Health
Doctors Warn Against Reliability of At-Home Gut Microbiome Tests
Medical experts are cautioning consumers about the growing popularity of at-home gut microbiome tests, saying the products are largely unregulated, often unreliable, and offer little practical medical insight beyond personal curiosity.
The tests, marketed by private companies for €90 to €460 or more, claim to analyse the trillions of bacteria living in a person’s intestines and provide personalised health insights. But gastroenterologists say the science behind these promises is still too limited to make meaningful recommendations.
“There’s a world in your gut that we still don’t know a lot about,” said Dr. Mark Benson, a gastroenterologist at the University of Wisconsin-Madison. “While there’s growing evidence that changes in the gut microbiome are associated with diseases like diabetes, liver disease, and obesity, we don’t yet know if those changes are a cause or a consequence.”
The gut microbiome — a complex ecosystem of bacteria that aids digestion, immune function, and even mental health — varies widely between individuals, and even within the same person over time. “Most of the variability between people, we don’t understand,” said Dr. Eamonn Quigley, head of gastroenterology and hepatology at Houston Methodist Hospital.
Most consumer microbiome tests require a stool sample, which is analysed by a private lab. Customers receive a report comparing their bacterial mix to what the company defines as an “ideal” microbiome. But experts note that no official medical standards exist for such comparisons. Unlike clinical stool tests ordered by doctors to diagnose infections or inflammation, these direct-to-consumer products are not federally regulated and vary widely in quality.
“When patients bring in these reports, there’s often little we can do with them,” said Dr. Sean Spencer, a physician-scientist at Stanford University. “Beyond antibiotics and diet, we don’t have reliable tools to change the microbiome.”
Some companies also blur the line between testing and sales. Nearly half of microbiome testing firms also sell supplements they recommend based on test results, according to Science Policy Forum. For example, wellness brand Thorne includes supplement suggestions with its reports. While its chief scientific officer Nathan Price denies any conflict of interest, critics warn that such practices can mislead consumers into unnecessary spending.
Doctors stress that people don’t need expensive tests to improve gut health. “Eat more plant-based fibre and protein, get good sleep, and exercise,” Benson advised. “Those habits have proven benefits — the tests don’t.”
Researchers remain hopeful that microbiome science will one day lead to targeted treatments for digestive and metabolic disorders. But for now, Quigley said, “We’re still in the early stages. Most people are simply wasting their money.”
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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