Connect with us

Health

Men’s Brains Shrink Faster with Age, But Alzheimer’s Still Strikes Women More Often, Study Finds

Published

on

Men experience faster brain shrinkage as they age than women, yet Alzheimer’s disease remains nearly twice as common in women, according to a new study that challenges long-held assumptions about the roots of the gender gap in dementia.

The research, published this week in the Proceedings of the National Academy of Sciences (PNAS), examined more than 12,000 brain scans from nearly 5,000 healthy individuals aged 17 to 95. The findings show that while men’s brains show a steeper rate of decline across several key regions, this does not explain why women are far more likely to develop Alzheimer’s disease.

According to the World Health Organization (WHO), around 57 million people were living with dementia in 2021, with nearly 10 million new cases recorded annually. Alzheimer’s disease — the most common form of dementia — disproportionately affects women, with one in five developing the disease by age 45, compared to one in ten men.

For decades, scientists have sought to determine whether structural differences in how male and female brains age could explain this disparity. However, the new study suggests otherwise.

Researchers found that men’s brains tend to shrink faster in multiple regions linked to memory, sensory processing, and movement. The postcentral cortex — the part of the brain that processes sensations such as touch and pain — declined by 2% per year in men, compared to 1.2% in women. Men also exhibited greater thinning in the cerebral cortex, particularly in regions tied to memory and visual recognition, such as the parahippocampal and fusiform areas.

Additionally, men showed more pronounced decline in subcortical structures including the putamen and caudate, which are critical for movement control. Women, by contrast, showed more fluid accumulation in the brain’s ventricles — a sign of normal ageing — but retained more structural integrity overall.

Despite this, women continue to face a far higher risk of Alzheimer’s disease. Experts say the reasons lie beyond structural brain changes, pointing instead to hormonal, genetic, and lifespan factors.

“Hormonal changes after menopause, vascular and immune differences, and genes like APOE ε4 all play a role,” said one of the study’s authors. “Women also live longer than men, which naturally increases their risk.”

Globally, women’s life expectancy is about five years longer than men’s — 73.8 years versus 68.4 years in 2021 — meaning more women live into the age range where Alzheimer’s risk is highest.

The findings underscore the complexity of Alzheimer’s and the need to explore biological and environmental factors beyond simple brain volume loss. As the researchers concluded, the key to understanding women’s greater vulnerability to dementia “will not be found in brain scans alone.”

Health

WHO Warns of Sharp Rise in Mental Health Conditions Among Europe’s Youth

Published

on

A growing number of children and teenagers across Europe are experiencing mental health conditions, with global health officials warning that support systems are failing to keep pace with the surge. A new analysis released by the World Health Organization (WHO) outlines the scale of the challenge and calls for urgent action across the region.

According to the report, one in seven Europeans under the age of 20 are living with a mental health condition — a rise of about one-third over the past 15 years. The findings show clear gender disparities, with girls facing greater vulnerability. Among girls aged 15 to 19, one in four report having a mental health condition, making them the most affected group.

The report also highlights striking differences between countries. Teenagers in the Faroe Islands, Iceland and Denmark ranked among the highest for mental wellbeing, while those in Ukraine, Cyprus and Poland were placed at the lower end of the scale. The data reflects both long-term trends and the impact of recent crises.

Concerns about youth mental health have intensified in recent years, driven by a combination of social isolation, the effects of the COVID-19 pandemic, geopolitical tensions and growing economic pressures. Experts say these factors have created an environment in which young people are increasingly exposed to stress and uncertainty.

Access to professional support remains one of the region’s biggest obstacles. The WHO report notes that about one-quarter of European countries do not have community-based mental health services for young people. In addition, one in five countries lack dedicated mental health policies, leaving many children and teenagers without structured pathways to receive help.

“This report is a wake-up call,” said Dr. João Breda, who works on patient safety and healthcare quality at the WHO. “Every child and young person has the right to mental health support and high-quality care.”

The findings mark the first time the WHO has compiled extensive data on child and youth mental health across its European region, which includes 53 countries in Europe and Central Asia. The report stresses the need for stronger in-person care, noting rising concerns about young people turning to digital tools for emotional support. The document raises alarms about cases in which reliance on artificial intelligence chatbots, including ChatGPT, has led to harmful outcomes.

The WHO is urging governments to strengthen their mental health frameworks by increasing investment, expanding services and updating programmes to better reflect the needs of children and adolescents.

“By acting now, countries can build resilient systems that help the next generations thrive,” Breda said.

Continue Reading

Health

Poliovirus Detected in Hamburg Wastewater, Raising Public Health Alerts

Published

on

Health authorities in Germany have discovered traces of the poliovirus in sewage from Hamburg, highlighting a persistent health threat decades after Europe was declared polio-free. The finding has prompted renewed calls for enhanced disease monitoring and vaccination coverage.

Germany has not reported any confirmed cases of poliomyelitis, a highly contagious disease that primarily affects young children and can invade the nervous system, sometimes causing paralysis. The poliovirus detected in Hamburg’s wastewater is genetically similar to a strain last identified in Afghanistan, one of only two countries where polio remains endemic.

