Health
WHO Member States Approve Landmark Global Pandemic Treaty
The World Health Organization (WHO) on Tuesday formally adopted a legally binding pandemic treaty aimed at strengthening global preparedness and response to future health crises. The move marks a milestone in efforts to avoid repeating the mistakes made during the COVID-19 pandemic.
The treaty was approved by a majority of WHO member states at the organisation’s annual assembly in Geneva, despite a last-minute procedural challenge from Slovakia, which called for an early vote and later abstained. Poland, Italy, and eight other countries also abstained, but the overall agreement received broad support.
“This agreement will ensure countries work better, faster, and more equitably together to prevent and respond to the next pandemic threat,” said WHO Director-General Dr. Tedros Adhanom Ghebreyesus following the vote.
While the treaty is legally binding, it will not come into effect immediately. Several key elements, including the development of a proposed Pathogen Access and Benefit-Sharing (PABS) system, remain under negotiation. The PABS system would establish a framework for countries to share pathogen samples and related data with pharmaceutical companies in exchange for guaranteed access to vaccines and treatments.
Member states have agreed to finalise the remaining details within the next year. Once negotiations are completed, countries will be required to sign and ratify the treaty domestically. It will formally enter into force once 60 ratifications are secured.
French President Emmanuel Macron welcomed the agreement, urging nations to act swiftly. “We need to act as quickly as possible, yes, but we also need to spread the innovations we’ve made more quickly,” Macron told the assembly. “It’s not a question of if we will have a new pandemic, it’s a question of when.”
While the treaty is a major step forward in international health cooperation, concerns remain over its global reach. The United States, under a potential Trump administration, is not expected to ratify the accord, raising questions about its full effectiveness.
Germany’s Health Minister Nina Warken praised the progress made, highlighting the treaty as a positive development following the U.S.’s previous withdrawal from the WHO. She urged the organisation to continue its reforms and maintain focus on its core responsibilities: global health surveillance, pandemic prevention, and equitable access to healthcare.
The treaty sets the stage for a more coordinated global approach to health emergencies, with a focus on fairness, speed, and shared scientific innovation. However, the final shape of the agreement—and its long-term impact—will depend on continued international cooperation in the year ahead.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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