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Over 100 Researchers Urge Safeguards on High-Risk Biological Data Amid AI Concerns

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More than 100 scientists from leading institutions have called for stronger safeguards on sensitive biological datasets to prevent artificial intelligence (AI) from being misused to create dangerous pathogens. The open letter, signed by researchers from Johns Hopkins University, the University of Oxford, Fordham University, and Stanford University, highlights the potential biosecurity risks posed by unrestricted access to certain genetic and pathogen data.

AI models for biology rely heavily on large volumes of data, including genetic sequences and characteristics of viruses and other pathogens. While open access to such information has accelerated scientific discovery, the researchers warn that certain datasets could allow AI systems to design or enhance deadly viruses.

“The stakes of biological data governance are high, as AI models could help create severe biological threats,” the authors wrote. They describe the ability of AI to predict mutations, identify patterns, and generate more transmissible pathogen variants as a “capability of concern” that could speed up the development of biological threats affecting humans, animals, plants, or the environment.

The scientists stress that while most biological data should remain openly accessible, “concerning pathogen data” requires stricter security checks. The letter proposes a framework to define and govern high-risk datasets before they are generally available to AI developers. “Limiting access to sensitive pathogen data to legitimate researchers might be one of the most promising avenues for risk reduction,” said Moritz Hanke, co-author from Johns Hopkins University.

Currently, no universal rules govern access to these datasets. Some AI developers voluntarily exclude high-risk data from training, but approaches vary. Developers of AI models such as Evo, created by the Arc Institute, Stanford, and TogetherAI, and ESM3, from EvolutionaryScale, have withheld certain viral sequences to prevent potential misuse. In February 2025, the EVO 2 team announced that it had excluded pathogens infecting humans and complex organisms to reduce ethical and safety risks and prevent its use in bioweapon development.

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The proposed framework introduces a five-tier system, called Biosecurity Data Levels (BDL), to classify pathogen data based on risk:

  • BDL-0: Everyday biology data with no restrictions.

  • BDL-1: Basic viral building blocks; monitored access recommended.

  • BDL-2: Animal virus traits, such as species-jumping ability.

  • BDL-3: Human virus characteristics, including transmissibility and vaccine resistance.

  • BDL-4: Enhanced human viruses with potentially higher contagion, subject to the strictest controls.

To ensure safe access, the letter recommends technical tools including watermarking datasets to track leaks, audit logs with tamper-proof signatures, data provenance tracking, and behavioural biometrics to verify legitimate users.

The authors emphasize that balancing openness with security will be essential as AI systems grow more powerful. Without clear rules, frontier developers are left to make subjective decisions about what constitutes risky data, creating potential gaps in biosecurity.

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Study finds thinking about certain alcoholic drinks can influence mood and mindset

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A new academic study suggests that simply thinking about different types of alcoholic drinks can influence a person’s mood and mindset, even when no alcohol is consumed.

The research, published in the journal Young Consumers, found that specific beverages tend to trigger distinct cultural associations in people’s minds. The findings indicate that drinks such as tequila, whiskey and wine are strongly linked to particular attitudes and emotional responses.

The study was conducted by a team of researchers led by Logan Pant, an assistant professor of marketing at University of Evansville in the United States.

Pant said the project aimed to understand how people mentally associate different alcoholic beverages with social themes and personality traits.

“We conducted two preliminary studies to understand how people think about different types of alcohol,” Pant told Associated Press. “In the first study, participants answered open-ended questions, and in the second they completed a word-association task.”

In total, the research involved four experiments with 429 participants. The early stages of the project helped researchers identify what they described as “learned associations,” or ideas that people develop through cultural exposure and personal experience.

Participants were asked to think about a randomly assigned drink and then rate how strongly they felt certain personality traits or emotional qualities. Importantly, the participants did not consume alcohol during the experiments, allowing researchers to examine psychological associations without the physical effects of drinking.

The study grouped responses into three main mindsets. The “party mindset” included terms such as energetic, outgoing, fun and celebratory. The “masculinity mindset” was linked with words such as strong, confident and tough. The “sophisticated mindset” included qualities like elegant, classy, refined and formal.

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Researchers found clear patterns in the results. Tequila was most frequently connected with celebration, excitement and social gatherings. Whiskey tended to be associated with masculinity, strength and confidence. Wine, on the other hand, was linked to sophistication, elegance and refinement.

Pant said the results suggest alcoholic drinks can act as symbolic cues that trigger particular psychological responses.

“These findings show that alcohol can function as a symbolic cue,” he said, noting that the attitudes people associate with certain drinks appear to come from cultural learning rather than intoxication.

Public health experts say the findings are important because they highlight how social expectations and cultural messages can shape attitudes toward alcohol, especially among younger generations.

Although many people consume alcohol for social or recreational reasons, excessive drinking can lead to health problems including Alcohol use disorder and an increased risk of several cancers.

Previous research has already shown that alcohol consumption can affect behaviour, making people more uninhibited or more likely to take risks. The new study focuses instead on how cultural cues linked to alcohol may influence thoughts and expectations before any drinking occurs.

