Health
Study Links Gut Bacteria to Increased Risk of Insomnia
A new study has found that certain bacteria in the gut may play a direct role in causing insomnia, suggesting that chronic sleeplessness could be linked to more than just lifestyle factors or stress.
The research, published in General Psychiatry, examined genetic and microbiome data from large groups of people and found evidence of a two-way relationship between the condition and the gut microbiome — the community of bacteria, fungi, and viruses that naturally live in the body.
Insomnia, which affects about 10% of adults regularly and up to 20% occasionally, is typically associated with causes such as stress, caffeine, alcohol consumption, medical conditions, or side effects from medication. Symptoms include difficulty falling asleep, poor sleep quality, and daytime problems such as irritability or fatigue.
While previous studies have suggested a link between gut health and sleep through the so-called gut–brain axis, this latest research offers “preliminary evidence” that the composition of gut bacteria can actively influence the risk of developing insomnia.
Researchers analysed genetic data from nearly 387,000 people with insomnia and microbiome data from around 27,000 individuals. They identified 14 groups of bacteria that increased insomnia risk by 1–4%, and eight groups that lowered the risk by 1–3%. People with insomnia had significantly reduced levels of seven types of bacteria and increased levels of 12 others.
The exact reasons behind the connection remain unclear. One theory suggests that insomnia alters the body’s levels of serotonin and dopamine — key neurotransmitters involved in sleep regulation — which may, in turn, influence gut bacteria. Other possible explanations include immune system regulation, inflammation, and various molecular and cellular mechanisms.
“The intertwined effects of insomnia on gut microbiota, and vice versa, represent a complex bidirectional relationship,” the study authors wrote.
The findings also highlight the possibility of developing microbiome-based treatments for insomnia, such as probiotics, prebiotics, or even faecal microbiota transplants. However, the researchers caution that more work is needed before such interventions could be recommended.
The study has limitations. Most participants were of European descent, meaning the results may not be applicable to all populations. In addition, dietary and lifestyle factors — both of which can influence gut health — were not fully accounted for in the analysis.
Despite these caveats, experts say the research strengthens the case for looking beyond conventional causes of insomnia and exploring how internal biological systems, particularly the gut, can influence sleep. If future studies confirm the findings, it could mark a shift in how chronic insomnia is treated, offering new hope to millions of people worldwide who struggle to get a good night’s rest.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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