Health
Diamond Sensors Offer New Hope for Tracing Breast Cancer Spread
UK researchers have developed a novel diamond-based sensor that could transform the way doctors track the spread of breast cancer, offering a safer and less invasive alternative to existing methods.
When breast cancer spreads, it often first reaches the lymph nodes near the tumour. Determining whether cancer has metastasised to these nodes is a critical step in treatment planning. Traditionally, doctors have relied on radioactive tracers or fluorescent dyes to identify affected nodes. However, these methods come with drawbacks: some patients are allergic to the dyes, while the use of radioactive materials requires specialised facilities and safety precautions that are not always available in hospitals.
The new technique, designed by scientists at the University of Warwick, uses tiny diamond sensors to trace the cancer’s route. Before or during surgery, doctors could inject a magnetic tracer fluid into the tumour. This liquid travels through the lymphatic system, mimicking the movement of cancer cells. The breakthrough lies in a diamond-tipped magnetic field sensor that can then detect the tracer inside the lymph nodes, allowing surgeons to identify which ones need removal.
Diamonds contain unique properties known as nitrogen vacancy centres, or colour centres, that are highly sensitive to changes in magnetic fields. These centres not only make diamonds an effective detector but also give them a distinct pink hue. “These colour centres allow the diamond to detect very small changes in magnetic field and give the diamonds a lovely pink colour,” explained Professor Gavin Morley, a physicist at the University of Warwick and one of the study’s authors.
The Warwick team succeeded in miniaturising the sensor’s tip to just 10 millimetres, making it small enough for use in surgery while retaining the sensitivity needed to detect magnetic tracer fluids. This marks the first time a diamond-based sensor of this size has been capable of detecting the tracers, according to the study published in Physical Review Applied.
Importantly, the researchers stressed that their work did not receive financial support from Endomagnetics Ltd, the company that manufactures the magnetic tracer used in the experiments.
Experts in the field have welcomed the development. Dr Stuart Robertson, a breast cancer surgeon in England, noted that magnetic sensors are already widely used to assess whether breast cancer has spread. The diamond sensor, he said, could further “optimise magnetic technology” and improve surgical outcomes.
If proven effective in clinical settings, the diamond-based sensors could provide doctors with a safer, non-radioactive tool to guide treatment while sparing patients from potential side effects associated with current techniques. The innovation adds to the growing use of magnetic technologies in oncology, raising hopes for more precise and patient-friendly cancer care in the future.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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