Health
Stanford Study Links Epstein-Barr Virus to Lupus, Revealing Hidden Trigger Behind Autoimmune Disease
New research from Stanford University links the Epstein-Barr virus (EBV) to lupus disease, showing how the virus can push immune cells to attack the body’s own tissues. The findings, published this week in Science Translational Medicine, suggest that the common childhood virus may be the key trigger behind lupus, a chronic autoimmune disorder that affects millions worldwide.
According to the study, EBV — a virus carried by more than 90 percent of adults — appears to manipulate the body’s immune cells in a way that sparks lupus. “This is the single most impactful finding to emerge from my lab in my entire career,” said Dr. William Robinson, professor of immunology and rheumatology at Stanford University and the study’s senior author. “We think it applies to 100 per cent of lupus cases.”
Lupus occurs when the immune system mistakenly attacks healthy tissues, leading to inflammation that can damage the skin, joints, kidneys, heart, and nervous system. The disease affects women far more than men, accounting for roughly 90 percent of cases. While medications such as ibuprofen can manage symptoms, about 5 percent of patients develop life-threatening complications. There is currently no cure.
Epstein-Barr virus is best known for causing mononucleosis, or “mono,” often called the “kissing disease.” Most people contract it during childhood or adolescence through saliva, such as by sharing food, drinks, or through kissing. “Practically the only way to not get EBV is to live in a bubble,” Robinson said, noting that the odds of exposure are nearly 20 to 1.
Once inside the body, EBV hides within B cells — immune cells responsible for making antibodies to fight infection. The virus can hijack these cells, turning them rogue and prompting them to attack the body’s own tissues. Researchers found that in lupus patients, EBV-infected B cells are about 25 times more common than in healthy individuals.
The virus produces a protein known as EBNA2, which activates human genes linked to inflammation. This triggers an immune chain reaction where B cells stimulate other immune cells to attack cell nuclei, a hallmark of lupus. When enough of these overactive cells accumulate, a full autoimmune response develops.
The study also suggests that the same viral mechanism may contribute to other autoimmune conditions such as multiple sclerosis, rheumatoid arthritis, and Crohn’s disease. Researchers believe that genetics, variations in viral strains, and environmental factors may determine why some individuals develop autoimmune disorders after infection.
Several biotechnology firms are developing vaccines to prevent EBV infection, with early-stage clinical trials already underway. However, experts say such vaccines would only be effective if administered before initial exposure — meaning protection would need to start early in life.
If confirmed, Stanford’s discovery could reshape the understanding of autoimmune diseases and pave the way for preventive strategies against one of the world’s most persistent viruses.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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