Health
New Study Warns Tattoo Ink May Influence Immune Response and Disease Resistance
A major scientific study has raised fresh concerns about the impact of tattoo inks on the body’s immune system, suggesting that the pigments used to create tattoo designs may interfere with how the body responds to disease and vaccination.
Researchers at the Institute for Research in Biomedicine at the Università della Svizzera italiana (USI) examined the toxicity of pigments used in the three most common tattoo colours: black, red and green. The study, published in the journal PNAS, is being described by the team as the most extensive investigation yet into how tattoo inks interact with immune cells.
The scientists found that pigment does not remain confined to the skin. Instead, particles travel through the body and collect in immune tissues, where they can persist for years. Once inside these tissues, the ink triggers cell damage. Macrophages — immune cells responsible for clearing foreign substances — are unable to break down the pigment, leading to swelling and prolonged strain on the immune system.
Pigments used in red and black tattoos caused the strongest reactions in laboratory tests.
When the researchers examined tattooed mice, they recorded rapid movement of pigment to the lymph nodes, where it continued to accumulate for at least two months. The altered immune activity appeared to affect how the animals responded to vaccines. In tests, the mice showed a weaker response to COVID-19 vaccines after tattooing, although the same pigments appeared to strengthen the response to a UV-inactivated flu vaccine.
Scientists stressed that more work is needed to confirm these findings in humans and across a wider range of vaccines. The International Agency for Research on Cancer (IARC) is conducting separate research into possible long-term risks, including links between tattoo pigments, the immune system, and cancers such as lymphomas.
Researchers note that many pigment particles are extremely small, allowing them to circulate beyond the dermis, the layer of skin where tattoos are placed. This raises the possibility that exposure is not limited to the area of the tattoo.
Tattooing has become increasingly common, especially in Europe and the United States, where up to 40 percent of adults under 40 have at least one tattoo. IARC has said that the growth of the tattoo industry has turned pigment safety into a rising public health concern.
Tattoo ink can contain up to 100 chemical substances. Black ink usually contains carbon-based pigments, while coloured designs often rely on industrial pigments originally meant for plastics or paints. Europe introduced new rules in 2022 under its REACH chemical safety regulation to bring stricter oversight to ingredients used in tattoo inks.
With tattoo popularity rising worldwide, scientists say understanding these biological effects is becoming increasingly important.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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