Business
Novo Nordisk Shares Plunge 20% After Disappointing CagriSema Trial Results
Novo Nordisk experienced its sharpest one-day decline in history on Friday as shares of the Danish pharmaceutical giant plummeted 20% following underwhelming trial results for its new obesity drug, CagriSema. The drop wiped out €90 billion in market valuation, significantly impacting the year-to-date performance of Europe’s largest company, which is now down 16% in 2024.
CagriSema Misses Expectations
The phase 3 trial for CagriSema revealed a weight loss of 22.7% over 68 weeks, below the projected 25% benchmark. The figure fell further to 20.4% among patients who did not strictly adhere to the treatment regimen. The results raised concerns about Novo Nordisk’s competitiveness in the rapidly growing obesity and diabetes drug market.
Eli Lilly, Novo Nordisk’s primary U.S.-based rival, reported a 24% weight loss in September with its latest drug, retatrutide. Eli Lilly’s stock surged 10% before closing 1.35% higher on Friday and has gained 32% this year, a stark contrast to Novo Nordisk’s performance.
Adding to the disappointment, only 57% of CagriSema trial participants reached the highest dose, compared to 83% for cagrilintide and 70% for semaglutide in previous studies. Concerns about the drug’s side effects and market positioning have tempered investor expectations.
“Based on insights from the REDEFINE 1 trial, we will explore additional weight loss potential for CagriSema,” said Martin Holst Lange, Novo Nordisk’s executive vice president for Development. Results from a second phase 3 trial, REDEFINE 2, are expected in the first half of 2025.
Heightened Competition in the Weight-Loss Market
The global market for weight-loss and diabetes drugs, including GLP-1 treatments, is projected to grow to between $150 billion and $200 billion by 2030. Novo Nordisk’s weight-loss drug Wegovy and diabetes treatment Ozempic accounted for 61% of the company’s sales in the first nine months of 2024.
Eli Lilly has emerged as a formidable competitor with its weight-loss drugs Zepbound and Mounjaro. The U.S.-based company, valued at $691 billion (€662 billion), has positioned itself as a market leader, with analysts expecting the two firms to evenly split the weight-loss market by the end of 2024.
Future Challenges for Novo Nordisk
Novo Nordisk faces mounting pressure to expedite next-generation drug development as the patent for Wegovy is set to expire in the early 2030s. The disappointing results for CagriSema have raised doubts about the company’s ability to sustain its dominance in the sector.
The U.S. remains Novo Nordisk’s largest market, accounting for 35% of its diabetes drug sales as of August 2024. While the company’s valuation peaked in June, Friday’s market reaction underscores the challenges it faces in retaining its competitive edge in a rapidly evolving industry.
Business
Consortium Agrees to All-Cash Deal to Acquire Polish Parcel Company InPost
A consortium of investors has reached an agreement to acquire all shares of Polish-founded parcel locker company InPost, betting on the growth of self-service delivery across Europe. The deal is structured as an all-cash public offer valued at €15.6 per share.
The consortium includes funds managed or advised by Advent International, FCWB LLC—a wholly owned subsidiary of FedEx Corporation—A&R Investments Ltd., and PPF Group, together with InPost itself. The agreement is conditional and recommended by the InPost board.
InPost is best known for its proprietary Paczkomat parcel machines, widely used across Poland. These white self-service lockers, often located in subway stations or local shops, allow customers to send and receive small and medium parcels independently, bypassing traditional courier methods.
“Together, we will strengthen our network and reach more consumers with enhanced fast and flexible delivery options as we continue our objective of redefining the European e-commerce sector,” said Rafał Brzoska, CEO and founder of InPost. Brzoska confirmed he will remain as chief executive, and the company’s headquarters, management team, and key innovation operations will continue to be based in Poland.
“Importantly, I remain fully committed to leading the InPost Group. Our headquarters, management team and key innovation capabilities will remain in Poland, which will continue to be the centre for implementing the group’s successful strategy,” Brzoska added.
InPost has been expanding its footprint internationally. In the UK, the company acquired a 95.5% stake in competitor Yodel last year. It also operates in Italy, France, Belgium, the Netherlands, Luxembourg, Spain, and Portugal, managing parcel deliveries for online vendors across multiple European markets.
Following the completion of the transaction, FedEx will become a shareholder in InPost, joining the other investors to guide the company’s growth strategy. Prior to the deal, InPost was owned by PPF Group, A&R Investments—funds controlled by Brzoska—and Advent International, with just over half of the shares held by other investors.
Analysts say the acquisition reflects the rising demand for self-service parcel solutions, particularly in Europe’s growing e-commerce sector. The all-cash nature of the deal underscores confidence in InPost’s operational model and its ability to scale across multiple countries.
InPost has built a reputation for innovation in last-mile delivery, offering convenient alternatives to home delivery and enabling retailers to meet the increasing expectations of online shoppers. The company’s continued expansion and strong market position in Poland and abroad make it a strategic target for investors seeking to capitalize on the shift toward automated parcel services.
With Brzoska remaining at the helm and the company’s operational base secure in Poland, InPost looks set to maintain its leadership in self-service delivery while leveraging the backing of global investors to expand further across Europe.
