Health
AI Tool Could Help Target Prostate Cancer Treatment, Improve Patient Outcomes
A new artificial intelligence (AI) tool could significantly improve outcomes for prostate cancer patients by identifying who would benefit most from the drug abiraterone, according to UK researchers presenting their findings at the American Society of Clinical Oncology’s annual meeting this week.
The tool analyzes tumour biopsy images to detect hidden biomarkers that predict whether a patient is likely to respond well to abiraterone, a drug known to nearly halve the risk of death for some men with prostate cancer. While effective, abiraterone is expensive and carries potential side effects such as high blood pressure, liver issues, and diabetes. These concerns have led health systems to prescribe it cautiously.
“This research shows that we can pick out the people who will respond best to abiraterone, and those who will do well from standard treatment alone – hormone therapy and radiotherapy,” said Professor Nick James, co-lead of the study from the UK’s Institute of Cancer Research.
The AI model was developed by studying tumour pathology slides and identifying molecular markers invisible to the human eye. Researchers then applied the tool to biopsy images from over 1,000 men enrolled in an earlier clinical trial on prostate cancer therapies.
Among patients whose tumours tested positive for the biomarker, abiraterone cut the five-year mortality rate from 17% to 9%. In contrast, those without the biomarker did not show a significant benefit from the drug, suggesting they could avoid unnecessary side effects and rely on standard treatments instead.
“This study shows, in a very large cohort of patients, that novel algorithms can be used to extract information from routinely available pathology slides to tailor these treatments to specific patients and minimise over-treatment whilst maximising the chance of cure,” said Professor Gert Attard of the University College London Cancer Institute, the study’s co-lead.
In the UK, access to abiraterone varies. While it is approved for use in newly diagnosed high-risk patients in Scotland and Wales, England’s NHS only offers the drug once the cancer has spread. The researchers called for policy changes, estimating that up to 8,400 men in England could benefit from earlier access.
“Access to this life-extending drug is currently a postcode lottery,” James said. “Those living in Scotland and Wales can receive the treatment for free — others cannot.”
Prostate cancer remains one of the most common cancers among men, with nearly 336,000 new cases diagnosed annually in the European Union.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
AI Models Show Ability to Mimic Human Emotions, Offering New Pathways for Mental Health Research
Health
AI Saves Clinicians Weeks of Work but Health Systems Struggle to Keep Up, Philips Report Finds
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