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Chronic Insomnia Linked to Faster Brain Ageing, Study Finds

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Struggling with sleepless nights may do more than leave you feeling tired. A new study has found that chronic insomnia is linked to faster brain ageing and a higher risk of cognitive decline.

The research, published in the journal Neurology, showed that people with chronic insomnia — defined as difficulty sleeping at least three nights a week for three months or longer — were 40% more likely to develop dementia or mild cognitive problems than those who slept normally. On average, this translated to an additional 3.5 years of brain ageing.

“These findings add to a growing body of evidence that sleep isn’t just about rest — it’s also about brain resilience,” said Dr Diego Z. Carvalho, study author and neurologist at the Mayo Clinic in the United States.

Carvalho’s team followed 2,750 older adults who were cognitively healthy at the start of the study. Over nearly six years, participants underwent regular memory and thinking tests, with some also receiving brain scans. Around 16% had chronic insomnia.

By the end of the study, 14% of people with insomnia had developed dementia or mild cognitive impairment, compared with 10% of those without sleep problems. People with chronic insomnia also showed faster declines on thinking tests.

Brain scans revealed further clues. Participants reporting less sleep than usual were more likely to have white matter hyperintensities — bright spots indicating small blood vessel damage — and amyloid plaques, protein build-ups associated with Alzheimer’s disease. The study noted that the levels of amyloid in these participants were similar to those found in carriers of the APOE4 gene variant, which raises the risk of Alzheimer’s.

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“Our results suggest that insomnia may affect the brain in different ways, involving not only amyloid plaques but also small vessels supplying blood to the brain,” Carvalho said.

Importantly, the study did not prove that insomnia directly causes dementia, only that the two appear to be connected. Researchers controlled for other factors such as age, high blood pressure, sleep apnoea, and the use of sleep medication, but further studies are needed to understand why poor sleep and brain health are linked.

The findings contribute to a broader body of research showing that poor sleep can raise the risk of several health conditions, including high blood pressure, heart disease, diabetes, depression, and obesity.

Globally, dementia affects an estimated 57 million people, according to the World Health Organization, while insomnia impacts more than 16% of the population in countries with reliable data.

“This study reinforces the importance of treating chronic insomnia — not just to improve sleep quality, but potentially to protect brain health as we age,” Carvalho said.

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Study Finds AI Systems Can Repeat Fake Medical Claims When Framed Credibly

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“Large language models accept fake medical claims if presented as realistic in medical notes and social media discussions, a study has found.”

As more people turn to the internet to research symptoms, compare treatments and share personal health experiences, artificial intelligence tools are increasingly being used to answer medical questions. A new study warns that many of these systems remain vulnerable to medical misinformation, particularly when false claims are presented in authoritative or realistic language.

The findings, published in The Lancet Digital Health, show that leading artificial intelligence systems can mistakenly repeat incorrect medical information when it appears in formats that resemble professional healthcare documents or trusted online discussions. Researchers analysed how large language models respond when faced with false medical statements written in a credible tone.

The study examined responses from 20 widely used language models, including systems developed by OpenAI, Meta, Google, Microsoft, Alibaba and Mistral AI, as well as several models specifically fine-tuned for medical use. In total, researchers assessed more than one million prompts designed to test whether AI would accept or reject fabricated health information.

Fake statements were inserted into real hospital discharge notes, drawn from common health myths shared on Reddit, or embedded in simulated clinical scenarios written to resemble authentic healthcare guidance. Across all models tested, incorrect information was accepted around 32 percent of the time. Performance varied significantly, with smaller or less advanced models accepting false claims in more than 60 percent of cases, while more advanced systems, including ChatGPT-4o, did so in roughly 10 percent of responses.

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The researchers also found that medical fine-tuned models performed worse than general-purpose systems, raising concerns about tools designed specifically for healthcare use.

“Our findings show that current AI systems can treat confident medical language as true by default, even when it’s clearly wrong,” said Eyal Klang of the Icahn School of Medicine at Mount Sinai, one of the study’s senior authors. He added that how a claim is written often matters more to the model than whether it is accurate.

Some of the accepted misinformation could pose real risks to patients. Several models endorsed claims such as Tylenol causing autism during pregnancy, rectal garlic boosting immunity, mammograms causing cancer, and tomatoes thinning blood as effectively as prescription medication. In another case, a discharge note incorrectly advised patients with oesophageal bleeding to drink cold milk, which some models repeated without flagging safety concerns.

The study also tested how AI systems responded to flawed arguments known as fallacies. While many fallacies prompted scepticism, models were more likely to accept false claims framed as expert opinions or warnings of catastrophic outcomes.

Researchers say future work should focus on measuring how often AI systems pass on falsehoods before they are used in clinical settings. Mahmud Omar, the study’s first author, said the dataset could help developers and hospitals stress-test AI tools and track improvements over time.

The authors said stronger safeguards will be essential as AI becomes more deeply embedded in healthcare decision-making.

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Moderate Caffeine Intake Linked to Lower Dementia Risk, Study Finds

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“Moderate daily consumption of caffeine is associated with a lower risk of dementia and slower cognitive decline, according to a new study.”

