Health
Major Genetic Study Reveals Shared Biological Roots Across Mental Health Conditions
A new large-scale genetic study suggests that different mental health conditions may have far more in common at a biological level than previously thought. Researchers from the University of Colorado Boulder and Mass General Brigham in the United States said the findings of this study could eventually improve how mental health conditions are diagnosed and treated, especially for people who live with more than one diagnosis.
The study analysed DNA from more than six million people, including over one million diagnosed with at least one mental health condition. According to the World Health Organization, more than a billion people worldwide live with mental health challenges.
“Right now, we diagnose psychiatric disorders based on what we see in the room, and many people will be diagnosed with multiple disorders. That can be hard to treat and disheartening for patients,” said Andrew Grotzinger, assistant professor of psychology and neuroscience at the University of Colorado Boulder and corresponding author of the study.
The research examined 14 psychiatric disorders and found that most of the genetic differences between people with and without these conditions could be explained by just five broad genetic patterns. These patterns involved 238 genetic variants that influence brain development and function. Based on these shared features, researchers grouped the conditions into five categories.
One group included disorders with compulsive traits, such as anorexia nervosa, Tourette’s disorder, and obsessive-compulsive disorder. Another encompassed internalising conditions, including depression, anxiety, and post-traumatic stress disorder. A third group focused on substance use disorders, while a fourth covered neurodevelopmental conditions such as autism and attention-deficit hyperactivity disorder. The final group included bipolar disorder and schizophrenia, which were found to share around 70 percent of their genetic signals.
“Genetically, we saw that they are more similar than they are unique,” Grotzinger said, noting that these two conditions are rarely diagnosed together but have overlapping biological roots.
The findings challenge the traditional view that mental health conditions are largely separate illnesses. Instead, the study suggests that many disorders may be driven by common biological processes. While the results are not yet being used to change diagnostic practices, the team hopes they will inform future updates to the Diagnostic and Statistical Manual of Mental Disorders, the handbook used by mental health professionals worldwide.
“This work provides the best evidence yet that there may be things that we are currently giving different names to that are actually driven by the same biological processes,” Grotzinger said. “By identifying what is shared across these disorders, we can hopefully come up with strategies to target them in a different way that doesn’t require four separate pills or four separate psychotherapy interventions.”
The study also identified specific biological pathways linked to different disorder groups. For example, genes affecting excitatory neurons were more active in bipolar disorder and schizophrenia, while variants linked to oligodendrocytes, cells that maintain the brain’s wiring, were more common in depression and anxiety. Some shared genetic factors may influence brain development even before birth, while others act later in life, potentially explaining why multiple conditions often occur in the same person.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
AI Models Show Ability to Mimic Human Emotions, Offering New Pathways for Mental Health Research
Health
AI Saves Clinicians Weeks of Work but Health Systems Struggle to Keep Up, Philips Report Finds
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