Health
Five Years On: COVID-19 Pandemic Leaves Lingering Mysteries and Challenges
More than five years after the first cluster of COVID-19 cases emerged in Wuhan, China, the virus continues to evolve, leaving behind unanswered questions and a legacy of global disruption. The pandemic reshaped public health policies, exposed systemic inequities, and brought groundbreaking advances in vaccine development.
Origins of the Virus Remain Unclear
The origins of SARS-CoV-2, the virus causing COVID-19, remain uncertain. While scientists believe it likely originated in bats and was transmitted to humans through an intermediary species such as raccoon dogs or civet cats, this theory remains unproven. Speculation about a potential laboratory leak in Wuhan has further fueled political tensions.
The World Health Organization (WHO) recently urged China to share more data, calling transparency a “moral and scientific imperative” to help prevent future pandemics. However, experts caution that the true origin may never be definitively established.
Global Death Toll and Vaccination Efforts
The pandemic’s death toll remains staggering. While the WHO reports over seven million deaths worldwide, the actual number is estimated to exceed 20 million. Vulnerable populations, especially older adults, continue to account for a significant proportion of fatalities.
Despite these losses, the rapid development of COVID-19 vaccines has saved tens of millions of lives. The introduction of mRNA vaccines by Pfizer and Moderna in less than a year marked a scientific milestone, with more than 13 billion doses administered globally since 2021.
Vaccines have proven effective in reducing severe illness, hospitalizations, and deaths, though their protection against mild infections wanes over time. Researchers are working on next-generation vaccines, including nasal options, to better prevent infections.
Variants and Virus Evolution
The virus has continually mutated, with the omicron variant and its subvariants dominating since late 2021. Currently, KP.3 and a hybrid strain, XEC, are the primary variants in Europe. While these variants remain highly transmissible, existing vaccines and treatments have shown efficacy against them.
Long COVID: A Lingering Concern
Millions globally continue to grapple with long COVID, a condition characterized by persistent symptoms such as fatigue, brain fog, and cardiovascular issues. While vaccination reduces the risk, the root cause of long COVID remains unclear, complicating efforts to develop effective treatments.
Emerging research suggests remnants of the virus may linger in some patients’ bodies, offering clues but no definitive answers.
Looking Ahead
As humanity adjusts to a world where COVID-19 is no longer a leading cause of death but still a public health concern, the focus remains on monitoring variants, improving treatments, and addressing the long-term effects of the virus.
“The virus is still with us,” said WHO Director-General Tedros Adhanom Ghebreyesus. “We cannot talk about COVID in the past.”
Health
Study Finds AI Systems Can Repeat Fake Medical Claims When Framed Credibly
“Large language models accept fake medical claims if presented as realistic in medical notes and social media discussions, a study has found.”
As more people turn to the internet to research symptoms, compare treatments and share personal health experiences, artificial intelligence tools are increasingly being used to answer medical questions. A new study warns that many of these systems remain vulnerable to medical misinformation, particularly when false claims are presented in authoritative or realistic language.
The findings, published in The Lancet Digital Health, show that leading artificial intelligence systems can mistakenly repeat incorrect medical information when it appears in formats that resemble professional healthcare documents or trusted online discussions. Researchers analysed how large language models respond when faced with false medical statements written in a credible tone.
The study examined responses from 20 widely used language models, including systems developed by OpenAI, Meta, Google, Microsoft, Alibaba and Mistral AI, as well as several models specifically fine-tuned for medical use. In total, researchers assessed more than one million prompts designed to test whether AI would accept or reject fabricated health information.
Fake statements were inserted into real hospital discharge notes, drawn from common health myths shared on Reddit, or embedded in simulated clinical scenarios written to resemble authentic healthcare guidance. Across all models tested, incorrect information was accepted around 32 percent of the time. Performance varied significantly, with smaller or less advanced models accepting false claims in more than 60 percent of cases, while more advanced systems, including ChatGPT-4o, did so in roughly 10 percent of responses.
