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No Proven Link Between Paracetamol Use in Pregnancy and Autism or ADHD, Major Review Finds

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A new comprehensive review has found no reliable evidence that taking paracetamol during pregnancy increases the risk of autism or attention-deficit/hyperactivity disorder (ADHD) in children. The findings, published in The BMJ on Monday, counter recent claims that have reignited global debate over the safety of the widely used painkiller.

The review, conducted by researchers from leading universities and institutions in the United Kingdom, Australia, and Spain, analysed existing scientific studies after renewed public concern following remarks by former US President Donald Trump in September. During a campaign event, Trump urged pregnant women to “fight like hell” to avoid paracetamol, claiming it was linked to autism — a statement that drew swift backlash from medical experts.

The researchers reviewed nine previous systematic studies that examined a possible connection between paracetamol use in pregnancy and later diagnoses of autism or ADHD in children. While all nine suggested an association, the team found that most of them were based on weak or flawed evidence.

According to the review, many of the earlier studies failed to adjust for key health and lifestyle factors such as genetics, parental mental health, or environmental influences — variables that could affect a child’s development. Seven of the nine reviews also warned readers to interpret their findings cautiously due to the risk of bias and confounding factors.

“Our aim was to review all the existing research to understand the quality of the evidence and help healthcare professionals communicate accurate information to expectant mothers,” said Professor Shakila Thangaratinam, a women’s health expert at the University of Liverpool and one of the study’s authors. She told Euronews Health that the overall confidence in existing evidence was rated “low to critically low,” meaning it cannot be used to establish a causal link between paracetamol and neurodevelopmental disorders.

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The review noted that when genetic and environmental influences were taken into account, any association between paracetamol use and the risk of autism or ADHD either disappeared or dropped sharply.

Paracetamol, known as acetaminophen in the United States and sold under brand names such as Tylenol, is one of the few pain and fever medications considered safe for use during pregnancy. Despite this, Trump’s comments led the US Food and Drug Administration (FDA) to recommend that manufacturers include warnings about potential neurological risks on paracetamol packaging.

The authors of the BMJ review urged more high-quality studies that examine how dosage, timing, and duration of paracetamol exposure during pregnancy might influence foetal development. They also warned against drawing conclusions or changing medical guidance based on unverified claims.

Professor Thangaratinam emphasised that decisions about medication during pregnancy should be grounded in strong evidence. “There is a sex and gender gap in science, and studies like this highlight the need for prioritising and investing in research focused on women’s health — particularly during pregnancy,” she said.

The review reinforces existing advice from global health agencies that paracetamol remains a safe and effective option for managing pain and fever in pregnancy when used as directed.

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Switching from Gas to Electric Stoves May Help Reduce Asthma Symptoms, Study Finds

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Replacing a natural gas stove with an electric induction model may significantly improve asthma symptoms by reducing indoor air pollution, according to researchers at Case Western Reserve University in the United States.

The study found that switching from gas to electric cooking reduced indoor nitrogen dioxide levels by 70 per cent. The decline in pollution was linked to improvements in asthma symptoms among people with poorly controlled asthma.

Natural gas stoves release nitrogen dioxide and other nitrogen oxides when they burn fuel. These pollutants can accumulate indoors and may worsen breathing problems or trigger asthma attacks.

Researchers said the improvements seen after replacing gas stoves were comparable to, and in some cases greater than, those reported in clinical trials of commonly used asthma medicines.

Participants reported fewer breathing difficulties, fewer restrictions on daily activities and less need for rescue inhalers after the change. Emergency room visits and hospitalisations related to asthma also fell by 70 per cent among the participants, while missed days from work or school dropped by about 80 per cent.

The researchers chose electric induction stoves because they heat and cool quickly and are generally easier to clean than traditional electric coil models.

Ashwini Sehgal, a co-author of the study, said the findings suggested that reducing exposure to indoor pollution could play an important role in asthma management.

However, the researchers stressed that changing a stove is not a cure for asthma and may not benefit every patient. People with asthma should continue taking prescribed medication and working with their doctors to manage the condition.

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They should also try to reduce exposure to other common triggers, including cigarette smoke, dust mites, pollen and viral respiratory infections.

The cost of replacing a gas stove with an electric model could also prevent some households from making the switch. Researchers said the expense may be particularly difficult for low-income communities.

They suggested that governments or health insurers could consider financial support for households with patients suffering from poorly controlled asthma. The potential cost of replacing stoves could be offset in some cases by reductions in emergency treatment and hospital admissions.

The study involved 85 people with poorly controlled asthma. The research project was initially awarded three years of funding through the US Environmental Protection Agency’s Community Change Grants Program in December 2024.

