Health
No Proven Link Between Paracetamol Use in Pregnancy and Autism or ADHD, Major Review Finds
A new comprehensive review has found no reliable evidence that taking paracetamol during pregnancy increases the risk of autism or attention-deficit/hyperactivity disorder (ADHD) in children. The findings, published in The BMJ on Monday, counter recent claims that have reignited global debate over the safety of the widely used painkiller.
The review, conducted by researchers from leading universities and institutions in the United Kingdom, Australia, and Spain, analysed existing scientific studies after renewed public concern following remarks by former US President Donald Trump in September. During a campaign event, Trump urged pregnant women to “fight like hell” to avoid paracetamol, claiming it was linked to autism — a statement that drew swift backlash from medical experts.
The researchers reviewed nine previous systematic studies that examined a possible connection between paracetamol use in pregnancy and later diagnoses of autism or ADHD in children. While all nine suggested an association, the team found that most of them were based on weak or flawed evidence.
According to the review, many of the earlier studies failed to adjust for key health and lifestyle factors such as genetics, parental mental health, or environmental influences — variables that could affect a child’s development. Seven of the nine reviews also warned readers to interpret their findings cautiously due to the risk of bias and confounding factors.
“Our aim was to review all the existing research to understand the quality of the evidence and help healthcare professionals communicate accurate information to expectant mothers,” said Professor Shakila Thangaratinam, a women’s health expert at the University of Liverpool and one of the study’s authors. She told Euronews Health that the overall confidence in existing evidence was rated “low to critically low,” meaning it cannot be used to establish a causal link between paracetamol and neurodevelopmental disorders.
The review noted that when genetic and environmental influences were taken into account, any association between paracetamol use and the risk of autism or ADHD either disappeared or dropped sharply.
Paracetamol, known as acetaminophen in the United States and sold under brand names such as Tylenol, is one of the few pain and fever medications considered safe for use during pregnancy. Despite this, Trump’s comments led the US Food and Drug Administration (FDA) to recommend that manufacturers include warnings about potential neurological risks on paracetamol packaging.
The authors of the BMJ review urged more high-quality studies that examine how dosage, timing, and duration of paracetamol exposure during pregnancy might influence foetal development. They also warned against drawing conclusions or changing medical guidance based on unverified claims.
Professor Thangaratinam emphasised that decisions about medication during pregnancy should be grounded in strong evidence. “There is a sex and gender gap in science, and studies like this highlight the need for prioritising and investing in research focused on women’s health — particularly during pregnancy,” she said.
The review reinforces existing advice from global health agencies that paracetamol remains a safe and effective option for managing pain and fever in pregnancy when used as directed.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
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