Health
Study Finds Weight-Loss Drugs May Protect Heart After Attack
Weight-loss medications commonly prescribed for diabetes and obesity may also help patients recover after a heart attack by improving blood flow and reducing the risk of complications, according to new research.
A study led by scientists at Bristol Medical School found that GLP-1 receptor agonists can help prevent further damage to heart tissue following emergency treatment. The findings were published in the journal Nature Communications.
“In nearly half of all heart attack patients, tiny blood vessels within the heart muscle remain narrowed, even after the main artery is cleared during emergency medical treatment,” said lead author Svetlana Mastitskaya. This condition, known as “no-reflow,” prevents oxygen-rich blood from reaching parts of the heart, increasing the risk of long-term damage.
The research team conducted experiments in rodents and tested their results using cultivated human heart cells. They found that GLP-1 drugs improved blood flow by activating potassium channels and relaxing pericytes, the muscle cells that surround small blood vessels in the heart. When these cells relax, constricted vessels can widen, allowing blood to circulate more effectively.
GLP-1 receptor agonists mimic a hormone produced naturally in the body that helps regulate blood sugar and appetite. They are widely used to treat type 2 diabetes and to promote weight loss by helping patients feel full for longer periods.
Previous studies have shown that people taking GLP-1 medications have a lower risk of cardiovascular diseases, including heart attacks and strokes. In 2024, the US Food and Drug Administration approved the use of Wegovy, a semaglutide-based GLP-1 drug, to reduce the risk of stroke, heart attack and other cardiovascular conditions.
Clinical trials have indicated that the heart benefits of these medications appear to be independent of the amount of weight lost. Patients taking the drugs experienced fewer heart attacks and strokes regardless of whether they were mildly overweight or severely obese.
Researchers believe GLP-1 drugs may lower cardiovascular risk by reducing inflammation, improving blood pressure control, lowering cholesterol and other blood fats, and supporting the health of blood vessels.
Despite these promising findings, experts stress that medication alone is not enough. A recent study from Harvard University found that patients with type 2 diabetes who combined GLP-1 treatment with healthy lifestyle habits saw significantly greater heart health benefits. Those who followed eight key habits, including a balanced diet, regular exercise, adequate sleep and avoiding smoking, had a 60 percent lower risk compared with those who followed one or none.
Frank Hu, one of the study’s authors, said the results show that healthy living remains central to reducing cardiovascular risk, even with modern drug therapies.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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