Health
Study Reveals Why Weight Loss Is Often Followed by Regain: The ‘Yo-Yo’ Effect Explained
Losing weight can be an arduous process, with many individuals finding it difficult to maintain their weight loss over time. This phenomenon, known as the “yo-yo effect,” has long perplexed researchers. A new study from ETH Zurich in Switzerland offers a molecular explanation for why keeping weight off can be so challenging.
Published in the journal Nature, the study highlights how the body’s fat cells retain a “memory” of obesity, even after significant weight loss. This memory is linked to epigenetics, a process where changes in gene activity occur due to environmental factors like diet and lifestyle.
The study suggests that when a person is overweight, their fat cells may develop lasting epigenetic markers that remain even after weight loss. These markers disrupt the normal function of fat cells, making them more likely to store fat and respond to dietary changes in ways similar to when the person was obese. As a result, despite losing weight, the body behaves as though it is still in an overweight state, which could contribute to the difficulty in maintaining weight loss.
To reach these conclusions, the researchers studied fat tissue samples from individuals who had undergone weight-loss surgeries, such as gastric bypass or stomach reduction. They found that even two years after surgery, the fat cells of these individuals continued to behave as if they were still overweight.
In addition, the team conducted an experiment with mice to observe similar effects. After making the mice obese by feeding them a high-fat diet, the researchers switched them to a standard diet to induce weight loss. The mice showed that their fat cells retained markers of obesity even after losing weight. When reintroduced to a high-fat diet, these mice regained weight more quickly, and it was easier for them to become obese again.
While the researchers did not investigate how long this “cell memory” lasts, co-author Laura Hinte noted that fat cells are long-lived and can persist for up to ten years before being replaced by new ones.
Ferdinand von Meyenn, a professor of nutrition and metabolic epigenetics at ETH Zurich, emphasized the importance of preventing obesity in the first place. He explained, “It’s precisely because of this memory effect that it’s so important to avoid being overweight in the first place. Because that’s the simplest way to combat the yo-yo phenomenon.”
This groundbreaking study provides new insight into the biological factors behind weight loss struggles, offering hope for more effective strategies to combat the yo-yo effect in the future.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
AI Models Show Ability to Mimic Human Emotions, Offering New Pathways for Mental Health Research
Health
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