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Major Genetic Study Reveals Shared Biological Roots Across Mental Health Conditions

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A new large-scale genetic study suggests that different mental health conditions may have far more in common at a biological level than previously thought. Researchers from the University of Colorado Boulder and Mass General Brigham in the United States said the findings of this study could eventually improve how mental health conditions are diagnosed and treated, especially for people who live with more than one diagnosis.

The study analysed DNA from more than six million people, including over one million diagnosed with at least one mental health condition. According to the World Health Organization, more than a billion people worldwide live with mental health challenges.

“Right now, we diagnose psychiatric disorders based on what we see in the room, and many people will be diagnosed with multiple disorders. That can be hard to treat and disheartening for patients,” said Andrew Grotzinger, assistant professor of psychology and neuroscience at the University of Colorado Boulder and corresponding author of the study.

The research examined 14 psychiatric disorders and found that most of the genetic differences between people with and without these conditions could be explained by just five broad genetic patterns. These patterns involved 238 genetic variants that influence brain development and function. Based on these shared features, researchers grouped the conditions into five categories.

One group included disorders with compulsive traits, such as anorexia nervosa, Tourette’s disorder, and obsessive-compulsive disorder. Another encompassed internalising conditions, including depression, anxiety, and post-traumatic stress disorder. A third group focused on substance use disorders, while a fourth covered neurodevelopmental conditions such as autism and attention-deficit hyperactivity disorder. The final group included bipolar disorder and schizophrenia, which were found to share around 70 percent of their genetic signals.

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“Genetically, we saw that they are more similar than they are unique,” Grotzinger said, noting that these two conditions are rarely diagnosed together but have overlapping biological roots.

The findings challenge the traditional view that mental health conditions are largely separate illnesses. Instead, the study suggests that many disorders may be driven by common biological processes. While the results are not yet being used to change diagnostic practices, the team hopes they will inform future updates to the Diagnostic and Statistical Manual of Mental Disorders, the handbook used by mental health professionals worldwide.

“This work provides the best evidence yet that there may be things that we are currently giving different names to that are actually driven by the same biological processes,” Grotzinger said. “By identifying what is shared across these disorders, we can hopefully come up with strategies to target them in a different way that doesn’t require four separate pills or four separate psychotherapy interventions.”

The study also identified specific biological pathways linked to different disorder groups. For example, genes affecting excitatory neurons were more active in bipolar disorder and schizophrenia, while variants linked to oligodendrocytes, cells that maintain the brain’s wiring, were more common in depression and anxiety. Some shared genetic factors may influence brain development even before birth, while others act later in life, potentially explaining why multiple conditions often occur in the same person.

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Breast Cancer Screening Gaps Across Europe Leave Women Facing Unequal Access to Early Diagnosis

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A breast biopsy can bring days of uncertainty, fear and difficult memories, particularly for women with a family history of cancer. For Euronews reporter Monica Pinna, a week-long wait for test results became a personal experience of the emotional strain involved in investigating a possible diagnosis, as well as the inequalities affecting breast cancer screening and care across Europe.

Pinna had delayed a routine breast examination for around two years before attending an appointment in France. Her mammogram appeared normal, but an ultrasound revealed a suspicious area that required a biopsy. She underwent the procedure two days later and waited seven days for the results.

During that period, she recalled relatives who had survived breast cancer and others who had died from the disease. Although the uncertainty disrupted her work and daily life, the doctor eventually confirmed that there was no cancer.

Her experience highlighted a wider problem: access to early detection and timely diagnosis varies considerably between European countries.

When breast cancer is detected before it spreads, five-year survival rates approach 100%, compared with 38% for women diagnosed at an advanced stage, according to figures cited in the report. The European Commission has allocated around €80 million through its Europe’s Beating Cancer Plan to strengthen screening, but access remains uneven.

Differences in screening arrangements, appointment availability, out-of-pocket costs and public awareness all affect women’s chances of receiving an early diagnosis. Research by the European Union and the Organisation for Economic Co-operation and Development (OECD) has also identified social inequalities as a factor.

The time between screening and diagnosis varies across the continent. A study cited in the report found median waiting times ranging from eight days in Denmark to 32 days in Romania.

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Maria Assunta, who lives in Sardinia, experienced a considerably longer process. At 46, a routine ultrasound identified a four-centimetre lump. She waited a month for a biopsy and another three weeks to receive her diagnosis. She is now in follow-up care, with examinations every six months, and describes the treatment she received as excellent.

Participation in organised screening programmes also remains inconsistent. In France, fewer than half of eligible women take part. Although screening rates increased in nine EU countries with available data compared with 2019, progress has stalled in many others.

Around 360,000 women in the EU are diagnosed with breast cancer each year, including approximately 61,000 in France. Estimates suggest that one in 11 women will develop the disease during their lifetime.

Access to psychological support is another concern. The OECD’s 2026 European Cancer Inequalities Report found that only 16 EU countries include psychological care in their cancer treatment pathways, alongside Norway and Iceland.

In Italy, a 2024 study of around 3,000 cancer patients found that only 20% had received psychological support. The Italian Federation of Voluntary Associations in Oncology estimates that specialised psycho-oncology services are available in only around 20% of hospitals.

Cancer survivors and medical volunteers have established initiatives to help address these gaps, offering activities such as yoga, Qigong and emotional support. However, provision remains limited and often depends on voluntary organisations.

