Health
Global Rise in Early-Onset Cancer Linked to Obesity and Lifestyle Factors
A major international study has found that several forms of cancer are rising sharply among younger adults worldwide, with obesity and lifestyle changes emerging as key drivers behind the trend.
Published this week in the Annals of Internal Medicine, the study analysed cancer data from 42 countries across five continents between 2003 and 2017. It examined 13 cancer types previously reported to be increasing among younger people, confirming that several are indeed becoming more common in adults aged 20 to 49.
Thyroid, breast, colorectal, kidney, endometrial cancers and leukemia all showed consistent growth across most of the countries studied. Thyroid cancer recorded the steepest rise, with an average annual increase of 3.57%, followed by kidney cancer at 2.21% and endometrial cancer at 1.66%. Colorectal cancer, one of the most closely monitored malignancies among younger populations, rose by 1.45% annually on average. In nearly 70% of countries, new colorectal cancer diagnoses grew faster in younger adults than in older populations.
The researchers said the simultaneous rise across multiple cancer types points to shared risk factors. These may include the global surge in obesity, poor dietary habits, sedentary lifestyles, and widespread antibiotic use, all of which can affect gut health and metabolism.
However, experts emphasized that older adults still account for the majority of cancer diagnoses. While rates among younger adults are climbing, the overall burden remains concentrated in older populations. For instance, in the United States, around 50,000 women under 50 were diagnosed with breast cancer in 2022, compared to more than 210,000 cases in those over 50.
The study’s authors urged caution against focusing prevention efforts solely on early-onset cases, arguing instead for broader public health measures and more research into the underlying causes. “These findings can help guide future research and clinical priorities, including treatment strategies and support needs for younger cancer patients,” the report concluded.
A separate study published in JAMA Internal Medicine last month, however, questioned whether the apparent rise reflects a genuine increase in disease or improved detection. That research found that while diagnoses of several early-onset cancers—such as thyroid, kidney, colorectal, and pancreatic—have doubled since 1992, mortality rates have remained largely unchanged.
The findings suggest that better screening and overdiagnosis could explain part of the increase, rather than a true surge in life-threatening cancers. The authors warned that labeling early-onset cancers as an “epidemic” could lead to unnecessary testing and treatments, imposing emotional, physical, and financial strain on otherwise healthy young adults.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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