Health
Study Finds Weight-Loss Drugs May Protect Heart After Attack
Weight-loss medications commonly prescribed for diabetes and obesity may also help patients recover after a heart attack by improving blood flow and reducing the risk of complications, according to new research.
A study led by scientists at Bristol Medical School found that GLP-1 receptor agonists can help prevent further damage to heart tissue following emergency treatment. The findings were published in the journal Nature Communications.
“In nearly half of all heart attack patients, tiny blood vessels within the heart muscle remain narrowed, even after the main artery is cleared during emergency medical treatment,” said lead author Svetlana Mastitskaya. This condition, known as “no-reflow,” prevents oxygen-rich blood from reaching parts of the heart, increasing the risk of long-term damage.
The research team conducted experiments in rodents and tested their results using cultivated human heart cells. They found that GLP-1 drugs improved blood flow by activating potassium channels and relaxing pericytes, the muscle cells that surround small blood vessels in the heart. When these cells relax, constricted vessels can widen, allowing blood to circulate more effectively.
GLP-1 receptor agonists mimic a hormone produced naturally in the body that helps regulate blood sugar and appetite. They are widely used to treat type 2 diabetes and to promote weight loss by helping patients feel full for longer periods.
Previous studies have shown that people taking GLP-1 medications have a lower risk of cardiovascular diseases, including heart attacks and strokes. In 2024, the US Food and Drug Administration approved the use of Wegovy, a semaglutide-based GLP-1 drug, to reduce the risk of stroke, heart attack and other cardiovascular conditions.
Clinical trials have indicated that the heart benefits of these medications appear to be independent of the amount of weight lost. Patients taking the drugs experienced fewer heart attacks and strokes regardless of whether they were mildly overweight or severely obese.
Researchers believe GLP-1 drugs may lower cardiovascular risk by reducing inflammation, improving blood pressure control, lowering cholesterol and other blood fats, and supporting the health of blood vessels.
Despite these promising findings, experts stress that medication alone is not enough. A recent study from Harvard University found that patients with type 2 diabetes who combined GLP-1 treatment with healthy lifestyle habits saw significantly greater heart health benefits. Those who followed eight key habits, including a balanced diet, regular exercise, adequate sleep and avoiding smoking, had a 60 percent lower risk compared with those who followed one or none.
Frank Hu, one of the study’s authors, said the results show that healthy living remains central to reducing cardiovascular risk, even with modern drug therapies.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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