Health
Overdiagnosis of Prostate Cancer May Explain Wide Variations in Incidence Across Europe, Study Finds
A new study published in the British Medical Journal has revealed that overdiagnosis of prostate cancer in Europe could be contributing to significant differences in cancer incidence rates across countries. While incidence rates varied up to 20-fold between nations, mortality rates only fluctuated by about five times, highlighting a potential disparity in how the disease is being diagnosed and treated.
Overdiagnosis occurs when a tumour is detected that would not have caused symptoms or death during an individual’s lifetime, leading to unnecessary treatments that may negatively impact a patient’s quality of life. The study suggests that widespread use of PSA (prostate-specific antigen) testing, particularly through opportunistic screening, may be driving overdiagnosis.
“The results of this study are compatible with large overdiagnosis of prostate cancer occurring as a consequence of opportunistic screening with PSA testing,” said Dr. Salvatore Vaccarella, the study’s lead author and a scientist at the International Agency for Research on Cancer (IARC).
Prostate cancer is a significant health issue in Europe, representing nearly a quarter of new cancer cases among men in 2020, with over 70,000 deaths attributed to the disease that year. The risk of overdiagnosis and subsequent overtreatment is higher for prostate cancer than for other cancers, such as breast, cervical, or colorectal, the study noted.
Most European countries, except Lithuania, which has implemented a wide screening programme since 2006, rely on individual-based decisions for PSA testing rather than population-wide screening. However, the study warned that PSA testing as part of routine healthcare or opportunistic screening is not optimal for reducing population-level impacts.
A 2009 study found that 23% to 42% of men diagnosed through PSA testing would have lived without ever knowing they had prostate cancer, further raising concerns about the screening method. The researchers emphasized that any future implementation of prostate cancer screening must be carefully designed to reduce the harms of overdiagnosis.
“The results of this new study emphasize the importance of carefully designing prostate cancer screening to minimize overdiagnosis, with proper quality assurance and monitoring,” Vaccarella added.
The findings were based on an analysis of data collected from 1980 to 2017 from men aged 35 to 84 across 26 European countries. However, the researchers cautioned that the observational nature of the study means no direct conclusions about cause and effect can be drawn.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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