The European Centre for Disease Prevention and Control (ECDC) described the detection as “unusual, but not unexpected.” Germany’s last known locally transmitted polio case occurred in 1990, and the continent was officially declared polio-free in 2002. However, health officials caution that imported cases remain possible, particularly among populations with low vaccination coverage.

The World Health Organization (WHO) emphasized that the discovery underscores the ongoing risk: “Until polio is eradicated everywhere, all countries remain at risk of importation of the virus and potential re-infection.” Poliovirus can appear in sewage when individuals shed the virus in their stool. This does not necessarily indicate illness, as it can also result from people receiving the oral polio vaccine, which contains a weakened live virus.

Last year, similar detections in Germany, Poland, and Spain prompted health authorities to urge countries to strengthen surveillance systems and vaccination campaigns to protect populations from potential outbreaks. Across the European Union, vaccination coverage among one-year-olds ranged from 79 percent in Romania to 99 percent in Hungary and Luxembourg, according to WHO data. Experts note that gaps may persist at the local level, leaving some communities vulnerable to transmission.

Despite the presence of the virus in sewage, the ECDC stressed that the overall risk to the European population remains “very low.” Health authorities are using the findings to monitor trends and reinforce vaccination messaging, particularly in areas where immunization rates fall below recommended levels.

Germany’s recent detection serves as a reminder that polio, although rare in Europe, has not been fully eliminated globally. Public health officials continue to advocate for robust immunization programs, vigilant disease surveillance, and rapid response plans to prevent the virus from spreading should a case arise.

The Hamburg wastewater discovery has renewed focus on the importance of vaccination and monitoring, reinforcing global efforts to ensure that polio remains under control until it is eradicated worldwide.

Continue Reading

Health

Scientists Explore New Frontiers in Autoimmune Disease Research as Cases Rise Worldwide

Published

on

Scientists are still investigating potential causes and treatments for autoimmune conditions. Here’s what to know. Autoimmune diseases, which occur when the body’s defense system mistakenly attacks its own cells, now affect tens of millions of people globally. These conditions can strike nearly any part of the body and are most common among women, though men and children are not exempt. Rates have been climbing for years, raising urgent questions about how the immune system goes awry and how to better diagnose and treat these illnesses.

Researchers say progress in understanding the immune system is opening doors to new therapies that may go beyond controlling symptoms. “This is probably the most exciting time that we’ve ever had to be in autoimmunity,” said Dr Amit Saxena, a rheumatologist at NYU Langone Health in the United States. His optimism reflects a growing scientific push to reprogramme faulty immune responses rather than only suppress them.

Scientists have pinpointed a potential driver of the global rise in colon and rectal cancers among young people: ultra-processed foods. Women who ate the most ultra-processed foods had a higher risk of developing polyps that can lead to cancer compared with women who ate the least. The finding adds urgency to research into immune-related disorders, many of which appear to be influenced by environmental triggers.

More than 100 autoimmune diseases have been identified. Rheumatoid arthritis and psoriatic arthritis inflame joints. Sjögren’s disease is known for dry eyes and mouth. Myositis and myasthenia gravis weaken muscles, while lupus can attack organs ranging from the kidneys to the heart. Symptoms often ebb and flow unpredictably, with patients experiencing long periods of stability before suddenly facing a flare.

Diagnosing these conditions is notoriously difficult. Early signs are often vague, overlap with other illnesses, or appear sporadically. Doctors may order blood tests to search for misplaced antibodies, yet many patients spend years seeking answers from multiple specialists. Efforts to speed diagnoses are underway, including updated guidance for detecting multiple sclerosis.

Scientists are also studying how the immune system becomes confused. Normally, it distinguishes foreign threats from the body’s own tissues. When that tolerance breaks down, chronic disease can develop. Genetics can increase vulnerability, but usually an external trigger — infection, smoking, pollutants — is needed to set the process in motion. New evidence links the Epstein-Barr virus not only to multiple sclerosis but also to lupus, offering fresh insight into how hidden viral infections may spark long-term immune disruption.

Women face the highest risk of autoimmune disease, possibly due to hormonal influences or differences linked to the X chromosome. Some conditions, however, overwhelmingly affect men. VEXAS syndrome, discovered in 2020, typically strikes men over 50 with severe symptoms that include breathing problems and blood clots.

Treating autoimmune diseases remains complex. The global market for therapies exceeds $100 billion (€87 billion) annually, yet many patients still navigate trial-and-error treatment plans. While high-dose steroids and broad immune-suppressing drugs were once the main options, newer treatments now target specific molecules. The most promising new approach involves CAR-T therapy — originally developed for cancer — which wipes out malfunctioning immune cells and allows healthier ones to grow back. Early trials show potential benefits for lupus, myositis, and other conditions.

Scientists hope that continued research will bring earlier detection, better tools to prevent disease onset, and therapies that address root causes rather than symptoms.

Continue Reading

Trending