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New Review Finds No Clear Evidence That Ketamine Eases Chronic Pain

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A major scientific review has cast doubt on the use of ketamine as a treatment for chronic pain, warning that current evidence is too weak to support its effectiveness.

Once known largely as a party drug, ketamine has in recent years been repurposed in wellness and medical circles, with clinics across Europe offering it as a potential remedy for depression and long-lasting pain. The anaesthetic has a long history in hospitals, where it is used to sedate patients during surgery and as an emergency painkiller. But despite the growing interest, researchers say its benefits for chronic conditions remain unproven.

The review, conducted by Cochrane, an independent nonprofit research organisation, analysed data from 67 clinical trials involving more than 2,300 participants. The trials tested five drugs that target the N-methyl-D-aspartate (NMDA) receptor, which influences how pain signals are processed in the brain. Alongside ketamine, the review included memantine, dextromethorphan, amantadine, and magnesium.

According to the findings, none of the drugs showed clear or consistent benefits for treating chronic pain conditions such as diabetic nerve pain, fibromyalgia, post-shingles pain, or complex regional pain syndrome.

“We want to be clear – we’re not saying ketamine is ineffective, but there’s a lot of uncertainty,” said Michael Ferraro, one of the study’s authors and a researcher at the University of New South Wales. “The data could point to a benefit or no effect at all. Right now, we just don’t know.”

The analysis also highlighted the risks of ketamine, especially when administered intravenously. Reported side effects included delusions, paranoia, delirium, nausea, and vomiting, which were described as “distressing for many patients.”

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Importantly, the review did not examine ketamine’s role in treating depression or its potential as a replacement for opioid painkillers. Researchers warned, however, against extending ketamine’s established short-term use in emergency settings to long-term management of chronic conditions.

“We’ve seen the harm that can come from taking medicines developed for acute pain and applying them to chronic pain – opioids are a prime example,” said James McAuley, a professor at UNSW and co-author of the study. “Now we’re seeing a similar pattern with ketamine. We need to be careful not to rush into widespread use without strong evidence.”

The findings arrive amid a surge of interest in new pain treatments, as doctors and patients seek alternatives to opioids. But for now, the researchers conclude, there is little reliable data to support ketamine as a solution for chronic pain – and more rigorous studies are urgently needed.

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Europe Faces Persistent Doctor Shortages Despite Rising Graduate Numbers

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Doctor shortages continue to challenge healthcare systems across Europe, driven by an ageing workforce and a declining interest among graduates in general practice.

Every year, thousands of students complete their medical studies in Europe, yet the region still struggles to meet demand for healthcare professionals. In 2023, over 66,000 doctors graduated in the European Union, equivalent to roughly 15 graduates per 100,000 inhabitants, according to Eurostat. Numbers vary widely between countries, with Türkiye producing 13,720 graduates, Germany 10,186, and Italy 9,795. At the other end of the spectrum, only 31 doctors completed their studies in Montenegro, 52 in Iceland, and 144 in Estonia.

A significant share of graduates in countries such as Bulgaria, Romania, and Latvia are foreign nationals, many of whom leave the country after completing their studies. This has turned some nations into training hubs for doctors while widening regional disparities. Romania, however, has managed to reduce doctor migration over the past decade. According to the World Health Organization (WHO), the number of doctors leaving Romania fell from 1,500 in 2012 to 461 in 2021, thanks to improved pay, training, and working conditions.

“Health worker migration is a reality in our interconnected and globalised world, and we have the solutions to ensure it works for all parties. Countries can learn from each other’s experiences,” said Natasha Azzopardi-Muscat of WHO Europe. She added that failing to manage workforce movement fairly risks worsening health inequities and leaving fragile healthcare systems unable to cope.

Despite more graduates entering the system, shortages remain acute, particularly among general practitioners (GPs). While the overall number of doctors has grown in most countries, only about one in five in the EU work as GPs. Tiago Villanueva, a family physician and president of the European Union of General Practitioners/Family Physicians, told Euronews Health that graduates increasingly choose specialised fields, such as dermatology or ophthalmology, for better work-life balance and quality of life. He added that the solution lies in making general practice more visible and appealing, rather than simply increasing the number of medical graduates.

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Europe’s doctor shortages are unevenly distributed. Austria has the highest ratio of practising doctors at 551 per 100,000 inhabitants, followed by Italy and Cyprus at 535, while Finland has the lowest at 288 per 100,000.

Ageing of the healthcare workforce adds further pressure. In 2023, nearly one-third of doctors in EU countries were over 55, according to OECD data. Countries with large shares of older doctors will need to train sufficient numbers of new professionals while encouraging those nearing retirement to continue working where possible.

With a projected shortage of 950,000 health workers by 2030, Europe faces a critical challenge in balancing rising graduate numbers with the need to retain talent and fill vital roles in general practice and other essential specialties.

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Universal School Meals Could Reduce Global Undernourishment by Nearly a Quarter, Study Finds

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Providing every child with a healthy, sustainable school meal could significantly cut global hunger, prevent diet-related deaths, and reduce the environmental impact of diets, according to new research by University College London (UCL).

