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Novo Nordisk Shares Plunge 20% After Disappointing CagriSema Trial Results

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Novo Nordisk experienced its sharpest one-day decline in history on Friday as shares of the Danish pharmaceutical giant plummeted 20% following underwhelming trial results for its new obesity drug, CagriSema. The drop wiped out €90 billion in market valuation, significantly impacting the year-to-date performance of Europe’s largest company, which is now down 16% in 2024.

CagriSema Misses Expectations

The phase 3 trial for CagriSema revealed a weight loss of 22.7% over 68 weeks, below the projected 25% benchmark. The figure fell further to 20.4% among patients who did not strictly adhere to the treatment regimen. The results raised concerns about Novo Nordisk’s competitiveness in the rapidly growing obesity and diabetes drug market.

Eli Lilly, Novo Nordisk’s primary U.S.-based rival, reported a 24% weight loss in September with its latest drug, retatrutide. Eli Lilly’s stock surged 10% before closing 1.35% higher on Friday and has gained 32% this year, a stark contrast to Novo Nordisk’s performance.

Adding to the disappointment, only 57% of CagriSema trial participants reached the highest dose, compared to 83% for cagrilintide and 70% for semaglutide in previous studies. Concerns about the drug’s side effects and market positioning have tempered investor expectations.

“Based on insights from the REDEFINE 1 trial, we will explore additional weight loss potential for CagriSema,” said Martin Holst Lange, Novo Nordisk’s executive vice president for Development. Results from a second phase 3 trial, REDEFINE 2, are expected in the first half of 2025.

Heightened Competition in the Weight-Loss Market

The global market for weight-loss and diabetes drugs, including GLP-1 treatments, is projected to grow to between $150 billion and $200 billion by 2030. Novo Nordisk’s weight-loss drug Wegovy and diabetes treatment Ozempic accounted for 61% of the company’s sales in the first nine months of 2024.

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Eli Lilly has emerged as a formidable competitor with its weight-loss drugs Zepbound and Mounjaro. The U.S.-based company, valued at $691 billion (€662 billion), has positioned itself as a market leader, with analysts expecting the two firms to evenly split the weight-loss market by the end of 2024.

Future Challenges for Novo Nordisk

Novo Nordisk faces mounting pressure to expedite next-generation drug development as the patent for Wegovy is set to expire in the early 2030s. The disappointing results for CagriSema have raised doubts about the company’s ability to sustain its dominance in the sector.

The U.S. remains Novo Nordisk’s largest market, accounting for 35% of its diabetes drug sales as of August 2024. While the company’s valuation peaked in June, Friday’s market reaction underscores the challenges it faces in retaining its competitive edge in a rapidly evolving industry.

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Fuel Prices Surge Across Europe as Middle East Crisis Pushes Oil Above $100

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Fuel prices across Europe have risen sharply in recent weeks following the escalation of tensions in the Middle East, with both petrol and diesel costs climbing significantly since late February.

The increase comes as Brent crude oil prices moved above $100 per barrel after a joint strike by the United States and Israel on Iran, triggering concerns about global energy supply. The rise in crude prices has quickly filtered down to consumers across European countries.

According to the European Commission, the average price of Euro-super 95 petrol in the European Union stood at €1.871 per litre at the end of March, while diesel reached €2.076 per litre. Compared to late February, petrol prices are about 15 percent higher, while diesel has surged by around 30 percent.

There are wide differences in fuel prices across EU member states. The Netherlands recorded the highest diesel prices at €2.46 per litre, followed by Denmark and Germany. Other countries with above-average diesel costs include Finland, Belgium, France and Ireland.

At the other end of the scale, Malta reported the lowest diesel price at €1.21 per litre, significantly below the EU average. Hungary, Slovenia and Bulgaria also ranked among the least expensive markets for diesel. In several countries including Spain, Slovakia and Croatia, diesel prices remained below €2 per litre.

Petrol prices show a similar pattern. The Netherlands again recorded the highest price at €2.33 per litre, with Denmark and Germany also among the most expensive. Greece and France reported petrol prices above €2 per litre as well.

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Malta had the lowest petrol price at €1.34 per litre, followed by Bulgaria. Other relatively cheaper markets included Slovenia, Hungary and Spain, where prices remained below €1.60 per litre.

The data also highlights the role of taxation in fuel pricing. Taxes account for a significant portion of costs across Europe, making up more than half of petrol prices and nearly 45 percent of diesel prices on average. The share varies by country, with Slovenia recording one of the highest tax proportions on petrol, while Bulgaria had one of the lowest.

Despite the shift toward cleaner energy, traditional fuels continue to dominate the European vehicle market. According to Eurostat, petrol-powered cars accounted for 66.6 percent of new registrations in 2024, followed by diesel vehicles at 16.9 percent and fully electric cars at 13.5 percent.

