Health
New Research Links Ultra-Processed Foods to Higher Risk of Cancer-Related Polyps in Women
Women who ate the most ultra-processed foods had a higher risk of developing polyps that can lead to cancer compared with women who ate the least. That finding sits at the centre of a new study that is drawing attention to how shifts in modern eating habits may be shaping health outcomes. Scientists have pinpointed a potential driver of the global rise in colon and rectal cancers among young people: ultra-processed foods.
These foods, which include packaged snacks, mass-produced breads, sweetened breakfast cereals, instant noodles and frozen pizzas, have become a significant part of daily diets in recent decades. During that time, doctors have reported a noticeable rise in colorectal cancers diagnosed before age 50. “When a couple gets divorced, everyone in their orbit is affected—not just the two people whose ‘I do’ turned into ‘I don’t.’ And boy, does that crowd have something to say about it. Some people are so shocked that they can’t restrain their nosiness. Others fear divorce is contagious and will happen to them.” Researchers say the same ripple effect can be seen in public health: as eating patterns shift, the wider population may feel the impact in unexpected ways.
In the latest research, results were drawn from more than 29,000 U.S. women whose diets and endoscopy records were tracked across two decades. By reviewing long-term data, scientists were able to compare the health outcomes of women who consumed high levels of ultra-processed foods with those who ate far less.
The study showed that women with the highest intake faced a 45 percent greater risk of developing adenomas — growths or polyps in the colon and rectum that can become cancerous — than women with the lowest intake. Most polyps are harmless, but some can progress into cancer over several years.
“The increased risk seems to be fairly linear, meaning that the more ultra-processed foods you eat, the more potential that it could lead to colon polyps,” said Dr. Andrew Chan, a gastroenterologist at the Mass General Brigham Cancer Institute and one of the study’s authors. He added that reducing consumption of these foods, often high in sugar, salt, saturated fat and additives, could help “mitigate the rising burden of early-onset colorectal cancer.”
Researchers noted that ultra-processed food intake did not appear to influence the risk of serrated lesions, another type of precursor to colorectal cancer. The pattern held even when other known risk factors such as obesity and low fibre intake were considered.
Published in JAMA Oncology, the study stops short of proving that ultra-processed foods directly cause cancer. Scientists say more work is needed to understand which types of ultra-processed foods may pose the greatest harm and what other factors could be driving the rise in early-onset colorectal cancer. Many women in the study consumed most of their ultra-processed food through breads, breakfast items, sauces, spreads and sweetened beverages.
“Diet isn’t a complete explanation for why we’re seeing this trend — we see many individuals in our clinic with early onset colon cancer who eat very healthy diets,” Chan said.
Health
Study Finds Men Far More Likely Than Women to ‘Hit the Wall’ in Marathons
Health
Study Links Higher Coffee Consumption to Lower Risk of Liver Disease
Regular coffee consumption may help reduce the risk of serious liver diseases, including cirrhosis, liver cancer and liver-related deaths, according to a new study published in the journal Clinical Gastroenterology and Hepatology.
The research found that people who consumed higher amounts of coffee, including decaffeinated varieties, were less likely to develop chronic liver conditions than those who drank little or no coffee. The findings add to growing evidence that coffee may play a role in supporting long-term liver health, although researchers stressed that the results do not prove a direct cause-and-effect relationship.
The study examined data from more than 350,000 participants enrolled in the UK Biobank, one of the world’s largest long-term health research projects. None of the participants had cirrhosis or liver cancer at the beginning of the study. Researchers monitored their health over a period of 13 years to assess how coffee consumption affected liver-related outcomes.
According to the findings, participants who drank five or more cups of coffee each day had a 32 percent lower risk of developing cirrhosis than those who consumed little or no coffee. They also recorded a 47 percent lower risk of liver cancer and a 42 percent reduction in deaths linked to liver disease.
