Health
French Study Finds COVID-19 Vaccines Reduce Risk of Death from All Causes
Adults who received at least one dose of a COVID-19 vaccine have a lower risk of death, regardless of the cause, according to a new study conducted in France. The research shows that individuals vaccinated with at least one mRNA COVID-19 dose had a reduced risk of mortality compared with those who remained unvaccinated.
The study examined 28 million French adults aged 18 to 59 and tracked outcomes over a median period of 45 months. Researchers found that vaccinated individuals had a 74 percent lower risk of dying from severe COVID-19 and a 25 percent lower risk of death from all causes. The protective effect was attributed not only to the vaccines’ strong defense against severe infection but also to fewer complications related to long COVID, which may contribute to overall mortality reduction.
The research was conducted by Epi-Phare, a scientific interest group overseen by the French National Agency for Medicines and Health Products Safety (ANSM), in collaboration with the French National Health Insurance Fund. The team analysed data from the French National Health Data System, comparing 22.7 million people vaccinated between May and October 2021 with 5.9 million unvaccinated individuals as of November 1, 2021.
During the follow-up period, 98,429 deaths from all causes (0.4 percent) occurred among vaccinated participants, compared with 32,662 deaths (0.6 percent) among the unvaccinated. The study found no evidence of increased mortality from cancer, cardiovascular disease, accidental injury, or any other major cause. In every category, vaccinated individuals had equal or lower death rates than their unvaccinated counterparts.
Researchers concluded that a causal link between mRNA vaccination and excess long-term mortality appears highly unlikely, underscoring the safety and efficacy of the vaccines.
The study is the largest to date assessing the long-term safety of COVID-19 mRNA vaccines in the general adult population. The findings, however, are limited to adults under 60 and do not directly reflect outcomes for older populations, who face the highest risk from COVID-19.
In the European Union, more than 976 million COVID-19 vaccine doses had been administered as of February 2023, according to the European Centre for Disease Prevention and Control (ECDC). Vaccination programs have continued, with tens of millions of additional booster doses given each season.
The research provides robust evidence supporting the long-term benefits of COVID-19 vaccination in reducing deaths from the virus and other causes. Public health experts say the findings may reassure vaccine-hesitant individuals and reinforce the importance of ongoing vaccination efforts, particularly among younger adults who may perceive their risk from COVID-19 as low.
This study adds to a growing body of international research demonstrating that mRNA COVID-19 vaccines are both safe and effective, offering protection not only against severe illness but also against overall mortality in the adult population.
Health
Taking the Stairs Could Cut Risk of Heart Disease Death, Study Finds
Taking the stairs instead of using a lift could significantly reduce the risk of cardiovascular disease and premature death, according to a major study examining the health benefits of regular stair climbing.
Researchers from the University of East Anglia and Norfolk and Norwich University Hospital found that people who regularly climbed stairs had a 39 percent lower risk of dying from cardiovascular disease than those who rarely used stairs. They also had a 24 percent lower risk of death from any cause.
The study found that regular stair climbing was also associated with a lower risk of developing serious cardiovascular conditions, including heart attacks, strokes and heart failure.
The research team analysed health data from more than 480,000 people aged between 35 and 84. The findings were based on nine high-quality studies, with participants followed for a median period of 14 years.
Vassilios Vassiliou of Norwich Medical School at the University of East Anglia said stair climbing was a practical way to add physical activity to everyday routines. He described it as an activity that is often overlooked despite being easy to perform without special equipment or facilities.
Unlike structured exercise at a gym, climbing stairs can be included naturally in daily activities at home, at work or while travelling. Sophie Paddock, also from Norwich Medical School, said the activity could be particularly useful for people who have limited time or do not have convenient access to exercise facilities.
The researchers said even short periods of stair climbing several times a week could provide measurable health benefits. The activity can improve cardiorespiratory fitness and help lower cholesterol, both of which are linked to better cardiovascular health.
The amount of stair climbing also appeared to matter. Some of the studies reviewed by the researchers found that people who climbed more stairs generally experienced greater health benefits. However, even smaller amounts of activity were associated with positive changes.
The findings are particularly relevant as more than a quarter of adults worldwide do not meet recommended levels of physical activity. The researchers said encouraging simple forms of movement in everyday environments could help address this problem.
Workplaces, homes and public buildings could all play a role by making stair use easier and more appealing. Choosing stairs over lifts when possible may provide an accessible form of physical activity without requiring people to set aside additional time for a workout.
