Health

Major Genetic Study Reveals Shared Biological Roots Across Mental Health Conditions

Published

5 months ago

December 16, 2025

A new large-scale genetic study suggests that different mental health conditions may have far more in common at a biological level than previously thought. Researchers from the University of Colorado Boulder and Mass General Brigham in the United States said the findings of this study could eventually improve how mental health conditions are diagnosed and treated, especially for people who live with more than one diagnosis.

The study analysed DNA from more than six million people, including over one million diagnosed with at least one mental health condition. According to the World Health Organization, more than a billion people worldwide live with mental health challenges.

“Right now, we diagnose psychiatric disorders based on what we see in the room, and many people will be diagnosed with multiple disorders. That can be hard to treat and disheartening for patients,” said Andrew Grotzinger, assistant professor of psychology and neuroscience at the University of Colorado Boulder and corresponding author of the study.

The research examined 14 psychiatric disorders and found that most of the genetic differences between people with and without these conditions could be explained by just five broad genetic patterns. These patterns involved 238 genetic variants that influence brain development and function. Based on these shared features, researchers grouped the conditions into five categories.

One group included disorders with compulsive traits, such as anorexia nervosa, Tourette’s disorder, and obsessive-compulsive disorder. Another encompassed internalising conditions, including depression, anxiety, and post-traumatic stress disorder. A third group focused on substance use disorders, while a fourth covered neurodevelopmental conditions such as autism and attention-deficit hyperactivity disorder. The final group included bipolar disorder and schizophrenia, which were found to share around 70 percent of their genetic signals.

“Genetically, we saw that they are more similar than they are unique,” Grotzinger said, noting that these two conditions are rarely diagnosed together but have overlapping biological roots.

The findings challenge the traditional view that mental health conditions are largely separate illnesses. Instead, the study suggests that many disorders may be driven by common biological processes. While the results are not yet being used to change diagnostic practices, the team hopes they will inform future updates to the Diagnostic and Statistical Manual of Mental Disorders, the handbook used by mental health professionals worldwide.

“This work provides the best evidence yet that there may be things that we are currently giving different names to that are actually driven by the same biological processes,” Grotzinger said. “By identifying what is shared across these disorders, we can hopefully come up with strategies to target them in a different way that doesn’t require four separate pills or four separate psychotherapy interventions.”

The study also identified specific biological pathways linked to different disorder groups. For example, genes affecting excitatory neurons were more active in bipolar disorder and schizophrenia, while variants linked to oligodendrocytes, cells that maintain the brain’s wiring, were more common in depression and anxiety. Some shared genetic factors may influence brain development even before birth, while others act later in life, potentially explaining why multiple conditions often occur in the same person.

Health

Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise

Published

2 days ago

May 22, 2026

Web Reporter

A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.

The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.

The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.

Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.

Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.

In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.

Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.

The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.

According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.

While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.

The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.

Health

Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns

Published

3 days ago

May 21, 2026

Web Reporter

Cases of bacterial sexually transmitted infections across Europe have climbed to record levels after rising steadily for a decade, according to new figures released by the European Centre for Disease Prevention and Control.

The agency said infections such as gonorrhoea and syphilis reached their highest levels since European surveillance began, raising concerns among health officials about the growing impact on reproductive and long-term health.

“Sexually transmitted infections have been on the rise for 10 years and reached record high levels in 2024,” said Bruno Ciancio, head of the ECDC unit for directly transmitted and vaccine-preventable diseases.

The report found that gonorrhoea cases rose to 106,331 in 2024, marking a 303 percent increase since 2015. Syphilis infections more than doubled over the same period, reaching 45,577 cases. Chlamydia remained the most commonly reported infection, with 213,443 recorded cases.

Health officials warned that untreated infections can lead to serious complications, including infertility, chronic pain and neurological or cardiovascular problems linked to advanced syphilis.

The steepest increase was recorded in gonorrhoea cases. The ECDC said the 2024 notification rate was the highest since monitoring began in 2009.

Gonorrhoea, caused by the bacterium Neisseria gonorrhoeae, often shows no symptoms, particularly among women, making diagnosis and treatment more difficult and allowing transmission to continue unnoticed.

