Health
Study Links Eating Habits to Effectiveness of Popular Weight Loss Drugs
Doctors may need to consider their patients’ eating behaviours before prescribing blockbuster weight loss drugs, new research suggests.
A Japanese study has found that people who eat in response to emotions may not see the same benefits from widely used medications such as Ozempic, Wegovy, and Mounjaro as those who overeat when food looks or smells appealing. These drugs, known as glucagon-like peptide-1 (GLP-1) receptor agonists, mimic a hormone that reduces appetite and are increasingly prescribed for both diabetes and weight loss.
The year-long study, published in Frontiers in Clinical Diabetes and Healthcare, tracked 92 patients with diabetes who were taking GLP-1 drugs. Researchers from Gifu University and Kyoto University collected data on participants’ diets, blood markers, body composition, and weight changes. They also assessed patients’ relationships with food, focusing on three main eating patterns: eating in response to negative emotions, eating when food appeared appetising, and restricting diet for weight loss purposes.
Diverging Results Based on Eating Style
Most participants lost significant weight and showed improvements in cholesterol levels during the first year of treatment. However, outcomes varied depending on eating habits.
Those who tended to overeat because food looked appealing experienced the most consistent weight loss and improved blood sugar control over 12 months. In contrast, participants who relied on food to manage emotions were less likely to sustain benefits.
At the three-month mark, many patients showed greater control over their eating and were less likely to eat for emotional reasons or because of the appearance of food. But by the 12-month point, emotional and restrictive eating habits had re-emerged, suggesting that psychological factors may undermine long-term progress.
“Individuals with prominent emotional eating tendencies may require additional behavioural or psychological support,” said Dr Takehiro Kato, clinical lecturer at Gifu University and one of the study’s authors. “One possible explanation is that emotional eating is more strongly influenced by psychological factors which may not be directly addressed by GLP-1 receptor agonist therapy.”
Calls for More Research
While the findings highlight a potential link between eating behaviour and treatment outcomes, the researchers stressed that larger studies are needed before changes to clinical practice can be made.
“While our study suggests a potential association between external eating behaviour and treatment response to GLP-1 receptor agonists, these findings remain preliminary,” said Dr Daisuke Yabe, professor at Kyoto University and co-author of the study. “Further evidence is necessary before they can be implemented in clinical practice.”
The results underline the growing recognition that medication alone may not be sufficient for lasting weight loss, especially for patients who struggle with emotional eating. Experts say combining drug treatment with dietary guidance and psychological support may be the most effective path forward.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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