Business
Scandinavian Airlines Looks to AI and Consolidation for Growth Amid Industry Challenges
The airline’s chief says artificial intelligence will help rebuild schedules during storms and improve efficiency in an industry that faces constant uncertainty. Scandinavian Airlines (SAS) is preparing for a new phase of growth while awaiting regulatory approval for its integration into the Air France-KLM group, according to President and CEO Anko van der Werff.
Speaking at the World Governments Summit in Dubai, van der Werff acknowledged the delay in the regulatory process. “We expect to get regulatory approval in the second half of the year,” he said. “I’m always a bit impatient… it’s a slow process.” He emphasized that many initiatives are effectively on hold, including joint ventures and partnerships that could unlock the benefits of a larger global network.
Despite industry consolidation, van der Werff is confident the SAS brand will remain strong. He sees the airline’s Scandinavian hubs, particularly Copenhagen, as a natural engine for growth amid capacity constraints elsewhere in the Air France-KLM network. “There will be real, real growth potential,” he said, predicting that travellers will “see more of SAS in the future than what you’re seeing today.”
The airline is also exploring the practical applications of artificial intelligence across operations. Van der Werff said SAS spent much of last year identifying “five big bets” for AI, with a focus on improving customer experience and operational efficiency. Handling disruptions during harsh Nordic winters is a key priority. “Occasionally we get hit by real snowstorms,” he said, describing days with “100 cancellations a day” and aircraft, crew, and passengers scattered across the network. AI, he noted, could rebuild schedules faster and more accurately than human teams alone.
Van der Werff stressed that the aviation industry is moving beyond experimentation with AI toward tangible applications. While fully autonomous passenger aircraft remain a distant prospect, he highlighted smaller improvements such as optimising onboard supplies, reducing fuel use, and automating administrative tasks.
Disruption management, he said, is the most urgent area for AI implementation. “Tens of thousands, hundreds of thousands of passengers” may need rerouting during large-scale cancellations, and faster decision-making could reduce hotel stays, reposition aircraft and crews, and limit the ripple effects of delays. “How do you put that puzzle back together more quickly, more efficiently?” van der Werff asked.
Reflecting on the broader industry, he noted that uncertainty is constant, from health crises and financial shocks to geopolitical disruptions and fluctuating demand. “Something will always happen,” he said, citing events such as SARS, the financial crisis, and COVID-19.
Van der Werff called for faster decision-making in Europe to maintain competitiveness. “Europe needs to move faster,” he said, urging reduced bureaucracy and a clearer strategic vision to support innovation. Despite challenges, he remains optimistic about consolidation and technological advances, while highlighting the potential for Europe to embrace entrepreneurship and risk-taking once more.
Business
Azerbaijan’s SOFAZ fund gains from rising gold prices amid global market uncertainty
Azerbaijan’s State Oil Fund (SOFAZ) is seeing strong gains from its gold holdings, benefiting from the ongoing rise in global gold prices and generating substantial revenue for the country. The fund’s strategy reflects a wider trend among sovereign investors, who are increasing gold allocations to shield assets from global instability.
SOFAZ, the country’s sovereign wealth fund, was established to manage revenues from oil and gas exports and support long-term economic stability. The fund also plays a key role in financing the state budget and strategic national projects. As of January 1, 2026, gold accounted for 38.2 percent of SOFAZ’s investment portfolio, up from the previous year.
“Gold holdings are managed within the Fund’s approved investment framework, taking into account target allocations and allowable deviation bands,” SOFAZ said in a statement to Euronews. The fund uses gold as a hedge against external shocks, inflation, and broader market stress, aiming to protect capital and reduce exposure to volatility.
Gold prices recently reached record levels, surpassing $5,500 (€4,660) per ounce before falling sharply following the announcement of Kevin Warsh as the next chair of the US Federal Reserve. By Wednesday, prices rebounded to $5,000 (€4,230) per ounce. SOFAZ noted that its decisions on gold investments are guided by the fund’s overall risk-return strategy rather than short-term price movements.
“Gold plays a stabilising role within the Fund’s overall portfolio, and increasing gold holdings reduces sensitivity to adverse market developments, supporting a more balanced strategic asset allocation,” the fund said. Expanding its gold reserves is intended to safeguard Azerbaijan’s strategic financial assets and strengthen resilience amid global economic uncertainty.
SOFAZ began adding gold to its portfolio in 2012, gradually increasing allocations over time. In 2025, the fund purchased 53.4 tonnes of gold, raising total reserves to 200 tonnes. Over the past five years, SOFAZ generated $22.7 billion (€18.95 billion) in investment returns, including the benefits of gold price appreciation and exchange-rate effects.
The fund attributes its ability to navigate market downturns and recoveries to a diversified and resilient portfolio. The equity sub-portfolio, covering both public and private equities, has been a major driver of growth. Since the diversification strategy was launched in 2012, the equity portfolio has increased more than fourfold, delivering a 305 percent return and nearly $10 billion (€8.35 billion) in investment gains.
By combining oil revenues with a diversified investment approach and growing gold reserves, SOFAZ continues to strengthen Azerbaijan’s financial stability, preparing the country for both domestic and global economic challenges.
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