Researchers say understanding these psychological associations could help inform public health campaigns aimed at promoting moderation and responsible drinking. Such efforts often encourage people to pace their drinks, stay hydrated and avoid excessive consumption.

Pant said future research could explore how these associations vary across cultures, age groups and social environments, and whether targeted interventions could help shift perceptions around alcohol toward safer behaviours.

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Spanish researchers develop corneal implants using discarded fish scales

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Scientists in Granada have developed experimental corneal implants made from fish scales, a discovery that could help address the global shortage of donor corneas used in eye transplants.

The research, led by scientists at the University of Granada, focuses on transforming scales from commonly consumed fish such as Common carp into transparent and durable implants capable of repairing damaged corneas. Early laboratory tests and animal studies have produced encouraging results, according to the research team.

The project has been carried out by specialists from the university’s Department of Histology, who have spent several years studying fish scales that are normally discarded as waste in seafood markets.

Researchers say the structure of fish scales makes them a promising material for biomedical use. After processing and treatment, the scales can be converted into a biocompatible implant that is transparent and strong enough to function as a replacement for the cornea.

The cornea is the clear outer layer at the front of the eye and plays a key role in focusing vision. When the cornea becomes severely damaged due to injury or disease, the only effective treatment in many cases is a corneal transplant using donated tissue.

However, specialists say donor corneas are in short supply around the world. Many patients spend months or years on waiting lists, while others never receive a transplant due to the limited availability of suitable donor tissue.

Scientists at the University of Granada believe the new technique could offer an alternative solution if further testing confirms its effectiveness.

The study has been funded by the Instituto de Salud Carlos III, which operates under Spain’s Ministry of Science, Innovation and Universities. The research is part of project PI23/00335, which aims to explore new biomaterials for medical treatments.

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The findings were presented in the presence of Manuel Reyes, manager of the Hospital Clínico San Cecilio in Granada. His participation highlights the growing interest from the medical community in the potential clinical use of the technology.

So far, the implants have successfully passed initial laboratory analysis and early tests in animals. These experiments were designed to confirm that the material is compatible with living tissue and capable of maintaining the structure required for a functioning cornea.

Despite the promising results, researchers caution that the technology is still in an early stage. Before the implants can be used in patients, the project must undergo extensive clinical trials in humans, a process that can take several years and requires strict regulatory approval.

For now, the study demonstrates that carp scales can be processed into a material that behaves similarly to a natural cornea at both structural and biological levels.

While the concept is not yet ready for use in operating rooms, scientists say the results represent an important step toward finding new ways to treat corneal damage in a field where donor shortages remain a major challenge.

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Lifelong Learning May Delay Alzheimer’s and Slow Cognitive Decline, Study Finds

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Keeping the brain active through learning and mentally engaging activities may help delay the onset of Alzheimer’s disease, according to a new study that highlights the benefits of lifelong intellectual stimulation.

Researchers found that people who frequently take part in activities such as reading, writing, learning new languages, playing strategy games, or visiting museums are less likely to develop dementia and may experience a slower decline in memory and thinking skills as they age.

The study was led by neuropsychologist Andrea Zammit of Rush University Medical Center in Chicago. Zammit said activities that challenge the mind help stimulate different areas of the brain and strengthen cognitive abilities.

“They kind of stretch your brain and your thinking. You’re using different cognitive systems,” she explained.

Experts say it is never too late to begin engaging in activities that stimulate the brain. Even people who did not regularly participate in intellectually challenging hobbies earlier in life can benefit from starting later. Researchers note that middle age may be a particularly important period for maintaining long-term brain health.

Scientists are exploring several ways people can stay mentally sharp, including learning to play musical instruments, birdwatching, or using brain-training games. According to Zammit, the key is not simply trying many activities briefly but finding meaningful interests and staying committed to them over time.

Health specialists also stress that mental activity is only one part of protecting brain health. Physical well-being plays a major role. Regular exercise, maintaining healthy blood pressure, good sleep habits, and vaccinations later in life are also recommended to support brain function.

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The research involved nearly 2,000 adults between the ages of 53 and 100 who did not have dementia when the study began. Participants were monitored for eight years while researchers assessed their involvement in educational and mentally stimulating activities during youth, middle age, and later life. They also completed neurological and memory tests throughout the study period.

During the research, some participants developed Alzheimer’s disease. However, those who reported the highest levels of intellectual activity throughout their lives experienced the onset of the disease roughly five years later than those who engaged in the least mental stimulation. The findings were published in the medical journal Neurology.

Researchers also examined brain autopsies from 948 participants who died during the study. Even when the brains showed signs associated with Alzheimer’s disease, people who had more intellectually active lifestyles maintained stronger memory and thinking abilities before death.

Scientists describe this protective effect as cognitive reserve. The concept suggests that learning strengthens networks in the brain, helping it adapt and function despite damage caused by ageing or disease.

Dementia continues to rise globally. According to Alzheimer’s Disease International, more than 57 million people worldwide live with dementia, with over 10 million new cases diagnosed each year. Researchers say simple activities that challenge the mind may play an important role in slowing the impact of the disease.

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