Health
Experimental Alzheimer’s Drug Shows Promise in Reducing Dementia Risk
A new experimental treatment targeting amyloid plaques in the brain has shown promising early results in reducing the risk of Alzheimer’s-related dementia among asymptomatic patients. The drug, gantenerumab, was studied in a small group of individuals genetically predisposed to the neurodegenerative disease.
Researchers tracked 22 patients with genetic mutations that cause an overproduction of amyloid, a protein that clumps together to form plaques in the brain, a hallmark of Alzheimer’s disease. According to findings published in Lancet Neurology, participants who took gantenerumab for eight years saw their risk of developing symptoms drop from 100% to approximately 50%.
Long-Term Treatment May Be Key
The study’s lead author, Randall Bateman, a professor of neurology at Washington University School of Medicine in the U.S., emphasized the significance of the results. “Everyone in this study was destined to develop Alzheimer’s disease, and some of them haven’t yet,” Bateman said. “To give them the best opportunity to stay cognitively normal, we have continued treatment with another anti-amyloid antibody in hopes they will never develop symptoms at all.”
Notably, cognitive benefits were observed only in patients who received the treatment for the full eight years. Those who were treated for only two to three years did not show noticeable improvements, suggesting that long-term preventive therapy may be necessary for effectiveness.
Challenges and Limitations
Despite the encouraging results, experts have pointed out limitations in the study. Charles Marshall, a professor of clinical neurology at Queen Mary University of London, called the findings “very exciting” but noted that the study involved a small number of participants and was a secondary evaluation rather than a primary clinical trial.
Another concern is that gantenerumab is not as effective as some newer amyloid-reducing treatments, suggesting there may be even better options available. The drug was discontinued in 2022 after failing to slow symptoms in a trial involving over 1,900 participants with more common forms of Alzheimer’s disease.
Future Research Needed
While gantenerumab has shown potential in genetically predisposed individuals, further research is required to determine the optimal treatment duration, the effects on non-genetic cases of Alzheimer’s, and possible side effects. Some anti-amyloid drugs have been linked to brain abnormalities and localized swelling, though most side effects resolve on their own. In the study, two participants had to stop taking the drug due to side effects, but no life-threatening adverse effects were reported.
The findings contribute to the growing body of research on anti-amyloid therapies, highlighting the need for continued investigation into more effective Alzheimer’s prevention and treatment strategies.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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