Health
Weight Fluctuations in Older Adults Linked to Faster Cognitive Decline, Study Finds
Older adults who lose weight or experience significant fluctuations may face an increased risk of accelerated cognitive decline, according to new research from Pennsylvania State University.
The study, published in the journal Obesity, found that individuals aged 65 and above who were underweight or whose body weight shifted by more than 5% over time experienced faster deterioration in memory, orientation, and executive function than peers who maintained a stable weight.
“We examined 11 years of data on weight, BMI and waist circumference,” said Muzi Na, associate professor of nutritional sciences and the study’s senior author. “Any way we looked at the data, the relationship was crystal clear — the more a person’s weight varied from year to year, the faster that person experienced cognitive decline.”
The findings are based on health data collected between 2011 and 2021 from 4,304 participants in the US National Health and Aging Study. Researchers assessed cognitive performance using a composite index derived from standardized tests of memory, orientation, and executive skills.
Participants who maintained a stable weight had the lowest rates of cognitive decline. In contrast, those with the greatest weight variability were found to have two to four times higher rates of decline. Losing more than 5% of body weight, or repeatedly gaining and losing that amount, was also strongly linked to faster decline. Interestingly, older adults who only gained weight did not show increased cognitive deterioration compared with those who remained stable — though researchers stressed that this should not be interpreted as a reason to gain weight.
“Mid-life obesity is a known risk factor for cognitive decline later in life, but there is an ‘obesity paradox,’ where late-life obesity has sometimes been associated with healthier cognitive trajectories,” Na explained. “Our study does not suggest older adults should gain weight. Rather, it highlights the complex interplay between muscle loss and fat gain in aging populations.”
The research team emphasized that regular weight monitoring could serve as an early warning signal for protecting brain health. However, they also cautioned that weight checks at routine medical visits may not always provide consistent results.
“To make sure you understand what is happening to your body and brain, older adults should track their weight at home in a more consistent way,” Na said. “For example, weighing yourself at the same time each morning — before breakfast, after using the bathroom, and in the same clothing — can provide more reliable data.”
The study adds to growing evidence that maintaining physical stability in later life, including steady body weight, may help slow cognitive decline and preserve quality of life in aging populations.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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