Health
AI Tool Could Help Target Prostate Cancer Treatment, Improve Patient Outcomes
A new artificial intelligence (AI) tool could significantly improve outcomes for prostate cancer patients by identifying who would benefit most from the drug abiraterone, according to UK researchers presenting their findings at the American Society of Clinical Oncology’s annual meeting this week.
The tool analyzes tumour biopsy images to detect hidden biomarkers that predict whether a patient is likely to respond well to abiraterone, a drug known to nearly halve the risk of death for some men with prostate cancer. While effective, abiraterone is expensive and carries potential side effects such as high blood pressure, liver issues, and diabetes. These concerns have led health systems to prescribe it cautiously.
“This research shows that we can pick out the people who will respond best to abiraterone, and those who will do well from standard treatment alone – hormone therapy and radiotherapy,” said Professor Nick James, co-lead of the study from the UK’s Institute of Cancer Research.
The AI model was developed by studying tumour pathology slides and identifying molecular markers invisible to the human eye. Researchers then applied the tool to biopsy images from over 1,000 men enrolled in an earlier clinical trial on prostate cancer therapies.
Among patients whose tumours tested positive for the biomarker, abiraterone cut the five-year mortality rate from 17% to 9%. In contrast, those without the biomarker did not show a significant benefit from the drug, suggesting they could avoid unnecessary side effects and rely on standard treatments instead.
“This study shows, in a very large cohort of patients, that novel algorithms can be used to extract information from routinely available pathology slides to tailor these treatments to specific patients and minimise over-treatment whilst maximising the chance of cure,” said Professor Gert Attard of the University College London Cancer Institute, the study’s co-lead.
In the UK, access to abiraterone varies. While it is approved for use in newly diagnosed high-risk patients in Scotland and Wales, England’s NHS only offers the drug once the cancer has spread. The researchers called for policy changes, estimating that up to 8,400 men in England could benefit from earlier access.
“Access to this life-extending drug is currently a postcode lottery,” James said. “Those living in Scotland and Wales can receive the treatment for free — others cannot.”
Prostate cancer remains one of the most common cancers among men, with nearly 336,000 new cases diagnosed annually in the European Union.
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Irregular Sleep Patterns Linked to Higher Anxiety Risk Among Teenagers
Teenagers who regularly change their sleeping patterns between weekdays and weekends may face a greater risk of anxiety, according to a new study from researchers at the University of Southampton in the United Kingdom.
The findings come as students return to school after the summer break, when many adolescents may have become accustomed to later nights and longer mornings. The shift back to early school schedules can create a mismatch between weekday and weekend sleep patterns, a phenomenon researchers describe as “social jet lag.”
A review of 12 studies involving more than 230,000 participants found that teenagers experiencing greater levels of social jet lag were more likely to report higher levels of anxiety. The relationship also appeared to work in the opposite direction, with higher anxiety associated with greater disruption to sleep schedules.
However, researchers stressed that the findings show an association rather than proving that irregular sleep directly causes anxiety.
The study highlights the importance of encouraging healthy and consistent sleeping habits as part of efforts to support adolescent mental health. Anxiety is already one of the most common mental health problems among young people.
The World Health Organization estimates that anxiety disorders affect about 4.4% of children aged 10 to 14 and 5.5% of those aged 15 to 19 worldwide. Such disorders involve persistent fear or nervousness that can be difficult to control.
Researchers say adolescence is a particularly important period for sleep because biological changes naturally alter young people’s body clocks.
Sarah Chellappa, a co-author of the study from the University of Southampton, said teenagers generally experience a shift toward later sleep during puberty.
“During puberty, the body’s internal clock usually shifts back by a few hours,” she said, meaning teenagers naturally become sleepy later and may need to wake later as well.
Early school starts can conflict with this biological change. Social activities, online communication and other demands can also reduce the amount of sleep teenagers get during the week.
Hannah Ravenhall, lead author of the study, said the issue should not be viewed solely as a matter of individual responsibility.
She said broader social systems can influence young people’s sleep and called for greater recognition of the biological changes that occur during adolescence.
The researchers suggested that schools could consider whether their start times adequately reflect teenagers’ changing sleep needs. Parents could also review evening routines, including rules around screen use.
Rather than simply encouraging teenagers to go to bed earlier, the researchers argue that more consistent schedules and changes to the environments in which young people live and study could help support better sleep and mental wellbeing.
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