The researchers also found that medical fine-tuned models performed worse than general-purpose systems, raising concerns about tools designed specifically for healthcare use.
“Our findings show that current AI systems can treat confident medical language as true by default, even when it’s clearly wrong,” said Eyal Klang of the Icahn School of Medicine at Mount Sinai, one of the study’s senior authors. He added that how a claim is written often matters more to the model than whether it is accurate.
Some of the accepted misinformation could pose real risks to patients. Several models endorsed claims such as Tylenol causing autism during pregnancy, rectal garlic boosting immunity, mammograms causing cancer, and tomatoes thinning blood as effectively as prescription medication. In another case, a discharge note incorrectly advised patients with oesophageal bleeding to drink cold milk, which some models repeated without flagging safety concerns.
The study also tested how AI systems responded to flawed arguments known as fallacies. While many fallacies prompted scepticism, models were more likely to accept false claims framed as expert opinions or warnings of catastrophic outcomes.
Researchers say future work should focus on measuring how often AI systems pass on falsehoods before they are used in clinical settings. Mahmud Omar, the study’s first author, said the dataset could help developers and hospitals stress-test AI tools and track improvements over time.
The authors said stronger safeguards will be essential as AI becomes more deeply embedded in healthcare decision-making.
Health
Moderate Caffeine Intake Linked to Lower Dementia Risk, Study Finds
Health
Growing Research Links Tattoos to Possible Cancer Risks, Experts Say
Tattoos are more popular than ever, but a growing body of research suggests a connection between permanent ink and certain types of cancer. How concerned should the public be?
From tribal sleeves to lower-back butterflies, humans have been inking their skin for thousands of years. For most, the main concern has been the fear of future regrets. However, recent studies suggest that tattoos could carry more serious long-term health risks.
The popularity of tattoos has risen sharply in recent years. Research published in the European Journal of Public Health estimates that between 13 and 21 percent of people in Western Europe now have at least one tattoo. Despite this prevalence, relatively little is known about the potential long-term effects of permanent ink.
Previous studies have shown that tattoo pigments can accumulate in the lymph nodes, sometimes causing inflammation and, in rare cases, lymphoma—a type of blood cancer. A 2025 study by the University of Southern Denmark (SDU) expanded on this, reporting that individuals with tattoos may face higher risks of skin cancer and lymphoma. Using a cohort of randomly selected twins, the researchers found that tattooed participants had nearly four times the risk of skin cancer compared with their non-tattooed siblings.
The study also suggested that tattoo size could affect risk, with designs larger than the palm associated with higher hazard rates.
“We have evidence that there is an association [between the amount of ink and risk] for lymphoma and for skin cancer,” said Signe Bedsted Clemmensen, co-author of the study and assistant professor of biostatistics at SDU. “For lymphoma, the hazard rate is 2.7 times higher, so this is quite a lot. And for skin cancers, before it was 1.6 and now it’s 2.4. This indicates that the more ink you have, the higher the risk, the higher the hazard rate.”
Clemmensen emphasized that these findings remain preliminary, with many variables—including ink types, tattoo placement, and genetic and environmental factors—still under investigation. “The bottom line is, more research is needed,” she said. “But also, the next step I think is studying the biological mechanisms [of getting tattooed] and trying to understand what happens there.”
Experts also note other risks unrelated to cancer. Tattoo inks consist of pigments combined with a carrier fluid to deposit color into the dermis. Some inks, often imported, can contain trace amounts of heavy metals such as nickel, chromium, cobalt, and lead, which can trigger allergic reactions or immune sensitivity. In 2022, the European Union restricted more than 4,000 hazardous substances in tattoo inks under its REACH regulations.
While tattoos are generally considered safe when applied hygienically, the long-term health consequences remain uncertain. “It’s up to each of us how we choose to live our lives, right? But as a researcher, it’s also my job to inform people of these risks,” Clemmensen said. “Or, when it comes to tattooing, right now it’s more about informing people about how little we know.”
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