Health

EU Food Safety Agency Lowers Safe Fluoride Intake Amid Concerns Over Children’s Brain Development

Published

12 months ago

July 23, 2025

The European Food Safety Authority (EFSA) has issued new guidance lowering the safe daily intake of fluoride, amid growing concerns that even low levels of exposure may impact children’s brain development.

In a comprehensive reassessment, EFSA said there is currently no strong evidence of serious health risks from fluoride at levels typically found in EU drinking water. However, the agency acknowledged that new scientific findings suggest possible links between fluoride exposure and lower IQ in children, prompting it to lower recommended safety thresholds.

Fluoride is a naturally occurring mineral widely known for its role in preventing tooth decay. While only a few European countries, including Ireland and parts of Spain, actively add fluoride to public water supplies, the substance is present in roughly 90% of toothpaste brands. Most EU drinking water contains fluoride concentrations below 0.3 milligrams per litre (mg/L), well within the bloc’s legal limit of 1.5 mg/L and the same maximum recommended by the World Health Organization (WHO).

Despite these low levels, EFSA’s new review—which analyzed over 20,000 scientific studies—raises fresh questions. Experts reviewed fluoride’s potential effects on the developing brain, bones, thyroid function, and dental health through common sources such as water, food, fluoridated salt, and dental care products.

“We estimated that, in general, with the current concentrations of fluoride in European drinking water, total fluoride exposure does not pose a health concern,” said EFSA toxicologist Susanne Hougaard Bennekou. However, she noted that children aged four to eight who regularly swallow toothpaste could face mild tooth discoloration, particularly in their developing molars. “This is unlikely to occur if children spit the toothpaste out properly after brushing,” she added.

In response to the findings, EFSA introduced new safe daily intake thresholds:

1 mg/day for infants under one year
1.6 mg/day for toddlers aged one to three
2 mg/day for children aged four to eight
3.3 mg/day for older children and adults, including pregnant women

These new recommendations aim to protect against potential risks to brain development, thyroid function, and bone health. While they currently serve as part of a consumer safety guideline, they may influence future revisions to EU regulations on fluoride in drinking water.

Still, experts say more research is needed. “There is evidence that we can’t ignore linking fluoride to possible effects on the developing nervous system of the foetus,” said Thorhallur Halldorsson, chair of EFSA’s working group on fluoride. “But the evidence is not yet strong enough to set a definitive threshold.”

The findings could renew debate across Europe on the use of fluoride in public health, especially as governments weigh the benefits of dental protection against emerging concerns over long-term neurological effects.

Health

Study Finds Men Far More Likely Than Women to ‘Hit the Wall’ in Marathons

Published

2 days ago

July 4, 2026

Web Reporter

Men are significantly more likely than women to experience the dreaded marathon phenomenon known as “hitting the wall,” according to a large international study that analysed the performances of more than 870,000 runners over a 26-year period.

The research, published in the journal Scientific Reports, examined the results of 873,334 finishers in the Berlin Marathon between 1999 and 2025. Researchers found that although men generally complete marathons faster than women, they are much more likely to suffer a dramatic slowdown during the later stages of the race because of less consistent pacing.

According to the study, men are almost twice as likely overall to experience a sudden decline in speed during a marathon. In some performance categories, they were found to be up to six times more likely than women to “hit the wall,” a term commonly used to describe severe physical exhaustion caused by depleted energy stores.

Researchers said the findings point to differences in race strategy rather than physical ability alone. Men were more likely to begin races at an aggressive pace, increasing the risk of fatigue before reaching the finish line.

The study concluded that “men, regardless of performance level, are more prone to aggressive pacing and catastrophic deceleration.” The authors suggested that greater willingness to take risks and higher levels of confidence may encourage many male runners to start faster than they can realistically sustain over the full 42.195-kilometre distance.

Women, on the other hand, displayed more controlled pacing throughout the race. Researchers found they were better at regulating their effort from start to finish, reducing the likelihood of a significant loss of speed during the closing kilometres.

The report described women as showing “superior self-pacing abilities and greater resistance to decision-making fatigue,” characteristics that can be particularly valuable during endurance events.

Maintaining a steady pace is widely regarded as one of the most important factors in marathon performance. Running too quickly during the opening stages can rapidly consume the body’s glycogen reserves, leaving athletes without enough energy to sustain their speed in the final part of the race.

The researchers noted that pacing is “the most critical tactical determinant of performance” in marathon running, making strategic decision-making just as important as physical fitness.

The findings could influence how coaches and runners prepare for long-distance races. Rather than focusing solely on speed, the study suggests that adopting a realistic race plan and maintaining a consistent pace throughout the event may improve overall performance and reduce the chances of a late-race collapse.

With marathon participation continuing to grow worldwide, the researchers believe a better understanding of pacing strategies could help runners of all abilities achieve stronger and more consistent results.