The findings were presented at a scientific congress of the European Society of Cardiology. Researchers said the results highlight how small changes in daily routines can contribute to better long-term health and may help reduce the burden of cardiovascular disease.
Health
Children Who Play Alone May Still Feel Happy and Connected, Study Finds
Children who spend much of their school day playing alone may not necessarily be lonely or unhappy, according to a new study from researchers at the University of Georgia in the United States.
The research suggests that some children simply enjoy their own company while maintaining satisfying friendships and a sense of belonging among their classmates. Researchers say the key factor may not be how often a child chooses to be alone, but whether they still feel connected to others.
The study involved 473 children aged between nine and 11 at several elementary schools in Georgia. Participants were asked to identify classmates who often played alone despite getting along with other students. They also answered questions about the importance they placed on belonging and their satisfaction with friendships and relationships within their classes.
Researchers found a clear difference between children who preferred solitude while still valuing social connections and those who placed little importance on belonging to a peer group.
Children who enjoyed spending time alone but considered belonging important generally reported being satisfied with both their close friendships and wider relationships at school. Researchers said these children may accept enough invitations to remain socially connected while choosing to spend some of their free time alone.
Rachael Pfanz, the study’s corresponding author and an elementary school psychologist, said these children can prefer doing their own activities without having difficulty getting along with classmates.
The findings were different for children who did not consider belonging important. They were more likely to report weaker relationships with friends and classmates.
Researchers warned that repeatedly turning down invitations can eventually affect a child’s social opportunities. Classmates may stop asking them to join activities, potentially leaving them with fewer chances to develop or maintain friendships.
Michele Lease, a professor of educational psychology at the University of Georgia and a co-author of the study, compared social interaction with other activities that benefit people even when they may not always feel like participating.
The researchers said adults should avoid assuming that every child who plays alone needs to be encouraged to join a large group immediately. Pressuring a child into a busy activity could make the situation uncomfortable rather than helping them build connections.
Instead, adults could introduce children to smaller groups or classmates who share similar interests. A child who enjoys drawing, reading, building or another individual activity may find it easier to connect with peers who have the same interests.
Pfanz said joining a large playground game, such as soccer, may feel overwhelming for a child who already prefers playing alone.
The researchers said the findings are particularly relevant to fourth- and fifth-grade students, a period when friendship groups become more established and children become better at recognising whether classmates are choosing solitude or experiencing social exclusion.
The study suggests that solitude itself should not automatically be viewed as a problem. What may matter more is whether children have meaningful relationships and continue to feel that they belong.
Health
Good Vascular Health in Midlife Linked to Longer Dementia-Free Life
Maintaining healthy blood pressure, avoiding diabetes and not smoking during middle age may help people spend more years of their lives free from dementia, according to new research.
A study of more than 12,000 participants found that people without the three major vascular risk factors between the ages of 48 and 68 could gain nearly 13 additional years without developing dementia compared with those who had all three conditions.
The findings highlight the importance of managing cardiovascular health during midlife as researchers continue to examine ways to reduce the growing global burden of dementia.
Dementia affects millions of people worldwide, with about 10 million new cases diagnosed each year, according to the World Health Organization. The number of people living with the condition is expected to exceed 150 million by 2050.
Researchers are increasingly examining factors that can be changed earlier in life, including smoking, high blood pressure and diabetes, because these conditions can affect blood vessels and contribute to problems affecting the brain.
The study, published in Neurology Open Access, defined good vascular health as having no diabetes, hypertension or smoking history during middle age.
Researchers found that participants with all three risk factors faced almost three times the risk of developing dementia compared with people who had none of them.
At age 55, people with no vascular risk factors could expect to live an average of 30 more years without dementia. Those with one risk factor had an average of 26 dementia-free years, while people with two had about 21 years.
Participants with all three risk factors could expect just over 17 years without dementia. The difference between those with no risk factors and those with all three was therefore about 13 years.
The researchers said the results suggest that protecting vascular health during midlife could have a substantial effect on brain health later in life.
“Our findings argue that people need to actively avert these factors in midlife as a strategy for preserving brain health for more than a decade,” said senior investigator Josef Coresh.
The study also identified differences between men and women. Women generally had more dementia-free years than men across the groups. Among participants with all three risk factors, women averaged about 18 years without dementia, compared with 16 years for men.
The researchers said the findings reinforce the importance of preventing or managing high blood pressure and diabetes and avoiding smoking during middle age.
Coresh said the results could encourage people to pay closer attention to their vascular health from their late 40s onward, potentially helping them maintain cognitive health for longer as they age.
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