Health
Study Links PFAS Exposure to Gut Microbiome Issues and Kidney Damage in Young Adults
LOS ANGELES — New research suggests that exposure to per- and polyfluoroalkyl substances (PFAS), commonly referred to as “forever chemicals,” may contribute to disruptions in the gut microbiome that could, in turn, lead to kidney damage in young adults. This study adds to mounting concerns about the health impacts of these persistent chemicals.
PFAS, a group of synthetic chemicals, are widely used in a variety of everyday products, including food packaging, non-stick cookware, and water-resistant fabrics. Known as “forever chemicals” for their resilience, PFAS are nearly indestructible in nature and in the human body. As a result, they accumulate over time, becoming a near-universal presence in blood samples worldwide.
“Nearly everyone has PFAS in their blood, and these chemicals are linked to a range of negative health effects. But without interventions to remove PFAS from the body, there are no actionable recommendations to reduce exposure effects,” said Dr. Hailey Hampson, lead author and postdoctoral fellow at the Keck School of Medicine, in a statement.
Previous studies have associated PFAS exposure with a range of health issues, including liver damage, thyroid disorders, obesity, reproductive issues, and various cancers. This latest study highlights kidney disease as another potential consequence of exposure, focusing specifically on how changes in gut microbiome health may drive kidney damage in young adults.
In the study, researchers examined data from a cohort of 78 young adults, primarily Hispanic, aged 17 to 22, who are at higher risk of chronic kidney disease. Blood and stool samples collected from participants helped researchers measure PFAS levels, assess gut microbiome composition, and analyze metabolites circulating in their bodies. Four years later, the team reassessed the participants’ kidney function to evaluate long-term effects.
Findings revealed that participants with higher PFAS exposure experienced worse kidney function over time. The researchers linked this effect to changes in the gut microbiome, where PFAS exposure seemed to reduce anti-inflammatory metabolites and the bacteria responsible for producing them, while promoting inflammatory metabolites. The researchers found that these disruptions in gut health contributed to up to 50% of the decline in kidney function observed in the high-exposure group.
“These findings are an important piece of the puzzle about the many different health risks of PFAS,” said Dr. Jesse Goodrich, senior author of the study, which was published in Science of the Total Environment. “This information can help policymakers develop protections against exposure to these chemicals.”
While the sample size was limited, researchers emphasized the potential of their findings to guide future public health policies. As public awareness of PFAS contamination grows, the study offers early insights that may inform strategies to mitigate exposure and protect vulnerable populations.
The research team hopes that these insights will add to the growing body of evidence necessary for establishing regulations around PFAS, which remain ubiquitous in modern society despite their risks to human health.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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