Scientists estimate that extending school meal coverage from the current level of about one in five children to all children worldwide by 2030 could reduce the overall prevalence of undernourishment by around 24 percent. The modelling study suggests such an approach could also prevent more than one million deaths each year from diet-related diseases and cut the number of people lacking essential vitamins by roughly 120 million.

“Our modelling shows that healthy and sustainable school meals can generate substantial health and environmental gains in every region of the world,” said Marco Springmann, the corresponding author of the study and modelling lead for the Research Consortium at UCL’s Institute for Global Health. “The evidence is clear: investing in school meals is both effective and economically sound.”

The study compared current school meal coverage with a scenario in which all children receive at least one meal a day. Researchers examined the potential effects on nutrition, long-term health, greenhouse gas emissions, land and water use, and calculated the cost savings from improved health outcomes and reduced environmental damage.

Results show that environmental benefits depend on meal composition. School meals aligned with healthy and sustainable dietary recommendations—emphasizing vegetables and limiting meat and dairy—combined with reduced food waste, could cut food-related environmental impacts by roughly half. The study also examined costs, estimating additional spending equivalent to about 0.1 percent of national income in high-income countries and up to 1 percent in low-income nations. However, reductions in healthcare costs and climate-related damages were found to largely offset these investments.

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Currently, school meal programs feed approximately 466 million children every day, representing around 70 percent of the global public food system. Experts warn that achieving universal coverage will require strong political commitment and consistent funding, especially in low-income countries, where fewer than one in ten children receive school meals.

“School meals are not just a nutrition programme – they are a powerful lever for transforming food systems,” said Silvia Pastorino, diets and planetary health lead for the Research Consortium for School Health and Nutrition and a researcher at the London School of Hygiene & Tropical Medicine. “When meals are healthy, sustainable and linked to food education, they improve children’s wellbeing today and foster long-term sustainable habits, while helping countries protect biodiversity, reduce emissions and build resilient communities.”

The research consortium is part of the School Meals Coalition, an initiative led by France and Finland, formed in 2021 after more than 100 countries pledged to provide a healthy school meal for every child by 2030. The consortium is also developing a “Planet-Friendly School Meals Toolkit” to help countries evaluate costs, health benefits, and environmental impacts of sustainable school meal programs, with first results expected in spring 2026.

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From Functional Drinks to LED Masks: The Biggest Health Trends of 2025 and What Experts Say

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As 2025 comes to a close, social media continues to shape the way people eat, drink, rest, and optimise their health, with platforms like TikTok, Instagram, and Reddit driving a mix of revived and new wellness trends. Some have gone viral for their novelty, while others raise questions about effectiveness and safety.

One of the most visible trends has been “loaded water” or “enhanced water,” which combines plain water with electrolytes, flavourings, supplements, coconut water, or fruit. Proponents claim it boosts energy, digestion, and focus. Nutrition experts caution that most people do not need daily electrolyte supplements, as the body regulates these naturally. “Excessive intake of some electrolytes, such as sodium and potassium, may be risky for people with high blood pressure or kidney disease,” dietitian Helen Tieu told Healthline. She recommends using whole fruit over syrups or powders and keeping sugar content low.

Diet trends such as the carnivore and “lion” diets, which limit consumption to meat, eggs, dairy, or in the lion diet, just beef, salt, and water, have also gained attention. Advocates claim these diets improve gut health, sleep, and skin, but experts warn of significant risks. Dr Bhavini Shah from LloydsPharmacy Online Doctor described the carnivore diet as unbalanced, noting overconsumption of meat is linked to high blood pressure, cholesterol, cardiovascular disease, and Type-2 diabetes. Research from Harvard and MIT found processed red meat accelerated cognitive ageing by 1.6 years per average serving, while substituting nuts or legumes lowered dementia risk.

In skincare, at-home LED masks have become a popular tool, offering red, blue, or near-infrared light therapy. Consultant dermatologist Dr Jonathan Kentley said the technology can trigger collagen production and reduce acne, while Dr Justine Kluk warned that benefits remain modest and long-term studies are limited. Dermatologist Janiene Luke added that at-home masks are not as effective as clinical treatments but can complement prescription regimens.

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Functional drinks, including mushroom coffees and CBD-infused beverages, also went mainstream, with ingredients like ashwagandha, Lion’s Mane, magnesium, and L-theanine marketed for stress relief, focus, and calm. Nicole Cucco, a registered dietitian, said some evidence supports these ingredients, particularly for stress or attention, but effects often depend on individual deficiencies or placebo influence. She urged consumers to research products carefully rather than rely solely on marketing claims.

Other viral wellness habits, such as “bed rotting” — spending extended periods resting or sleeping as a form of self-care — reflect a broader trend toward mental health and downtime. Experts note these practices can be beneficial if balanced with activity, but they are no substitute for medical guidance or structured routines.

As 2025 ends, it is clear that health trends online can be fun and sometimes helpful, but experts emphasize that evidence and moderation remain essential when adopting new wellness practices.

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