Health
New Study Finds LSD Shows Promise in Treating Anxiety Disorders
The psychedelic drug LSD has shown encouraging results in reducing symptoms of generalized anxiety disorder, according to a new study that could pave the way for its eventual medical approval in the United States. The research, conducted by biotechnology company Mindmed and published in the Journal of the American Medical Association, is the most significant evidence in decades supporting the therapeutic potential of LSD, which has been banned in the U.S. for more than 50 years.
The mid-stage clinical trial involved nearly 200 patients with moderate-to-severe anxiety. Participants received one of four doses of LSD or a placebo, administered under professional supervision. Researchers tracked the patients over three months to evaluate changes in anxiety levels. Results showed that patients who received the two highest doses of LSD reported significantly lower anxiety scores than those given placebo or lower doses. At the 12-week mark, 65 percent of those who received the most effective dose—100 micrograms—continued to show benefits, with nearly half in remission.
Dr. Maurizio Fava of Mass General Brigham Hospital, the study’s lead author and an adviser to Mindmed, said the findings were notable for their durability. “It’s possible that some people may need retreatment,” Fava said, “but the long-lasting effect is quite significant.”
The study also highlighted potential side effects, including hallucinations, nausea, and headaches. A further complication was that most participants were able to guess whether they had received LSD or placebo, raising questions about the integrity of the trial’s “blinded” design. Dropout rates were also high, narrowing the final data set.
Still, experts view the study as an important step forward. “I see this paper as a clear step in reviving old research, but with modern standards,” said Frederick Barrett, director of Johns Hopkins University’s Center for Psychedelic and Consciousness Research, who was not involved in the trial.
Interest in psychedelics as treatments for mental health conditions has surged in recent years. The U.S. Food and Drug Administration (FDA) has already granted “breakthrough therapy” status to psilocybin and MDMA, and LSD now joins the list of candidates. However, approval is far from guaranteed. Last year, the FDA rejected MDMA for treating PTSD, citing flaws in study methods and concerns about bias.
Unlike other psychedelic studies, which often combine drug treatment with extended talk therapy, Mindmed’s trial tested LSD alone, under supervision but without therapy sessions. That simpler approach may help regulators isolate the drug’s effects.
Mindmed has already launched two larger, late-stage studies designed to confirm these findings and assess how long the benefits last. If successful, the company plans to seek FDA approval.
Generalized anxiety disorder affects nearly 3 percent of U.S. adults, according to the National Institutes of Health. Current treatments include psychotherapy, antidepressants, and anti-anxiety medications such as benzodiazepines, though many patients struggle with limited effectiveness or side effects.
“LSD was always right there, but Mindmed is the first company to rigorously evaluate it in modern trials,” Fava said. “These results suggest it may hold real promise as a treatment option.”
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
AI Models Show Ability to Mimic Human Emotions, Offering New Pathways for Mental Health Research
Health
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