Health
Over 100 Researchers Urge Safeguards on High-Risk Biological Data Amid AI Concerns
More than 100 scientists from leading institutions have called for stronger safeguards on sensitive biological datasets to prevent artificial intelligence (AI) from being misused to create dangerous pathogens. The open letter, signed by researchers from Johns Hopkins University, the University of Oxford, Fordham University, and Stanford University, highlights the potential biosecurity risks posed by unrestricted access to certain genetic and pathogen data.
AI models for biology rely heavily on large volumes of data, including genetic sequences and characteristics of viruses and other pathogens. While open access to such information has accelerated scientific discovery, the researchers warn that certain datasets could allow AI systems to design or enhance deadly viruses.
“The stakes of biological data governance are high, as AI models could help create severe biological threats,” the authors wrote. They describe the ability of AI to predict mutations, identify patterns, and generate more transmissible pathogen variants as a “capability of concern” that could speed up the development of biological threats affecting humans, animals, plants, or the environment.
The scientists stress that while most biological data should remain openly accessible, “concerning pathogen data” requires stricter security checks. The letter proposes a framework to define and govern high-risk datasets before they are generally available to AI developers. “Limiting access to sensitive pathogen data to legitimate researchers might be one of the most promising avenues for risk reduction,” said Moritz Hanke, co-author from Johns Hopkins University.
Currently, no universal rules govern access to these datasets. Some AI developers voluntarily exclude high-risk data from training, but approaches vary. Developers of AI models such as Evo, created by the Arc Institute, Stanford, and TogetherAI, and ESM3, from EvolutionaryScale, have withheld certain viral sequences to prevent potential misuse. In February 2025, the EVO 2 team announced that it had excluded pathogens infecting humans and complex organisms to reduce ethical and safety risks and prevent its use in bioweapon development.
The proposed framework introduces a five-tier system, called Biosecurity Data Levels (BDL), to classify pathogen data based on risk:
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BDL-0: Everyday biology data with no restrictions.
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BDL-1: Basic viral building blocks; monitored access recommended.
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BDL-2: Animal virus traits, such as species-jumping ability.
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BDL-3: Human virus characteristics, including transmissibility and vaccine resistance.
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BDL-4: Enhanced human viruses with potentially higher contagion, subject to the strictest controls.
To ensure safe access, the letter recommends technical tools including watermarking datasets to track leaks, audit logs with tamper-proof signatures, data provenance tracking, and behavioural biometrics to verify legitimate users.
The authors emphasize that balancing openness with security will be essential as AI systems grow more powerful. Without clear rules, frontier developers are left to make subjective decisions about what constitutes risky data, creating potential gaps in biosecurity.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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