Health
Fresh Embryos May Boost IVF Success for Women with Lower Fertility Odds, Study Finds
Women struggling with infertility and facing lower odds of success with in vitro fertilization (IVF) may have better chances of conceiving with fresh embryos rather than frozen ones, according to a new study from China.
The research, published in the BMJ, examined 838 women in their 30s who had a limited number of healthy eggs. It found that 40.1% of women who received fresh embryo transfers gave birth, compared to 31.5% of those who received frozen embryo transfers. Additionally, women who had fresh embryo transfers were more likely to get pregnant and less likely to suffer a miscarriage.
Rethinking the ‘Freeze-All’ Strategy
IVF, the most common fertility treatment worldwide, involves removing a woman’s eggs, fertilizing them with sperm in a lab, and transferring the resulting embryos back into the uterus. Many fertility doctors follow a “freeze-all” approach, where multiple embryos are collected and frozen for later use. This method is widely used to reduce potential risks associated with hormone stimulation and to allow the woman’s body to recover before implantation.
However, the new findings suggest that this strategy may not be the best option for women who already have lower chances of success. Factors such as age, underlying health conditions, low egg count, and poor egg quality all play a role in IVF outcomes, and fresh embryo transfers may improve results for these patients.
“A Crucial Clinical Question”
Dr. Daimin Wei, the study’s lead author and a professor at Shandong University’s Reproductive Medical Center, emphasized the significance of the findings.
“How to optimally use the ‘precious’ embryos to increase the chance of live birth in these patients is an important clinical question,” Wei told Euronews Health.
The study also found no difference in birth weight, neonatal health issues, or pregnancy complications between babies born from fresh or frozen embryos, further supporting the case for fresh transfers in specific patient groups.
Limitations and Future Research
This research is among the first to examine whether fresh or frozen embryos impact success rates in women with a poor prognosis. Most previous studies focused on women with normal or high chances of success, where frozen embryo transfers were found to be equally effective or even preferred.
The researchers acknowledged some limitations in their study, including differences in the number of embryos transferred and the developmental stage at which they were implanted. These factors could have contributed to the varying success rates between fresh and frozen transfers.
Additionally, male fertility and sperm quality were noted as contributing factors in about 17% of cases, reinforcing the need for a holistic approach to fertility treatments.
A More Personalized Approach to IVF
While fresh embryo transfers may not be the best option for all IVF patients, the study suggests that fertility doctors should consider individual patient characteristics when planning treatments.
“For clinicians, it is suggested to individually choose the embryo transfer strategy based on ovarian response and patient characteristics to optimize IVF outcomes,” Wei concluded.
The findings could help refine IVF protocols, offering more personalized fertility treatments and potentially improving success rates for those facing the greatest challenges in conceiving.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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