The latest rise in fuel costs underscores the continued sensitivity of European energy markets to geopolitical developments, with consumers facing increased expenses as global tensions persist.

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Oil Prices Surge as Strait of Hormuz Closure Shakes Markets

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The brief sigh of relief across global markets lasted barely a day. Brent crude climbed sharply back towards $100 a barrel on Thursday after Iran moved to close the Strait of Hormuz, sending a clear signal that the fragile Middle East ceasefire was already fracturing.

The global benchmark was trading at $98.61 a barrel in early afternoon dealings, up about 4 percent, after plunging as much as 16 percent the previous day to below $91. That earlier drop had been driven by optimism that a two-week pause in hostilities between the United States and Iran could ease tensions and stabilize energy flows.

Iran’s move to shut the strategic waterway followed Israeli airstrikes on Hezbollah targets in Lebanon, which Tehran described as a violation of the ceasefire. The Strait of Hormuz is a vital route for global energy supplies, carrying roughly a fifth of the world’s oil and gas. Its closure has raised immediate concerns among governments and businesses about supply disruptions and rising costs.

Sultan Al Jaber, chief executive of Abu Dhabi’s state oil company Adnoc, said Iran appeared to be using control of the strait as a political tool rather than ensuring free navigation. Analysts say such actions could deepen uncertainty for industries that rely heavily on stable energy supplies.

Nigel Green, chief executive of financial advisory firm deVere, warned that the situation leaves a significant share of global oil flows exposed to geopolitical risk. For small and medium-sized businesses already dealing with high energy costs, the renewed volatility adds further pressure.

Stock markets reacted negatively to the developments. The FTSE 100 fell 0.2 percent after posting strong gains the previous day, while Germany’s DAX dropped 1.4 percent and France’s CAC 40 declined 0.7 percent. In Asia, major indexes in Japan, South Korea, and China all closed lower.

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Wall Street, which had rallied strongly on Wednesday with the S&P 500 rising 2.5 percent and the Dow Jones Industrial Average gaining nearly 3 percent, was expected to open lower as investor confidence weakened.

US President Donald Trump said American forces would remain in the Gulf until a lasting agreement is secured and respected, warning of serious consequences if the situation deteriorates further.

Meanwhile, Israel intensified its military operations in Lebanon, carrying out its heaviest strikes since the conflict with the Iran-backed Hezbollah group escalated last month. Reports indicate that more than 250 people have been killed in the latest wave of attacks.

The renewed instability highlights the continued vulnerability of global energy markets to geopolitical tensions. With oil prices approaching $100 a barrel once again, businesses are facing renewed uncertainty, particularly in sectors such as manufacturing and logistics that are highly sensitive to fuel costs.

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Spain Employment Hits Record as Social Security Enrolment Tops 22 Million

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Spain’s labour market reached a historic milestone in March, with Social Security enrolment surpassing 22 million contributors for the first time, driven by seasonal hiring linked to Easter and continued growth in the services sector.

New data released on Monday showed that the number of contributors, adjusted for seasonal variations, rose to 22,010,532 after 80,274 jobs were added during the month. In average terms, employment increased by 211,510 people, marking the largest rise ever recorded for a March period.

Unadjusted figures also reflected a record level, with more than 21.8 million people registered with Social Security. The government highlighted that the number of contributors has grown by nearly 3.4 million since 2018, pointing to sustained expansion in the labour market.

Officials said the latest gains were supported by increased activity during Easter Week, which traditionally boosts employment in tourism, hospitality and other service-related industries. Growth has also been noted in higher-skilled sectors, including information technology, science and professional services.

The data showed that female employment continues to rise, nearing 10.4 million, while permanent contracts have increased as a share of overall employment. Authorities linked these trends to labour reforms introduced in recent years aimed at improving job stability and workforce participation.

Prime Minister Pedro Sánchez acknowledged the milestone in a brief social media message before later praising workers in a video statement. He said the achievement reflected the efforts of millions of people contributing to the country’s economic progress.

The labour market report also indicated a modest improvement in unemployment. The number of jobless people fell by 0.9 percent in March to 2.42 million, the lowest level recorded for the month since 2008. Over the past year, unemployment has declined by more than 160,000.

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Second Vice-President and Employment Minister Yolanda Díaz said that both female and youth unemployment have reached historic lows. She attributed the positive results to structural changes in the labour market and policies designed to support job creation and stability.

Economists note that while seasonal factors played a role in the March figures, the broader trend points to continued resilience in Spain’s economy. Strong demand in services and ongoing improvements in employment conditions have helped sustain growth despite external uncertainties.

The latest figures underline the strength of Spain’s recovery in recent years, with employment reaching new highs and unemployment continuing its gradual decline.

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