Health
Study Reveals Why Weight Loss Is Often Followed by Regain: The ‘Yo-Yo’ Effect Explained
Losing weight can be an arduous process, with many individuals finding it difficult to maintain their weight loss over time. This phenomenon, known as the “yo-yo effect,” has long perplexed researchers. A new study from ETH Zurich in Switzerland offers a molecular explanation for why keeping weight off can be so challenging.
Published in the journal Nature, the study highlights how the body’s fat cells retain a “memory” of obesity, even after significant weight loss. This memory is linked to epigenetics, a process where changes in gene activity occur due to environmental factors like diet and lifestyle.
The study suggests that when a person is overweight, their fat cells may develop lasting epigenetic markers that remain even after weight loss. These markers disrupt the normal function of fat cells, making them more likely to store fat and respond to dietary changes in ways similar to when the person was obese. As a result, despite losing weight, the body behaves as though it is still in an overweight state, which could contribute to the difficulty in maintaining weight loss.
To reach these conclusions, the researchers studied fat tissue samples from individuals who had undergone weight-loss surgeries, such as gastric bypass or stomach reduction. They found that even two years after surgery, the fat cells of these individuals continued to behave as if they were still overweight.
In addition, the team conducted an experiment with mice to observe similar effects. After making the mice obese by feeding them a high-fat diet, the researchers switched them to a standard diet to induce weight loss. The mice showed that their fat cells retained markers of obesity even after losing weight. When reintroduced to a high-fat diet, these mice regained weight more quickly, and it was easier for them to become obese again.
While the researchers did not investigate how long this “cell memory” lasts, co-author Laura Hinte noted that fat cells are long-lived and can persist for up to ten years before being replaced by new ones.
Ferdinand von Meyenn, a professor of nutrition and metabolic epigenetics at ETH Zurich, emphasized the importance of preventing obesity in the first place. He explained, “It’s precisely because of this memory effect that it’s so important to avoid being overweight in the first place. Because that’s the simplest way to combat the yo-yo phenomenon.”
This groundbreaking study provides new insight into the biological factors behind weight loss struggles, offering hope for more effective strategies to combat the yo-yo effect in the future.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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