Health
Ancient Ice Cave Bacteria in Romania Found Resistant to Modern Antibiotics
A strain of bacteria preserved for thousands of years in a Romanian ice cave has been found to resist multiple modern antibiotics, according to a new study published in Frontiers in Microbiology.
Researchers studying ice cores from Scărișoara Cave in western Romania discovered a cold-adapted bacterium known as Psychrobacter SC65A.3 beneath a 5,000-year-old layer of ice. Despite its ancient origin, the strain showed resistance to 10 antibiotics across eight different classes.
Scărișoara Cave contains one of the largest underground ice blocks in the world, measuring about 100,000 cubic metres and estimated to be around 13,000 years old. A research team drilled a 25-metre ice core from an area known as the Great Hall and analysed ice fragments to isolate bacterial strains. They sequenced the genomes to identify genes linked to survival in low temperatures and antimicrobial resistance.
Cristina Purcarea, a scientist at the Institute of Biology Bucharest of the Romanian Academy and lead author of the study, said the Psychrobacter SC65A.3 strain carries more than 100 genes associated with antibiotic resistance. She noted that the antibiotics to which the strain is resistant are widely used in both oral and injectable treatments for serious infections, including tuberculosis, colitis and urinary tract infections.
Bacteria are known to survive in extreme environments for extended periods, including beneath ancient ice sheets, in permafrost and in deep-sea or glacial ecosystems. Over time, they adapt to harsh conditions, developing mechanisms that allow persistence in cold and nutrient-limited settings.
The findings suggest that antibiotic resistance can evolve naturally in the environment, long before the development and widespread use of modern medicines. “Studying microbes such as Psychrobacter SC65A.3 retrieved from millennia-old cave ice deposits reveals how antibiotic resistance evolved naturally,” Purcarea said.
While antimicrobial resistance is a natural phenomenon, scientists warn that its spread has accelerated significantly due to prolonged and widespread antibiotic use in human and veterinary medicine.
Antimicrobial resistance is a growing global health concern. The European Centre for Disease Prevention and Control has estimated that more than 35,000 deaths occur annually in Europe due to drug-resistant infections. The number is expected to rise as populations age and resistant pathogens spread across borders. Overuse and misuse of antibiotics, along with gaps in infection control, have contributed to the problem.
According to the World Health Organization, one in six bacterial infections worldwide is now resistant to standard treatments.
Researchers say that understanding cold-adapted microbes is increasingly important, particularly as climate change affects frozen environments that cover roughly one-fifth of the Earth’s surface.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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