Health
Scientists Explore New Frontiers in Autoimmune Disease Research as Cases Rise Worldwide
Scientists are still investigating potential causes and treatments for autoimmune conditions. Here’s what to know. Autoimmune diseases, which occur when the body’s defense system mistakenly attacks its own cells, now affect tens of millions of people globally. These conditions can strike nearly any part of the body and are most common among women, though men and children are not exempt. Rates have been climbing for years, raising urgent questions about how the immune system goes awry and how to better diagnose and treat these illnesses.
Researchers say progress in understanding the immune system is opening doors to new therapies that may go beyond controlling symptoms. “This is probably the most exciting time that we’ve ever had to be in autoimmunity,” said Dr Amit Saxena, a rheumatologist at NYU Langone Health in the United States. His optimism reflects a growing scientific push to reprogramme faulty immune responses rather than only suppress them.
Scientists have pinpointed a potential driver of the global rise in colon and rectal cancers among young people: ultra-processed foods. Women who ate the most ultra-processed foods had a higher risk of developing polyps that can lead to cancer compared with women who ate the least. The finding adds urgency to research into immune-related disorders, many of which appear to be influenced by environmental triggers.
More than 100 autoimmune diseases have been identified. Rheumatoid arthritis and psoriatic arthritis inflame joints. Sjögren’s disease is known for dry eyes and mouth. Myositis and myasthenia gravis weaken muscles, while lupus can attack organs ranging from the kidneys to the heart. Symptoms often ebb and flow unpredictably, with patients experiencing long periods of stability before suddenly facing a flare.
Diagnosing these conditions is notoriously difficult. Early signs are often vague, overlap with other illnesses, or appear sporadically. Doctors may order blood tests to search for misplaced antibodies, yet many patients spend years seeking answers from multiple specialists. Efforts to speed diagnoses are underway, including updated guidance for detecting multiple sclerosis.
Scientists are also studying how the immune system becomes confused. Normally, it distinguishes foreign threats from the body’s own tissues. When that tolerance breaks down, chronic disease can develop. Genetics can increase vulnerability, but usually an external trigger — infection, smoking, pollutants — is needed to set the process in motion. New evidence links the Epstein-Barr virus not only to multiple sclerosis but also to lupus, offering fresh insight into how hidden viral infections may spark long-term immune disruption.
Women face the highest risk of autoimmune disease, possibly due to hormonal influences or differences linked to the X chromosome. Some conditions, however, overwhelmingly affect men. VEXAS syndrome, discovered in 2020, typically strikes men over 50 with severe symptoms that include breathing problems and blood clots.
Treating autoimmune diseases remains complex. The global market for therapies exceeds $100 billion (€87 billion) annually, yet many patients still navigate trial-and-error treatment plans. While high-dose steroids and broad immune-suppressing drugs were once the main options, newer treatments now target specific molecules. The most promising new approach involves CAR-T therapy — originally developed for cancer — which wipes out malfunctioning immune cells and allows healthier ones to grow back. Early trials show potential benefits for lupus, myositis, and other conditions.
Scientists hope that continued research will bring earlier detection, better tools to prevent disease onset, and therapies that address root causes rather than symptoms.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
North African Dust Set to Worsen Air Quality Across Portugal
Health
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