Health
NHS Rolls Out New Anti-Smoking Drug to Boost Quit Rates Amid Push for a Smoke-Free UK
England’s National Health Service (NHS) has reintroduced an enhanced anti-smoking drug, Varenicline, aimed at increasing success rates for those seeking to quit smoking. Marketed as a prescription-only treatment, Varenicline offers an effective alternative to nicotine-replacement therapies like gum or patches and is comparable to vaping in its ability to curb smoking habits, according to NHS England.
The drug, taken daily, is reported to both reduce nicotine cravings and block the pleasurable effects of smoking on the brain. By minimizing withdrawal symptoms such as irritability and insomnia, Varenicline is seen as a promising tool in the NHS’s suite of smoking cessation options. When paired with counseling or other psychotherapeutic support, NHS data suggests that around 25% of users successfully quit smoking for six months or longer.
The reintroduction of Varenicline is expected to have a substantial public health impact. Research from University College London (UCL) indicates that the drug could assist more than 85,000 people in quitting smoking each year and could prevent up to 9,500 smoking-related deaths over the next five years.
“Prevention is better than cure,” said Wes Streeting, the UK’s Health and Social Care Secretary, in a statement regarding the drug’s rollout. “The availability of this pill can save the NHS millions, speed up appointment availability for other patients, and save lives.”
Previously available under the brand name Champix, Varenicline was withdrawn from NHS prescriptions in 2021 due to the detection of an impurity. However, the newly launched version has been approved by the Medicines and Healthcare Products Regulatory Agency (MHRA), confirming its safety and efficacy.
NHS Chief Executive Amanda Pritchard emphasized Varenicline’s role in the NHS’s preventive healthcare focus during a speech at the NHS Providers annual conference. “This simple daily pill could be a game-changer for those looking to quit smoking and marks another significant step toward prevention,” she said. “Smoking remains one of the biggest public health issues, impacting the lungs, heart, blood, and brain, and increasing the risk of serious conditions such as cancer and diabetes.”
The launch of Varenicline aligns with the UK’s broader anti-smoking goals, which include a proposed bill to prevent individuals born after January 1, 2009, from legally purchasing cigarettes. Currently, about 12% of adults in the UK smoke, a figure that correlates with over 400,000 smoking-related hospital admissions in England from 2022 to 2023.
The NHS already offers various smoking cessation options, including nicotine replacement therapies and the antidepressant Bupropion (Zyban), which has been shown to reduce cravings. While vaping is also commonly used, it remains unavailable through NHS prescriptions. The National Institute for Health and Care Excellence (NICE) instead recommends licensed stop-smoking medications like Varenicline.
Professor Nick Hopkinson, a respiratory medicine expert at Imperial College London, described Varenicline as “the most effective smoking cessation medication” and emphasized that pairing it with counseling support can improve quit success rates. Dr. Sarah Jackson, principal research fellow at the UCL Tobacco and Alcohol Research Group, added that Varenicline’s availability “can help more people avoid years of ill health and early death.”
With the NHS spending £2.5 billion annually on smoking-related health issues, the reintroduction of Varenicline is viewed as a cost-saving initiative with the potential to improve public health outcomes significantly. As the UK continues its push towards becoming smoke-free, Varenicline offers a new hope for smokers looking to quit and contribute to the nation’s ambitious health goals.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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