dr Bhavini Shah from LloydsPharmacy Online Doctor described the carnivore diet as unbalanced, noting overconsumption of meat is linked to high blood pressure, cholesterol, cardiovascular disease, and Type-2 diabetes. Research from Harvard and MIT found processed red meat accelerated cognitive ageing by 1.6 years per average serving, while substituting nuts or legumes lowered dementia risk.

In skincare, at-home LED masks have become a popular tool, offering red, blue, or near-infrared light therapy. Consultant dermatologist Dr Jonathan Kentley said the technology can trigger collagen production and reduce acne, while Dr Justine Kluk warned that benefits remain modest and long-term studies are limited. Dermatologist Janiene Luke added that at-home masks are not as effective as clinical treatments but can complement prescription regimens.

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Functional drinks, including mushroom coffees and CBD-infused beverages, also went mainstream, with ingredients like ashwagandha, Lion’s Mane, magnesium, and L-theanine marketed for stress relief, focus, and calm. Nicole Cucco, a registered dietitian, said some evidence supports these ingredients, particularly for stress or attention, but effects often depend on individual deficiencies or placebo influence. She urged consumers to research products carefully rather than rely solely on marketing claims.

Other viral wellness habits, such as “bed rotting” — spending extended periods resting or sleeping as a form of self-care — reflect a broader trend toward mental health and downtime. Experts note these practices can be beneficial if balanced with activity, but they are no substitute for medical guidance or structured routines.

As 2025 ends, it is clear that health trends online can be fun and sometimes helpful, but experts emphasize that evidence and moderation remain essential when adopting new wellness practices.

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