Between 2023 and 2024, gonorrhoea rates rose by 7.9 percent among men, with the highest levels seen in those aged 25 to 34. More than half of reported cases involved men who have sex with men.

Among women, reported gonorrhoea cases fell by 8.6 percent overall, although the highest rates remained among women aged between 20 and 24.

The ECDC said high infection rates among women of reproductive age remained concerning because of the risk of complications affecting fertility and reproductive health.

Ireland, Malta, Iceland, Luxembourg, Denmark and Spain recorded the highest gonorrhoea rates in 2024.

The report also highlighted a sharp increase in congenital syphilis, a condition in which the infection passes from a pregnant woman to her unborn child. Cases nearly doubled from 2023 levels and reached the highest point recorded since 2009.

Between 2015 and 2024, Bulgaria reported the highest number of congenital syphilis cases, followed by Portugal and Hungary.

The ECDC said congenital syphilis is preventable and noted that the World Health Organization European region has set a target of reducing cases to fewer than one per 100,000 live births by 2030.

Experts pointed to changing sexual behaviour as a major factor behind the increase in infections. Josep Mallolas, head of the HIV/AIDS unit at Hospital Clínic Barcelona, said condom use had declined while the number of sexual partners had increased, particularly among younger age groups.

The ECDC added that expanded screening programmes, improved testing access and better reporting systems may also partly explain the rise in detected cases. Officials called for broader prevention campaigns, increased testing and stronger monitoring efforts across Europe.

Health

White House Rejects Report It Blocked Return of Ebola-Infected US Doctor

Published

3 days ago

May 21, 2026

Web Reporter

The White House has denied reports that the United States blocked the return of an American missionary doctor infected with Ebola while working in the Democratic Republic of Congo, after a newspaper report claimed his evacuation to the US had been delayed over political and public health concerns.

The report, published by The Washington Post and citing unnamed sources familiar with the matter, alleged that US officials initially refused to allow Dr. Peter Stafford to return home after he contracted Ebola in eastern Congo. According to the report, Stafford was eventually flown to Germany for treatment after delays linked to internal discussions within the administration.

White House spokesman Kush Desai strongly rejected the claims, calling the report “absolutely false.”

“The Trump administration’s overriding and sole priority is the health and safety of the American people,” Desai said in a statement. He added that Berlin’s Charité hospital is internationally recognised for treating highly infectious diseases and offers care comparable to top American medical centres.

Dr. Stafford had been working in Bunia, in eastern Congo, when he treated a patient suffering from severe abdominal pain. The illness was initially suspected to be linked to gallbladder complications, but the patient later died and was believed to have been infected with Ebola. A test confirming the disease was reportedly not conducted before burial.

Several days later, Stafford developed symptoms including fever, severe fatigue, pain and chills. He was eventually transported to Germany for specialist treatment at the Charité hospital in Berlin, which has extensive experience handling dangerous viral outbreaks.

The doctor’s wife and four children have also been admitted to the hospital’s isolation unit after US authorities requested assistance from Germany, according to the German Federal Health Ministry.

The controversy has revived memories of the 2014 Ebola outbreak in West Africa, when two infected American aid workers were flown back to the United States for treatment. At the time, Donald Trump publicly criticised the decision in social media posts, warning against bringing Ebola patients into the country.

The latest outbreak in Congo has been identified as the Bundibugyo strain of Ebola, which carries a fatality rate estimated between 25 and 50 percent. Health officials say there are currently no approved vaccines or targeted treatments specifically for this strain.

Authorities in Congo have reported nearly 600 suspected cases and 139 deaths so far, although officials believe the real number of infections may be higher because of limited testing and surveillance capacity in affected regions.

Meanwhile, heightened concerns over Ebola have also affected international travel. A recent Air France flight from Paris to Detroit was diverted to Canada after US authorities reportedly denied the aircraft entry into American airspace because a passenger had recently travelled to Congo.

Despite the concerns surrounding his evacuation, reports from Berlin indicate Stafford’s condition has begun to improve and that he is now able to eat again.