However, the Trump administration ended the project before the planned completion date, leaving researchers unable to enrol additional participants after May 2025.

The findings add to growing concerns about indoor air quality and the health effects of gas cooking. Researchers said further work would be needed to determine how widely the results apply, but reducing indoor pollution could offer another way to support people managing asthma alongside standard medical treatment.

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France Records 5,764 Excess Deaths During Deadliest Heatwave Since 2003

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At least 5,764 excess deaths were recorded in France during last month’s record-breaking heatwave, making it the country’s deadliest heat event since 2003, according to new figures from the national public health agency.

Between June 17 and July 2, 21,674 people died in France, compared with an estimated 15,910 deaths expected under normal conditions, Santé publique France said in a bulletin published Wednesday.

The agency described the figure as the highest excess all-cause mortality recorded during a heatwave since 2003. That year’s extreme heat event caused nearly 15,000 deaths across France.

The latest heatwave was notable for its timing, intensity and duration. It struck early in the summer, when schools and workplaces were still operating normally, and exposed almost the entire French population to extreme temperatures.

For the first time, the public health agency recorded excess all-cause mortality across every age group from 15 years old and above. The agency said the pattern demonstrated the exceptional intensity and prolonged nature of the heat exposure.

People aged 75 and over accounted for around two-thirds of the provisional death toll, with at least 3,719 excess deaths recorded in that age group. However, deaths also increased among younger adults, making the event different from many previous heatwaves, when the impact was concentrated mainly among the elderly.

Mortality rose in hospitals, private homes and nursing homes. Almost half of the excess deaths occurred in hospitals, according to the preliminary data.

Santé publique France stressed that the excess deaths cannot yet be directly attributed to heat in every individual case. However, the scale and distribution of the increase point to the wider health impact of the extreme temperatures.

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The agency said the findings showed the need for governments and health authorities to introduce prevention and response measures before temperatures reach crisis levels.

“These impacts highlight the importance of implementing management and prevention measures to reduce the impact of heat on the population without waiting for health impacts to become apparent,” the agency said.

The French figures came as other Western European countries reported thousands of additional deaths during a heatwave in early July. Preliminary estimates suggested more than 4,000 people died across the region during that period.

The World Health Organization’s European office called on governments at the end of June to treat extreme heat as a major health crisis and strengthen the ability of health systems to respond.

Public health officials have warned that longer and more intense heatwaves are placing growing pressure on hospitals, care facilities and emergency services, increasing the need for early warnings and stronger protection measures.

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Up to Five Cups of Coffee a Day May Be Safe for Most Adults, Review Finds

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Drinking up to five cups of coffee a day may be safe for most adults and could be associated with a lower risk of several health problems, according to a major review by the American Heart Association.

The review found that consuming up to 400 milligrams of caffeine a day, roughly equivalent to five cups of caffeinated coffee, does not generally increase cardiovascular risk for most adults. Moderate consumption, particularly between two and four cups daily, was also linked to the lowest risk of death in the research examined.

“The equivalent of up to five cups of caffeinated coffee per day without added sugars or fillers is safe and does not increase cardiovascular risk,” said Gregory M. Marcus, a co-author of the paper and professor of medicine at the University of California, San Francisco.

The analysis found that moderate coffee consumption may be associated with better heart health and a lower risk of conditions including heart failure, heart disease and stroke. Some individuals also appeared to have a lower risk of high blood pressure and type 2 diabetes.

Coffee is the main source of caffeine for many adults, but daily intake can also come from tea, chocolate, fizzy drinks and some over-the-counter and prescription medicines. The researchers said less is known about the effects of caffeine from these sources, particularly at high levels.

Energy drinks were highlighted as an area requiring further study because large amounts of caffeine and other ingredients may pose cardiovascular risks.

Caffeine is processed by the liver and usually reaches its highest concentration in the blood within about an hour of consumption. The way people respond to it varies widely, however, depending on genetics, metabolism, age and previous caffeine intake.

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Regular coffee drinkers may develop some tolerance, while others can experience strong effects from relatively small amounts.

“Although research suggests that caffeine consumption may be associated with certain cardiovascular benefits for some people, it’s important to remember that there is no ‘one-size-fits-all’ strategy for safe caffeine consumption,” Marcus said.

He added that an amount that is reasonable for one person could cause side effects such as heart palpitations, anxiety or sleep disruption in another.

The researchers also warned that the way coffee is prepared can affect its overall health impact. Large amounts of added sugar, flavoured syrups and high-calorie dairy products can significantly increase calorie intake and may reduce the potential benefits associated with coffee itself.

The findings suggest that moderate, unsweetened coffee consumption can fit into a healthy lifestyle for many adults, but individual tolerance remains an important factor when deciding how much caffeine to consume.

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