Health
Men’s Brains Shrink Faster with Age, But Alzheimer’s Still Strikes Women More Often, Study Finds
Men experience faster brain shrinkage as they age than women, yet Alzheimer’s disease remains nearly twice as common in women, according to a new study that challenges long-held assumptions about the roots of the gender gap in dementia.
The research, published this week in the Proceedings of the National Academy of Sciences (PNAS), examined more than 12,000 brain scans from nearly 5,000 healthy individuals aged 17 to 95. The findings show that while men’s brains show a steeper rate of decline across several key regions, this does not explain why women are far more likely to develop Alzheimer’s disease.
According to the World Health Organization (WHO), around 57 million people were living with dementia in 2021, with nearly 10 million new cases recorded annually. Alzheimer’s disease — the most common form of dementia — disproportionately affects women, with one in five developing the disease by age 45, compared to one in ten men.
For decades, scientists have sought to determine whether structural differences in how male and female brains age could explain this disparity. However, the new study suggests otherwise.
Researchers found that men’s brains tend to shrink faster in multiple regions linked to memory, sensory processing, and movement. The postcentral cortex — the part of the brain that processes sensations such as touch and pain — declined by 2% per year in men, compared to 1.2% in women. Men also exhibited greater thinning in the cerebral cortex, particularly in regions tied to memory and visual recognition, such as the parahippocampal and fusiform areas.
Additionally, men showed more pronounced decline in subcortical structures including the putamen and caudate, which are critical for movement control. Women, by contrast, showed more fluid accumulation in the brain’s ventricles — a sign of normal ageing — but retained more structural integrity overall.
Despite this, women continue to face a far higher risk of Alzheimer’s disease. Experts say the reasons lie beyond structural brain changes, pointing instead to hormonal, genetic, and lifespan factors.
“Hormonal changes after menopause, vascular and immune differences, and genes like APOE ε4 all play a role,” said one of the study’s authors. “Women also live longer than men, which naturally increases their risk.”
Globally, women’s life expectancy is about five years longer than men’s — 73.8 years versus 68.4 years in 2021 — meaning more women live into the age range where Alzheimer’s risk is highest.
The findings underscore the complexity of Alzheimer’s and the need to explore biological and environmental factors beyond simple brain volume loss. As the researchers concluded, the key to understanding women’s greater vulnerability to dementia “will not be found in brain scans alone.”
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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