Health
Study Links Toddlers’ Gut Health to Later Mental Wellbeing
Children’s gut health in early life could play a key role in shaping their future mental wellbeing, according to new research that highlights the growing evidence of a link between the gut and the brain.
A study published in Nature Communications found that toddlers with higher levels of certain gut bacteria were more likely to develop symptoms of anxiety, depression, and social withdrawal later in childhood. The findings, though based on a small sample, suggest that the gut microbiome — the trillions of microorganisms living in the digestive system — may influence the developing brain in ways that affect emotional health years later.
Researchers from the University of California, Los Angeles (UCLA), and partners in Singapore tracked 55 children over several years, collecting data at ages two, six, and seven-and-a-half. The team analysed stool samples to identify gut bacteria, performed brain scans, and surveyed caregivers about behavioural and emotional symptoms.
They discovered that children who had higher levels of bacteria from the Clostridiales and Lachnospiraceae families at age two were more likely to show “internalising” symptoms — such as anxiety, depression, and social withdrawal — five years later. These same bacterial groups have also been linked to depression in adults.
Bridget Callaghan, senior author of the study and associate professor of psychology at UCLA, said the findings provide early evidence that gut bacteria in infancy and toddlerhood could influence the development of brain circuits related to emotional health.
“By linking early-life microbiome patterns with brain connectivity and later symptoms of anxiety and depression, our study provides early evidence that gut microbes could help shape mental health during the critical school-age years,” Callaghan said.
The researchers believe this connection is driven by the “gut-brain axis” — the two-way communication network between the digestive system and the brain, which plays a role in regulating mood, stress, and cognitive functions.
While the study offers promising insights, scientists caution that its small sample size and focus on children in Singapore mean the findings may not apply to all populations, as gut microbiomes vary widely among individuals and regions.
Callaghan noted that further research is needed to determine whether these bacteria directly cause emotional symptoms and to identify which specific species are responsible. “Once we have that information, there are relatively straightforward ways to change the microbiome, like probiotics or diet, that we could use to address issues,” she added.
The research adds to a growing body of evidence linking gut health to a wide range of physical and mental conditions, including cancer, diabetes, heart disease, insomnia, and premature birth — underscoring the far-reaching influence of the microorganisms that inhabit the human gut.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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