Health
U.S. Foreign Aid Freeze Sparks HIV Crisis as Millions Risk Losing Treatment
The global fight against HIV/AIDS is at risk as confusion over U.S. foreign aid policy threatens access to life-saving medication for millions. A temporary waiver for the President’s Emergency Plan for AIDS Relief (PEPFAR)—a program credited with saving countless lives—has left uncertainty in its wake, raising concerns about a resurgence in AIDS-related deaths.
According to the United Nations AIDS agency, the disruption could lead to 6.3 million AIDS-related deaths over the next five years. The crisis unfolds at a time when complacency around HIV is rising, with declining condom use among young people and the emergence of preventive drugs that some believe could end AIDS for good.
The Importance of PEPFAR
Launched in 2003, PEPFAR is widely considered one of the most successful foreign aid programs in history, providing antiretroviral drugs to millions of people worldwide. However, the Trump administration’s decision to freeze foreign aid, citing concerns over wasteful spending, has thrown the program into chaos.
Hundreds of U.S.-funded health workers in Africa—including in Kenya and Ethiopia—have already been laid off, causing significant disruptions to HIV testing, care, and support. Some clinics have reportedly turned patients away, leaving them without critical medication.
The U.S. Centers for Disease Control and Prevention (CDC) stresses that without HIV treatment, people with AIDS typically survive only three years. The fear now is that delays in resolving PEPFAR’s funding status could undo decades of progress in combating the epidemic.
What Happens When HIV Treatment Stops?
HIV, which is transmitted through blood, breast milk, or semen, weakens the immune system, making individuals vulnerable to life-threatening infections. The 1980s AIDS epidemic first alerted the world to this phenomenon when rare diseases began appearing in otherwise healthy people.
Today, antiretroviral drugs keep HIV from multiplying in the body. Stopping treatment allows the virus to rebound within weeks, raising the risk of transmission and potentially leading to drug-resistant strains.
For pregnant women, continued treatment is critical to preventing mother-to-child transmission. Without medication, babies born to HIV-positive mothers face a high risk of infection, which can lead to severe complications and early mortality.
Without treatment, people living with HIV become susceptible to opportunistic infections such as pneumonia, tuberculosis (TB), and salmonella—diseases that can be deadly when the immune system is compromised. In countries like South Africa, which has the highest number of HIV cases and a severe TB crisis, the effects of treatment disruptions could be catastrophic.
The Urgency of Action
For years, people living with HIV have been advised to take their medication at the same time every day to prevent viral resistance. Now, that routine is in jeopardy as supply chains break down.
Health experts warn that the longer PEPFAR’s future remains uncertain, the more people will be left without life-saving drugs. Restoring lost funding, rehiring laid-off workers, and rebuilding essential health programs will take time—time that millions of people may not have.
As the international community looks to the U.S. for clarity, the fate of millions of HIV patients hangs in the balance.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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