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Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds

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Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.

The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.

Increased Risk of Relapse and Mortality

The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.

“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.

Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.

Acute Lymphoblastic Leukemia and Brain Tumors Most Affected

The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.

Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.

Limitations and Calls for Improved Measures

The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.

“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.

Implications and Urgency

The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.

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Drug-Resistant Superbugs Kill Thousands Across Europe, Threatening Medical Progress

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Drug-resistant infections are causing more than 35,000 deaths annually across Europe, and health authorities warn the growing threat could undo years of medical progress.

Antimicrobial resistance (AMR) occurs when bacteria, viruses, and other pathogens evolve to survive existing treatments, making infections harder to treat. The resistance also increases risks for patients undergoing procedures such as organ transplants, chemotherapy, and complex surgeries.

The European Centre for Disease Prevention and Control (ECDC) released estimates on Tuesday showing that AMR contributes to tens of thousands of fatalities each year across the European Union, Iceland, Liechtenstein, and Norway. The agency described a “perfect storm” driving the rise in resistance: an ageing population more vulnerable to infections, cross-border spread of drug-resistant pathogens, overuse of antibiotics by doctors and patients, and gaps in infection prevention and control measures.

“We must ensure that no one in Europe is left without an effective treatment option,” said Dr. Diamantis Plachouras, who leads the ECDC’s work on AMR and healthcare-associated infections.

The EU Council set five targets in 2023 to combat AMR, including curbing overall antibiotic use, ensuring at least 65 per cent of antibiotics are first-line treatments, and reducing bloodstream infections from three drug-resistant bacteria. The new report shows that Europe has met only one of these goals.

Bloodstream infections caused by meticillin-resistant Staphylococcus aureus (MRSA) have fallen by 20.4 per cent since 2019, surpassing the target reduction of 15 per cent. However, new bloodstream infections from carbapenem-resistant Klebsiella pneumoniae have risen by over 60 per cent, despite a target reduction of 5 per cent. Highly resistant strains of Escherichia coli (E. coli) have also increased by more than 5 per cent, against a reduction goal of 10 per cent.

Antibiotic use across Europe has risen, including drugs meant only as last-resort treatments. This trend, combined with a shortage of new antibiotics for high-priority pathogens such as carbapenem-resistant gram-negative bacteria (CR-GNB), has left health systems struggling to keep infections under control.

ECDC Director Dr. Pamela Rendi-Wagner said urgent action is needed to curb resistance and support medical advances. “Tackling AMR requires critical innovation,” she said. She called for increased investment in promoting responsible antibiotic use, strengthening infection prevention, and developing new drugs.

Experts warn that without immediate action, Europe could face mounting deaths and rising healthcare costs. AMR is now seen not just as a clinical challenge but as a public health crisis that threatens the safety of routine medical treatments and the ability of hospitals to manage serious infections effectively.

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WHO Warns of Sharp Rise in Mental Health Conditions Among Europe’s Youth

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A growing number of children and teenagers across Europe are experiencing mental health conditions, with global health officials warning that support systems are failing to keep pace with the surge. A new analysis released by the World Health Organization (WHO) outlines the scale of the challenge and calls for urgent action across the region.

According to the report, one in seven Europeans under the age of 20 are living with a mental health condition — a rise of about one-third over the past 15 years. The findings show clear gender disparities, with girls facing greater vulnerability. Among girls aged 15 to 19, one in four report having a mental health condition, making them the most affected group.

The report also highlights striking differences between countries. Teenagers in the Faroe Islands, Iceland and Denmark ranked among the highest for mental wellbeing, while those in Ukraine, Cyprus and Poland were placed at the lower end of the scale. The data reflects both long-term trends and the impact of recent crises.

Concerns about youth mental health have intensified in recent years, driven by a combination of social isolation, the effects of the COVID-19 pandemic, geopolitical tensions and growing economic pressures. Experts say these factors have created an environment in which young people are increasingly exposed to stress and uncertainty.

Access to professional support remains one of the region’s biggest obstacles. The WHO report notes that about one-quarter of European countries do not have community-based mental health services for young people. In addition, one in five countries lack dedicated mental health policies, leaving many children and teenagers without structured pathways to receive help.

“This report is a wake-up call,” said Dr. João Breda, who works on patient safety and healthcare quality at the WHO. “Every child and young person has the right to mental health support and high-quality care.”

The findings mark the first time the WHO has compiled extensive data on child and youth mental health across its European region, which includes 53 countries in Europe and Central Asia. The report stresses the need for stronger in-person care, noting rising concerns about young people turning to digital tools for emotional support. The document raises alarms about cases in which reliance on artificial intelligence chatbots, including ChatGPT, has led to harmful outcomes.

The WHO is urging governments to strengthen their mental health frameworks by increasing investment, expanding services and updating programmes to better reflect the needs of children and adolescents.

“By acting now, countries can build resilient systems that help the next generations thrive,” Breda said.

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Poliovirus Detected in Hamburg Wastewater, Raising Public Health Alerts

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Health authorities in Germany have discovered traces of the poliovirus in sewage from Hamburg, highlighting a persistent health threat decades after Europe was declared polio-free. The finding has prompted renewed calls for enhanced disease monitoring and vaccination coverage.

Germany has not reported any confirmed cases of poliomyelitis, a highly contagious disease that primarily affects young children and can invade the nervous system, sometimes causing paralysis. The poliovirus detected in Hamburg’s wastewater is genetically similar to a strain last identified in Afghanistan, one of only two countries where polio remains endemic.

The European Centre for Disease Prevention and Control (ECDC) described the detection as “unusual, but not unexpected.” Germany’s last known locally transmitted polio case occurred in 1990, and the continent was officially declared polio-free in 2002. However, health officials caution that imported cases remain possible, particularly among populations with low vaccination coverage.

The World Health Organization (WHO) emphasized that the discovery underscores the ongoing risk: “Until polio is eradicated everywhere, all countries remain at risk of importation of the virus and potential re-infection.” Poliovirus can appear in sewage when individuals shed the virus in their stool. This does not necessarily indicate illness, as it can also result from people receiving the oral polio vaccine, which contains a weakened live virus.

Last year, similar detections in Germany, Poland, and Spain prompted health authorities to urge countries to strengthen surveillance systems and vaccination campaigns to protect populations from potential outbreaks. Across the European Union, vaccination coverage among one-year-olds ranged from 79 percent in Romania to 99 percent in Hungary and Luxembourg, according to WHO data. Experts note that gaps may persist at the local level, leaving some communities vulnerable to transmission.

Despite the presence of the virus in sewage, the ECDC stressed that the overall risk to the European population remains “very low.” Health authorities are using the findings to monitor trends and reinforce vaccination messaging, particularly in areas where immunization rates fall below recommended levels.

Germany’s recent detection serves as a reminder that polio, although rare in Europe, has not been fully eliminated globally. Public health officials continue to advocate for robust immunization programs, vigilant disease surveillance, and rapid response plans to prevent the virus from spreading should a case arise.

The Hamburg wastewater discovery has renewed focus on the importance of vaccination and monitoring, reinforcing global efforts to ensure that polio remains under control until it is eradicated worldwide.

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