Health
New Study Links Obesity to Faster Progression of Alzheimer’s Disease
A new analysis presented in the United States suggests that routine blood tests could play a greater role in tracking Alzheimer’s disease, particularly among people living with obesity. The research, conducted by scientists at Washington University School of Medicine in St. Louis, indicates that obesity may accelerate the early biological changes associated with the condition.
The study, which will be shared at the annual meeting of the Radiological Society of North America, examined 407 adults over a five-year period. Participants underwent regular blood tests and PET scans, the latter measuring the buildup of amyloid plaques in the brain — a hallmark of Alzheimer’s disease. The blood tests assessed proteins and other biomarkers that are linked to cognitive decline.
Dr. Cyrus Raji, associate professor of radiology and neurology and one of the study’s authors, said this research marks the first time a clear relationship has been identified between obesity and Alzheimer’s progression using blood biomarker tests. He noted that blood results were able to detect obesity’s influence on Alzheimer’s-related changes more precisely than PET scans alone.
“The fact that we can track the predictive influence of obesity on rising blood biomarkers more sensitively than PET is what astonished me in this study,” Raji said.
According to the findings, people with obesity showed faster deterioration in several key biomarkers. The researchers reported a 24 per cent faster increase in the protein plasma NfL, which is associated with nerve damage. Levels of the blood biomarker plasma pTau217 rose 29 to 95 per cent faster in individuals with obesity, and amyloid plaque accumulation increased by 3.7 per cent.
Raji said these results may give doctors new ways to monitor how Alzheimer’s develops, especially as new treatments targeting amyloid buildup become more common. By using both blood tests and imaging, doctors may be able to gain a clearer picture of how the disease responds to medication.
“It’s marvellous that we have these blood biomarkers to track the molecular pathology of Alzheimer’s disease, and MRI scans to track additional evidence of brain degeneration and response to various treatments,” he noted.
Obesity has long been recognised as a risk factor for dementia. Individuals with obesity are more likely to experience conditions such as high blood pressure, type 2 diabetes, and reduced physical activity, all of which heighten the risk of cognitive decline.
Globally, around 57 million people are living with dementia, according to the World Health Organization. Alzheimer’s disease represents the largest share, accounting for between 60 and 70 per cent of all cases.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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