Health
Artificial Sweeteners Linked to Faster Cognitive Decline, Study Finds
Artificial sweeteners found in diet sodas and low-calorie desserts may be linked to faster cognitive decline, according to new research published in the medical journal of the American Academy of Neurology.
The study, which tracked nearly 13,000 adults in Brazil over an average of eight years, found that people who consumed the highest amounts of artificial sweeteners experienced cognitive decline 62 per cent faster than those with the lowest intake. The decline was equivalent to around 1.6 years of ageing in terms of memory, language, and thinking skills.
“Low- and no-calorie sweeteners are often seen as a healthy alternative to sugar,” said lead author Claudia Kimie Suemoto, associate professor of geriatrics at the University of São Paulo. “However, our findings suggest certain sweeteners may have negative effects on brain health over time.”
The Study
Participants, who had an average age of 52 at the start, underwent repeated tests assessing cognitive function. They were divided into three groups based on sweetener consumption. The lowest-intake group consumed about 20 mg per day, while the highest group averaged 191 mg daily — roughly the amount of aspartame in a single can of diet soda.
Researchers examined several common sweeteners, including aspartame, saccharin, acesulfame-K, erythritol, xylitol, and sorbitol. All were linked to accelerated cognitive decline except for tagatose, which showed no significant effect.
The association was more pronounced among participants with diabetes, who often rely on sugar substitutes. However, no link was observed in participants over 60 years old, suggesting that mid-life consumption may have a greater impact on long-term brain health.
Broader Concerns
The findings add to a growing body of evidence questioning the long-term safety of artificial sweeteners. Previous research has connected non-sugar sweeteners to higher risks of type 2 diabetes and cardiovascular disease.
The International Agency for Research on Cancer has already classified aspartame as a possible carcinogen, though regulators have maintained that approved sweeteners remain safe within established limits.
Still, Suemoto stressed that the current study highlights associations rather than direct cause-and-effect. “More research is needed to determine exactly how artificial sweeteners may impact the brain,” she noted.
Regulation and Next Steps
In the European Union, all sugar alternatives must undergo safety evaluations before being sold, and their presence must be indicated on food and drink labels. The European Food Safety Authority (EFSA) is currently re-assessing the safety of sweeteners approved before 2009.
The study does have limitations, including reliance on participants’ self-reported diets and a focus on selected sweeteners. Nonetheless, experts say it underscores the need for closer scrutiny of products marketed as healthier sugar substitutes.
As consumers increasingly turn to low-calorie sweeteners in pursuit of healthier lifestyles, researchers warn that the long-term effects on brain health may not be as benign as once believed.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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