Health
Study Finds Weight-Loss Drugs May Protect Heart After Attack
Weight-loss medications commonly prescribed for diabetes and obesity may also help patients recover after a heart attack by improving blood flow and reducing the risk of complications, according to new research.
A study led by scientists at Bristol Medical School found that GLP-1 receptor agonists can help prevent further damage to heart tissue following emergency treatment. The findings were published in the journal Nature Communications.
“In nearly half of all heart attack patients, tiny blood vessels within the heart muscle remain narrowed, even after the main artery is cleared during emergency medical treatment,” said lead author Svetlana Mastitskaya. This condition, known as “no-reflow,” prevents oxygen-rich blood from reaching parts of the heart, increasing the risk of long-term damage.
The research team conducted experiments in rodents and tested their results using cultivated human heart cells. They found that GLP-1 drugs improved blood flow by activating potassium channels and relaxing pericytes, the muscle cells that surround small blood vessels in the heart. When these cells relax, constricted vessels can widen, allowing blood to circulate more effectively.
GLP-1 receptor agonists mimic a hormone produced naturally in the body that helps regulate blood sugar and appetite. They are widely used to treat type 2 diabetes and to promote weight loss by helping patients feel full for longer periods.
Previous studies have shown that people taking GLP-1 medications have a lower risk of cardiovascular diseases, including heart attacks and strokes. In 2024, the US Food and Drug Administration approved the use of Wegovy, a semaglutide-based GLP-1 drug, to reduce the risk of stroke, heart attack and other cardiovascular conditions.
Clinical trials have indicated that the heart benefits of these medications appear to be independent of the amount of weight lost. Patients taking the drugs experienced fewer heart attacks and strokes regardless of whether they were mildly overweight or severely obese.
Researchers believe GLP-1 drugs may lower cardiovascular risk by reducing inflammation, improving blood pressure control, lowering cholesterol and other blood fats, and supporting the health of blood vessels.
Despite these promising findings, experts stress that medication alone is not enough. A recent study from Harvard University found that patients with type 2 diabetes who combined GLP-1 treatment with healthy lifestyle habits saw significantly greater heart health benefits. Those who followed eight key habits, including a balanced diet, regular exercise, adequate sleep and avoiding smoking, had a 60 percent lower risk compared with those who followed one or none.
Frank Hu, one of the study’s authors, said the results show that healthy living remains central to reducing cardiovascular risk, even with modern drug therapies.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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