Health
Drug-Resistant ‘Nightmare Bacteria’ Infections Surge Across US, CDC Warns
Drug-resistant infections linked to so-called “nightmare bacteria” are rising sharply in the United States, with rates climbing nearly 70 percent between 2019 and 2023, according to new data from the Centers for Disease Control and Prevention (CDC).
The surge is being driven by bacteria carrying the NDM gene, which renders many treatments ineffective. Once considered rare and primarily associated with patients who had received medical care abroad, these infections are now spreading more widely across the US. CDC researchers published their findings Monday in the Annals of Internal Medicine.
The study found that cases of carbapenem-resistant bacterial infections — resistant even to last-resort antibiotics — rose from fewer than 2 per 100,000 people in 2019 to more than 3 per 100,000 in 2023, a 69 percent increase. But infections specifically caused by NDM-producing bacteria surged more than fivefold over the same period, from 0.25 to about 1.35 cases per 100,000.
“The rise of NDMs in the US is a grave danger and very worrisome,” said David Weiss, an infectious disease researcher at Emory University. He warned that many people may be carrying the bacteria unknowingly, raising the risk of community spread.
The threat extends to common illnesses long considered easy to treat. “Infections like urinary tract infections could become chronic problems,” said Dr. Maroya Walters, one of the study’s authors.
Currently, only two antibiotics are effective against NDM-linked infections, and both are costly treatments that must be administered intravenously.
Experts say the rise is partly linked to widespread antibiotic use during the COVID-19 pandemic. “We know that there was a huge surge in antibiotic use during the pandemic, so this likely is reflected in increasing drug resistance,” said Dr. Jason Burnham, a researcher at Washington University.
Antimicrobial resistance develops when bacteria and fungi evolve to withstand drugs designed to kill them. Misuse of antibiotics — such as taking unnecessary prescriptions or not completing a prescribed course — has been a key driver, making pathogens harder to treat over time.
CDC researchers analyzed data from 29 states that routinely test and report cases of carbapenem-resistant infections. In 2023, they documented 4,341 such cases, including 1,831 involving NDM. The report did not specify how many patients died.
However, the CDC stressed that the findings likely underestimate the true extent of the problem. Major states including California, Florida, New York, and Texas were not part of the dataset, and many hospitals lack the resources to conduct the genetic testing needed to detect resistance.
A separate CDC report published in June had already flagged a sharp rise in NDM cases in New York City between 2019 and 2024, reinforcing concerns about a growing national health threat.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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