Health
Artificial Sweeteners Linked to Faster Cognitive Decline, Study Finds
Artificial sweeteners found in diet sodas and low-calorie desserts may be linked to faster cognitive decline, according to new research published in the medical journal of the American Academy of Neurology.
The study, which tracked nearly 13,000 adults in Brazil over an average of eight years, found that people who consumed the highest amounts of artificial sweeteners experienced cognitive decline 62 per cent faster than those with the lowest intake. The decline was equivalent to around 1.6 years of ageing in terms of memory, language, and thinking skills.
“Low- and no-calorie sweeteners are often seen as a healthy alternative to sugar,” said lead author Claudia Kimie Suemoto, associate professor of geriatrics at the University of São Paulo. “However, our findings suggest certain sweeteners may have negative effects on brain health over time.”
The Study
Participants, who had an average age of 52 at the start, underwent repeated tests assessing cognitive function. They were divided into three groups based on sweetener consumption. The lowest-intake group consumed about 20 mg per day, while the highest group averaged 191 mg daily — roughly the amount of aspartame in a single can of diet soda.
Researchers examined several common sweeteners, including aspartame, saccharin, acesulfame-K, erythritol, xylitol, and sorbitol. All were linked to accelerated cognitive decline except for tagatose, which showed no significant effect.
The association was more pronounced among participants with diabetes, who often rely on sugar substitutes. However, no link was observed in participants over 60 years old, suggesting that mid-life consumption may have a greater impact on long-term brain health.
Broader Concerns
The findings add to a growing body of evidence questioning the long-term safety of artificial sweeteners. Previous research has connected non-sugar sweeteners to higher risks of type 2 diabetes and cardiovascular disease.
The International Agency for Research on Cancer has already classified aspartame as a possible carcinogen, though regulators have maintained that approved sweeteners remain safe within established limits.
Still, Suemoto stressed that the current study highlights associations rather than direct cause-and-effect. “More research is needed to determine exactly how artificial sweeteners may impact the brain,” she noted.
Regulation and Next Steps
In the European Union, all sugar alternatives must undergo safety evaluations before being sold, and their presence must be indicated on food and drink labels. The European Food Safety Authority (EFSA) is currently re-assessing the safety of sweeteners approved before 2009.
The study does have limitations, including reliance on participants’ self-reported diets and a focus on selected sweeteners. Nonetheless, experts say it underscores the need for closer scrutiny of products marketed as healthier sugar substitutes.
As consumers increasingly turn to low-calorie sweeteners in pursuit of healthier lifestyles, researchers warn that the long-term effects on brain health may not be as benign as once believed.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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