Health
UK Scientists Uncover Breakthrough in Asthma and COPD Treatment
A new treatment approach for asthma and chronic obstructive pulmonary disease (COPD) has been identified by scientists in the UK, marking what is being hailed as the first major advancement in managing these conditions in half a century.
The findings, published in The Lancet Respiratory Medicine, reveal that a single injection of benralizumab, a monoclonal antibody, is significantly more effective than traditional steroid tablets in reducing symptom flare-ups, known as eosinophilic exacerbations. These episodes account for roughly 50% of asthma attacks and 30% of COPD attacks, causing symptoms such as wheezing, coughing, and chest tightness.
A New Approach to Inflammation
Steroid tablets, the conventional treatment, work by reducing inflammation in the lungs but are not effective for all patients and can lead to serious long-term side effects like high blood pressure and osteoporosis. In contrast, benralizumab targets white blood cells to reduce lung inflammation, curbing symptoms and lowering the need for additional treatments by 30%, according to the study.
“This could be a game-changer for people with asthma and COPD,” said Dr. Mona Bafadhel, lead investigator and chair of respiratory medicine at King’s College London.
Widespread Impact
COPD affects an estimated 36.6 million Europeans, while nearly 10 million people under 45 have asthma. These conditions significantly impact patients’ quality of life, particularly older individuals with both diseases, who often face limited life expectancies.
“We need to provide these patients with life-saving options before their time runs out,” said Dr. Sanjay Ramakrishnan, a study author and clinical senior lecturer at the University of Western Australia. He criticized current treatments as being “stuck in the 20th century.”
Trial Highlights
The study divided high-risk asthma and COPD patients into three groups: one received benralizumab, another steroids, and the third both treatments.
After 28 days, those treated with benralizumab showed better respiratory outcomes. At the 90-day mark, 74% of steroid-treated patients required further medical intervention due to treatment failure, compared to only 45% of those who received the antibody injection.
The findings suggest that a single benralizumab injection could become a vital emergency treatment, reducing hospital readmissions for asthma and COPD patients.
A Pivotal Moment in Respiratory Care
“We hope these pivotal studies will change how asthma and COPD exacerbations are treated for the future, ultimately improving the health for over a billion people living with asthma and COPD across the world,” Bafadhel stated.
The trial, supported by AstraZeneca and the University of Oxford, offers renewed hope for better management of respiratory diseases, potentially transforming care for millions globally.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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