Health
Study Finds Human Blood Cells Age Faster in Space
Human blood cells exposed to space conditions begin to lose their ability to generate healthy new cells and show signs of genetic damage, according to new research backed by NASA. The findings raise concerns about the biological toll of long-duration space travel and its potential impact on astronaut health.
The study, published in Cell Stem Cell, tracked changes in blood-forming stem cells during four SpaceX missions to the International Space Station (ISS). Researchers used haematopoietic stem and progenitor cells (HSPCs), which are crucial for producing blood and maintaining immune function.
When these cells spent 32 to 45 days in space, they began to display hallmarks of accelerated ageing. This included reduced capacity to generate healthy new cells, DNA damage, and shorter telomeres — protective caps on chromosomes that naturally shorten with age.
“Space is the ultimate stress test for the human body,” said Dr. Catriona Jamieson, study co-author and director of the Sanford Stem Cell Institute at the University of California San Diego. “Our findings show that the stressors of space — including microgravity and cosmic radiation — can accelerate the molecular ageing of blood stem cells.”
Using AI to Track Ageing in Space
The team used artificial intelligence-powered imaging tools to monitor cellular changes in real time during the missions. By studying HSPCs in microgravity, they were able to observe how quickly biological deterioration can occur outside Earth’s atmosphere.
Interestingly, some of the damage appeared to reverse when the cells were returned to Earth and placed in healthier environments. This suggests that while space accelerates cellular ageing, certain effects may be at least partially reversible.
Implications for Astronauts and Space Travel
The findings highlight the urgent need to develop countermeasures to protect astronauts as space agencies and private companies push for longer missions to the Moon, Mars, and beyond.
“Understanding these changes not only informs how we protect astronauts during long-duration missions but also helps us model human ageing and diseases like cancer here on Earth,” Jamieson noted.
The next phase of research will investigate whether similar molecular changes occur in astronauts themselves. Scientists hope to identify medical or genetic interventions that could mitigate the harmful effects of prolonged exposure to microgravity and cosmic radiation.
A New Era of Space Medicine
As commercial spaceflight expands and research in low Earth orbit grows, the health risks of space travel are becoming more pressing. The study suggests that prolonged stays in orbit could increase vulnerability to age-related conditions and weaken immune systems, underscoring the need for new medical strategies.
“This is essential knowledge as we enter a new era of commercial space travel,” Jamieson added. “Protecting human health in space will be as important as developing the technology to get us there.”
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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