Pinna’s experience ended with an all-clear, but she said it had changed her approach to screening. She hopes sharing her story will encourage women to attend regular examinations, while calling for faster diagnosis, wider access to treatment and psychological support across Europe.

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Pilot Fatigue Raises Safety Concerns as Survey Finds Widespread Microsleeps

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Pilot fatigue remains a significant aviation safety concern, with a new survey finding that many pilots continue flying while exhausted rather than declaring themselves unfit for duty because of concerns about their employers’ reactions.

The European Cockpit Association (ECA) said fear of career consequences, reluctance to draw attention to fatigue and concerns about inconveniencing employers were among the main barriers preventing pilots from reporting that they were too tired to fly.

The survey, conducted by aviation consultancy Baines Simmons, collected responses from 7,200 pilots across 32 countries. More than half of respondents said they had flown while tired, while over 76% reported experiencing at least one microsleep on the flight deck during the previous four weeks.

Microsleeps are brief, involuntary episodes of sleep that can occur when a person is severely fatigued. Other warning signs include head nodding, difficulty keeping the eyes open and reduced alertness, all of which can compromise a pilot’s ability to respond to changing conditions during a flight.

More than half of the pilots surveyed said that, at least once in the previous three months, they had operated a flight before later realising they should have declared themselves unfit for duty because of fatigue.

Concern about management’s reaction was the most frequently reported barrier, cited by 47% of respondents. Another 44% said they did not want to draw attention to themselves, while 35% were reluctant to inconvenience their employer.

“When pilots fear career consequences, fatigue goes unreported and the risk returns to the cockpit,” said Captain Coen George, an ECA board director.

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Fatigue can result from insufficient sleep, long or demanding duty periods and inadequate recovery time between assignments. The report also highlighted cumulative fatigue, which builds up over successive duties and can be harder for pilots to recognise before their performance is affected.

Despite widespread awareness of the risks, confidence in reporting procedures remains low. Although 82% of respondents knew how to submit a fatigue report, only 12% said they trusted the reporting system. Just 11% said fatigue reports had resulted in operational changes intended to improve safety.

Half of those surveyed described fatigue risks at their airlines as poorly managed or not managed at all.

The findings echo concerns raised by the European Union Aviation Safety Agency (EASA), which identified aircrew fatigue as a prominent safety issue in a report published in June 2026.

EASA linked fatigue to several operational and employment-related factors, including flight scheduling, short-notice roster changes and the use of commanders’ discretion to extend duty periods beyond planned limits.

The agency called for targeted safety initiatives to improve reporting and awareness, alongside workplace cultures that allow personnel to declare themselves too tired to work without fear of reprimand.

The ECA survey suggests that improving formal reporting procedures alone may not be sufficient. Building trust in those systems and ensuring that fatigue reports lead to meaningful operational changes remain important challenges for airlines seeking to protect flight safety.

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One in Three Young US Adults Uses AI for Drug Information, Study Finds

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One in three young adults in the United States has used artificial intelligence chatbots to seek information about drugs and alcohol, raising concerns among researchers about the potential health risks of inaccurate or misleading advice.

A study published in JMIR Formative Research found that 32% of 995 adults aged 18 to 29 had used tools such as ChatGPT, Google Gemini and Meta AI to obtain information related to substance use.

Among those who used AI for this purpose, nearly half said they did so at least once a month. About 12% reported using chatbots for substance-related information weekly, while 4% said they used them daily or almost daily.

“Using these tools can lead to misinformed or otherwise risky substance-use behaviour among young people, who are the age group most affected by adverse effects of substance use,” said Mireia Triguero Roura, a postdoctoral researcher at Rutgers University and lead author of the study.

The survey was conducted online in April 2026. Researchers found that AI users were primarily seeking information about the risks and consequences of substance use. Nearly 93% of respondents who had asked chatbots substance-related questions cited this as a reason.

Around half sought information about specific substances, including questions about dosage, while 35% used AI to explore substance use disorders and addiction.

The findings suggest that chatbots are supplementing rather than replacing traditional online searches. Among respondents who had used AI for substance-related information, 93% had also used Google search for similar purposes.

Participants generally rated AI tools positively for helpfulness, reliability and trustworthiness. Those who used chatbots for substance-related questions gave them an average trustworthiness score of 3.66 out of five, compared with 3.51 for general use.

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Researchers cautioned, however, that positive user perceptions do not establish whether chatbot responses are medically accurate or safe. Incorrect information about substances, their effects or appropriate responses to health risks could influence decisions and encourage harmful behaviour.

The study also identified differences in use according to race and sex. Black respondents had 2.52 times the adjusted odds of reporting substance-related AI use compared with white respondents. Male respondents had approximately twice the adjusted odds of female respondents.

Triguero Roura said these differences could reflect variations in access to healthcare, experiences of stigma, trust in health services and patterns of seeking health information.

The researchers said further studies are needed to assess the accuracy of chatbot answers to drug-related questions and determine how users interpret and act on the information they receive.

They also called for more research into why certain demographic groups are more likely to use AI for substance-related queries.

As generative AI becomes a more common source of information for young adults, the findings highlight the need to understand whether these tools can provide reliable health guidance and how potential risks can be reduced.

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