Drinking coffee or tea on a regular basis may help support healthy brain ageing, researchers reported, adding to growing evidence that lifestyle and dietary factors can influence cognitive health later in life. The findings suggest that moderate caffeine intake could play a modest role in reducing the risk of dementia and preserving cognitive function over time.

The study, published in JAMA, found that consuming two to three cups of caffeinated coffee or one to two cups of tea per day was associated with up to an 18% lower risk of developing dementia. The strongest benefits were seen among participants with moderate caffeine intake, though higher levels of consumption did not appear to cause harm and showed similar protective effects.

“When searching for possible dementia prevention tools, we thought something as prevalent as coffee may be a promising dietary intervention,” said senior author Daniel Wang, an associate scientist at the Mass General Brigham Department of Medicine and an assistant professor at Harvard Medical School.

Researchers analysed data from more than 130,000 participants who underwent repeated dietary, cognitive and dementia assessments. The participants were followed for as long as 43 years, allowing the team to assess long-term patterns of coffee and tea consumption and their potential impact on cognitive health. During the follow-up period, 11,033 participants developed dementia.

The analysis showed that both men and women with the highest caffeine intake had an 18% lower risk of dementia compared with those who consumed little or no caffeine. Coffee drinkers also reported fewer symptoms of subjective cognitive decline, defined as self-perceived memory loss or confusion, with rates of 7.8% compared with 9.5% among those who drank less coffee.

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Scientists believe that coffee and tea may offer neuroprotective benefits due to bioactive compounds such as caffeine and polyphenols. These substances are thought to reduce inflammation and cellular damage, while supporting blood vessel health in the brain. Previous studies have also linked caffeine consumption to improved insulin sensitivity and better vascular function, both of which are associated with cognitive health.

The authors cautioned that the research was observational and cannot prove a direct cause-and-effect relationship. The study also did not differentiate between types of coffee or tea, or account for variations in preparation methods, including roast levels, origins or brewing techniques.

The researchers noted that early prevention remains crucial, as current dementia treatments provide limited benefit once symptoms develop. Dementia typically progresses from subjective cognitive decline to mild cognitive impairment before advancing to clinical dementia.

While the findings are encouraging, the authors stressed that caffeine consumption is only one of several factors that may help protect cognitive function with age. “Our study suggests that caffeinated coffee or tea consumption can be one piece of that puzzle,” Wang said.

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Growing Research Links Tattoos to Possible Cancer Risks, Experts Say

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Tattoos are more popular than ever, but a growing body of research suggests a connection between permanent ink and certain types of cancer. How concerned should the public be?

From tribal sleeves to lower-back butterflies, humans have been inking their skin for thousands of years. For most, the main concern has been the fear of future regrets. However, recent studies suggest that tattoos could carry more serious long-term health risks.

The popularity of tattoos has risen sharply in recent years. Research published in the European Journal of Public Health estimates that between 13 and 21 percent of people in Western Europe now have at least one tattoo. Despite this prevalence, relatively little is known about the potential long-term effects of permanent ink.

Previous studies have shown that tattoo pigments can accumulate in the lymph nodes, sometimes causing inflammation and, in rare cases, lymphoma—a type of blood cancer. A 2025 study by the University of Southern Denmark (SDU) expanded on this, reporting that individuals with tattoos may face higher risks of skin cancer and lymphoma. Using a cohort of randomly selected twins, the researchers found that tattooed participants had nearly four times the risk of skin cancer compared with their non-tattooed siblings.

The study also suggested that tattoo size could affect risk, with designs larger than the palm associated with higher hazard rates.

“We have evidence that there is an association [between the amount of ink and risk] for lymphoma and for skin cancer,” said Signe Bedsted Clemmensen, co-author of the study and assistant professor of biostatistics at SDU. “For lymphoma, the hazard rate is 2.7 times higher, so this is quite a lot. And for skin cancers, before it was 1.6 and now it’s 2.4. This indicates that the more ink you have, the higher the risk, the higher the hazard rate.”

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Clemmensen emphasized that these findings remain preliminary, with many variables—including ink types, tattoo placement, and genetic and environmental factors—still under investigation. “The bottom line is, more research is needed,” she said. “But also, the next step I think is studying the biological mechanisms [of getting tattooed] and trying to understand what happens there.”

Experts also note other risks unrelated to cancer. Tattoo inks consist of pigments combined with a carrier fluid to deposit color into the dermis. Some inks, often imported, can contain trace amounts of heavy metals such as nickel, chromium, cobalt, and lead, which can trigger allergic reactions or immune sensitivity. In 2022, the European Union restricted more than 4,000 hazardous substances in tattoo inks under its REACH regulations.

While tattoos are generally considered safe when applied hygienically, the long-term health consequences remain uncertain. “It’s up to each of us how we choose to live our lives, right? But as a researcher, it’s also my job to inform people of these risks,” Clemmensen said. “Or, when it comes to tattooing, right now it’s more about informing people about how little we know.”

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