Health
Over 100 Researchers Urge Safeguards on High-Risk Biological Data Amid AI Concerns
More than 100 scientists from leading institutions have called for stronger safeguards on sensitive biological datasets to prevent artificial intelligence (AI) from being misused to create dangerous pathogens. The open letter, signed by researchers from Johns Hopkins University, the University of Oxford, Fordham University, and Stanford University, highlights the potential biosecurity risks posed by unrestricted access to certain genetic and pathogen data.
AI models for biology rely heavily on large volumes of data, including genetic sequences and characteristics of viruses and other pathogens. While open access to such information has accelerated scientific discovery, the researchers warn that certain datasets could allow AI systems to design or enhance deadly viruses.
“The stakes of biological data governance are high, as AI models could help create severe biological threats,” the authors wrote. They describe the ability of AI to predict mutations, identify patterns, and generate more transmissible pathogen variants as a “capability of concern” that could speed up the development of biological threats affecting humans, animals, plants, or the environment.
The scientists stress that while most biological data should remain openly accessible, “concerning pathogen data” requires stricter security checks. The letter proposes a framework to define and govern high-risk datasets before they are generally available to AI developers. “Limiting access to sensitive pathogen data to legitimate researchers might be one of the most promising avenues for risk reduction,” said Moritz Hanke, co-author from Johns Hopkins University.
Currently, no universal rules govern access to these datasets. Some AI developers voluntarily exclude high-risk data from training, but approaches vary. Developers of AI models such as Evo, created by the Arc Institute, Stanford, and TogetherAI, and ESM3, from EvolutionaryScale, have withheld certain viral sequences to prevent potential misuse. In February 2025, the EVO 2 team announced that it had excluded pathogens infecting humans and complex organisms to reduce ethical and safety risks and prevent its use in bioweapon development.
The proposed framework introduces a five-tier system, called Biosecurity Data Levels (BDL), to classify pathogen data based on risk:
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BDL-0: Everyday biology data with no restrictions.
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BDL-1: Basic viral building blocks; monitored access recommended.
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BDL-2: Animal virus traits, such as species-jumping ability.
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BDL-3: Human virus characteristics, including transmissibility and vaccine resistance.
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BDL-4: Enhanced human viruses with potentially higher contagion, subject to the strictest controls.
To ensure safe access, the letter recommends technical tools including watermarking datasets to track leaks, audit logs with tamper-proof signatures, data provenance tracking, and behavioural biometrics to verify legitimate users.
The authors emphasize that balancing openness with security will be essential as AI systems grow more powerful. Without clear rules, frontier developers are left to make subjective decisions about what constitutes risky data, creating potential gaps in biosecurity.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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