Health

Study Links Higher Coffee Consumption to Lower Risk of Liver Disease

Published

3 days ago

July 3, 2026

Web Reporter

Regular coffee consumption may help reduce the risk of serious liver diseases, including cirrhosis, liver cancer and liver-related deaths, according to a new study published in the journal Clinical Gastroenterology and Hepatology.

The research found that people who consumed higher amounts of coffee, including decaffeinated varieties, were less likely to develop chronic liver conditions than those who drank little or no coffee. The findings add to growing evidence that coffee may play a role in supporting long-term liver health, although researchers stressed that the results do not prove a direct cause-and-effect relationship.

The study examined data from more than 350,000 participants enrolled in the UK Biobank, one of the world’s largest long-term health research projects. None of the participants had cirrhosis or liver cancer at the beginning of the study. Researchers monitored their health over a period of 13 years to assess how coffee consumption affected liver-related outcomes.

According to the findings, participants who drank five or more cups of coffee each day had a 32 percent lower risk of developing cirrhosis than those who consumed little or no coffee. They also recorded a 47 percent lower risk of liver cancer and a 42 percent reduction in deaths linked to liver disease.

Researchers found additional indicators of improved liver health among regular coffee drinkers. Participants with higher coffee intake showed lower levels of liver fat, liver iron, fibrosis and inflammation. Blood tests also revealed increased levels of proteins associated with healthy liver function, while markers linked to liver scarring and inflammation were generally lower.

The findings come as liver disease continues to pose a major global health challenge. A separate study published in 2023 estimated that liver disease causes around two million deaths each year, accounting for about four percent of all deaths worldwide. Men account for nearly two-thirds of those fatalities.

Despite the encouraging results, the researchers urged caution in interpreting the findings. Senior study author Ju Dong Yang said moderate coffee consumption appears to be beneficial for people who already enjoy drinking coffee and tolerate it well.

“Our findings support moderate coffee consumption for people who already enjoy and tolerate it well,” Yang said.

He added that the study does not provide sufficient evidence to recommend that people who do not currently drink coffee should begin doing so solely to reduce their risk of liver disease.

Health experts continue to advise that maintaining a healthy weight, limiting alcohol consumption, eating a balanced diet and managing conditions such as obesity and diabetes remain the most effective ways to reduce the risk of chronic liver disease. Researchers said additional studies are needed to better understand which compounds in coffee may contribute to its potential protective effects.

Health

Lancet Review Finds mRNA Vaccines Safe and Highly Effective, Calls for Wider Global Access

Published

5 days ago

July 1, 2026

Web Reporter

A comprehensive review of data covering billions of administered doses of mRNA vaccines has concluded that the technology remains both safe and highly effective in preventing infectious diseases, with researchers urging governments and health organisations to focus on expanding global access.

The review, published in The Lancet, examined evidence gathered since mRNA vaccines were first deployed on a large scale during the COVID-19 pandemic. Researchers found that the vaccines continue to provide strong protection against severe illness while serious side effects remain uncommon.

Unlike conventional vaccines, mRNA vaccines work by delivering genetic instructions that enable the body’s cells to produce a harmless viral protein. This process trains the immune system to recognise and respond to future infections without altering a person’s DNA.

According to the review, mRNA vaccines were 87% effective in preventing confirmed SARS-CoV-2 infections within 14 to 42 days after vaccination. The vaccines also demonstrated 93% effectiveness in preventing hospital admissions and 94% effectiveness in preventing deaths related to COVID-19 during the same period.

Researchers noted that immunity declines over time, but booster doses restore a significant portion of the lost protection.

The review also assessed vaccine safety across billions of administered doses. It found that serious adverse events, including myocarditis, pericarditis and anaphylaxis, occurred very rarely. Most reported reactions, such as pain at the injection site, fatigue and fever, were mild to moderate and typically resolved within a few days.

“Across billions of administered doses, serious adverse events have been rare, well characterised, and consistently outweighed by the substantial protection conferred against severe disease, hospitalisation, and death,” the researchers wrote.

The review concluded that the vaccines have proven effective across a broad range of populations, including children, older adults, pregnant women and people with weakened immune systems.

Researchers also highlighted the growing potential of mRNA technology beyond infectious diseases. They said ongoing research could lead to personalised cancer vaccines designed to match an individual patient’s tumour characteristics, opening new possibilities for targeted treatment.

Co-author Manish Sadarangani of the University of British Columbia and BC Children’s Hospital Research Institute said mRNA vaccines have already changed how the world responds to emerging infectious diseases and could continue to play an important role in preventive medicine and cancer care.

The review also noted that improvements in vaccine storage, including higher-temperature storage methods and freeze-drying technologies, could simplify transportation, reduce waste and improve access in remote regions.

Despite these advances, the researchers stressed that manufacturing capacity and equitable distribution remain major challenges. They called for greater investment in local production, technology transfer and stronger regulatory systems, particularly in low- and middle-income countries.

Co-author Robin Shattock of Imperial College London said expanding manufacturing networks and strengthening regional production capabilities would shorten supply chains, lower costs and help ensure countries have faster access to vaccines during future global health emergencies.