Researchers found additional indicators of improved liver health among regular coffee drinkers. Participants with higher coffee intake showed lower levels of liver fat, liver iron, fibrosis and inflammation. Blood tests also revealed increased levels of proteins associated with healthy liver function, while markers linked to liver scarring and inflammation were generally lower.
The findings come as liver disease continues to pose a major global health challenge. A separate study published in 2023 estimated that liver disease causes around two million deaths each year, accounting for about four percent of all deaths worldwide. Men account for nearly two-thirds of those fatalities.
Despite the encouraging results, the researchers urged caution in interpreting the findings. Senior study author Ju Dong Yang said moderate coffee consumption appears to be beneficial for people who already enjoy drinking coffee and tolerate it well.
“Our findings support moderate coffee consumption for people who already enjoy and tolerate it well,” Yang said.
He added that the study does not provide sufficient evidence to recommend that people who do not currently drink coffee should begin doing so solely to reduce their risk of liver disease.
Health experts continue to advise that maintaining a healthy weight, limiting alcohol consumption, eating a balanced diet and managing conditions such as obesity and diabetes remain the most effective ways to reduce the risk of chronic liver disease. Researchers said additional studies are needed to better understand which compounds in coffee may contribute to its potential protective effects.
Health
Lancet Review Finds mRNA Vaccines Safe and Highly Effective, Calls for Wider Global Access
A comprehensive review of data covering billions of administered doses of mRNA vaccines has concluded that the technology remains both safe and highly effective in preventing infectious diseases, with researchers urging governments and health organisations to focus on expanding global access.
The review, published in The Lancet, examined evidence gathered since mRNA vaccines were first deployed on a large scale during the COVID-19 pandemic. Researchers found that the vaccines continue to provide strong protection against severe illness while serious side effects remain uncommon.
Unlike conventional vaccines, mRNA vaccines work by delivering genetic instructions that enable the body’s cells to produce a harmless viral protein. This process trains the immune system to recognise and respond to future infections without altering a person’s DNA.
According to the review, mRNA vaccines were 87% effective in preventing confirmed SARS-CoV-2 infections within 14 to 42 days after vaccination. The vaccines also demonstrated 93% effectiveness in preventing hospital admissions and 94% effectiveness in preventing deaths related to COVID-19 during the same period.
Researchers noted that immunity declines over time, but booster doses restore a significant portion of the lost protection.
The review also assessed vaccine safety across billions of administered doses. It found that serious adverse events, including myocarditis, pericarditis and anaphylaxis, occurred very rarely. Most reported reactions, such as pain at the injection site, fatigue and fever, were mild to moderate and typically resolved within a few days.
“Across billions of administered doses, serious adverse events have been rare, well characterised, and consistently outweighed by the substantial protection conferred against severe disease, hospitalisation, and death,” the researchers wrote.
The review concluded that the vaccines have proven effective across a broad range of populations, including children, older adults, pregnant women and people with weakened immune systems.
Researchers also highlighted the growing potential of mRNA technology beyond infectious diseases. They said ongoing research could lead to personalised cancer vaccines designed to match an individual patient’s tumour characteristics, opening new possibilities for targeted treatment.
Co-author Manish Sadarangani of the University of British Columbia and BC Children’s Hospital Research Institute said mRNA vaccines have already changed how the world responds to emerging infectious diseases and could continue to play an important role in preventive medicine and cancer care.
The review also noted that improvements in vaccine storage, including higher-temperature storage methods and freeze-drying technologies, could simplify transportation, reduce waste and improve access in remote regions.
Despite these advances, the researchers stressed that manufacturing capacity and equitable distribution remain major challenges. They called for greater investment in local production, technology transfer and stronger regulatory systems, particularly in low- and middle-income countries.
Co-author Robin Shattock of Imperial College London said expanding manufacturing networks and strengthening regional production capabilities would shorten supply chains, lower costs and help ensure countries have faster access to vaccines during future global health emergencies.
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