Health
Study Finds Calorie Restriction Can Boost Chemotherapy Effectiveness in Sarcoma Treatment
A new Portuguese-Brazilian study suggests that controlling calorie intake can improve the effectiveness of chemotherapy in treating sarcomas, a rare type of cancer, while also protecting healthy cells from treatment damage. The research, conducted by the RISE Health Research Unit in collaboration with the Federal University of Piauí in Brazil, was released on World Cancer Day, February 4, a day promoted by the International Union Against Cancer (UICC) to raise awareness of cancer prevention, early diagnosis, and access to treatments.
The study found that moderate calorie restriction, alone or in combination with chemotherapy drugs such as doxorubicin, significantly reduced tumour size and weight, increased tumour inhibition rates, and protected normal cells from chemotherapy-induced damage. Researchers reported that a 40 percent reduction in calorie intake induced metabolic stress in the tumour microenvironment, disrupting processes essential for cancer growth.
“From this experimental study, carried out on animal models, we observed that calorie restriction for short periods can be favourable to cancer treatment,” said Moisés Tolentino Bento da Silva of RISE Health, who led the research in Portugal. He explained that higher energy intake fuels cancer progression, so reducing calorie intake limits the energy supply to the tumour and enhances chemotherapy effectiveness.
The study also highlighted additional benefits of calorie restriction. It supports DNA repair in healthy tissues damaged by chemotherapy and reprogrammes lipid metabolism, lowering cholesterol and triglyceride levels that feed malignant cells. Researchers noted that these effects may also have broader implications for managing chronic conditions such as type II diabetes, cardiovascular disease, and neurodegenerative disorders.
Alongside dietary control, the study emphasized the importance of regular physical exercise during cancer treatment. “If cancer patients exercise adequately and regularly during chemotherapy, they will experience fewer side effects in various systems, such as the gastrointestinal tract,” Tolentino Bento da Silva said. “Physical exercise, together with a good diet, has great benefits for the patient’s quality of life, whether it is preventative, during treatment, or after oncological therapy.”
The research, published in the journal Cancers, provides new evidence that lifestyle interventions, including calorie management and physical activity, can complement traditional cancer therapies. While the study was conducted on animal models, the findings open pathways for clinical research and potential integration into patient care protocols.
As cancer treatment continues to evolve, experts suggest that non-pharmacological approaches such as diet and exercise may play an increasingly important role in supporting patients, improving treatment outcomes, and enhancing overall well-being during chemotherapy.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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